Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"transthyretin"”.
-
The role of transthyretin in Alzheimer disease pathology
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Transthyretin expression in cultured and native human retinal pigment epithelium
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Transthyretin Amyloidosis: Proteolytic cleavage accelerates G53A TTR misfolding and aggregation
… CD and FT-IR profiles, suggesting similar transthyretin morphology during the early and late stages of amyloidosis. Aggregation kinetics was accomplished by monitoring the optical density of G53A TTR in the presence and absence of trypsin and by comparing the ThT fluorescence signal …
-
Liver transplantation for transthyretin amyloidosis: experience of a single center in Italy
… is the only definitive treatment for transthyretin amyloidosis, with an excellent 5-year survival in endemic countries where the Met30 mutation is predominant. We report our experience of liver transplantation for transthyretin amyloidosis. We reviewed the clinical records of 17 …
-
Transthyretin-, Aß 1-40- und Aß 1-42- und Tau-Protein-Konzentrationen im Liquor cerebrospinalis bei demenziellen Erkrankungen
… wurden die Liquor cerebrospinalis Spiegel von Transthyretin, Tau-Protein sowie der beta-Amyloidpeptide 1-42 und1-40 bei 106 Patienten mit unterschiedlichen Demenzerkrankungen wie Alzheimer-Demenz, Creutzfeldt-Jakob-Krankheit, Lewy-Körperchen-Demenz, frontotemporale Demenz und …
-
Determinants and Monitoring of Response to Disease-Modifying Therapy for Transthyretin Amyloidosis Cardiomyopathy: The ATTR-CM Therapy Study
Transthyretin amyloidosis cardiomyopathy (ATTR-CM) is a heart muscle disease characterized by the accumulation of misfolded transthyretin proteins as amyloid plaques in the myocardial interstitium. In 2020, tafamidis, a medication inhibiting the misfolding of transthyretin, received Health Canada's …
-
Characterization of AG10, a potent stabilizer of transthyretin, and its application in enhancing in vivo half-life of therapeutic peptides
… of Immunoglobulin (Ig) light chains or transthyretin (TTR) in the cardiac interstitium and conducting system, represent an important and often underdiagnosed cause of heart failure. Two types of TTR-associated amyloid cardiomyopathies are clinically important. The Val122Ile (V122I) …
-
A transthyretin-related gene and a neuroligin-like gene prevent 6-hydroxydopamine-induced dopaminergic neurodegeneration in <i>C. elegans</i>
… the neuroligin-like gene <i>glit-1</i> and the transthyretin-related gene <i>ttr-33</i>. Neuroligins are transmembrane proteins involved in the development and function of synapses. We provide evidence that <i>glit-1</i> and the previously identified tetraspanin <i>tsp-17</i> are associated with …
-
Structure of T6SS components and assessment of potential Gram-ve drug targets
… to 1.92 Å and displays a fold similar to that of transthyretin; a protein that binds the hormone thyroxine. Despite the sequence identity between the two proteins being low, SmLip can be considered a new member of the transthyretin-like protein family. A role is suggested for loop 1 being involved …
-
Synthesis of novel thyroid hormone analogues
… acids were also prepared in good yield. Transthyretin (TTR) was isolated from human plasma by column chromatography and the prepared phenoxybenzoic acids were tested for binding to the isolated protein. The most potent compounds were found to be 3-phenoxybenzoic acid (26), 2-(2,4- …
-
STRUCTURE-BASED APPROACHES TO DATA-DRIVEN PROTEIN FOLDING, AGGREGATION, AND SELF-ASSEMBLY
… ensemble of amyloid-b42 the aggregation of transthyretin peptides, and the self-assembly of ferritin complexes. Complementary to these studies, conventional molecular dynamics simulations are used to research the effect of electric fields on the dynamics of amyloid b42 fibrils, revealing the …
-
Solid state nuclear magnetic resonance methodology and applications to structure determination of peptides, proteins and amyloid fibrils
… conformation of peptide fragment 105-115 of transthyretin in an amyloid fibril is investigated.
-
Directed differentiation of endodermal cells from mouse embryonic stem cells
… a production of hepatocyte markers (AFP-2 and transthyretin) but there was insufficient data to assess for convincing production of hepatocytes. In summary, one of the protocols produced cells that displayed characteristics of definitive endoderm and they may serve as pancreatic endocrine …
-
On The Development, Characterization, And Use Of Protein Fluorescence And Infrared Spectroscopic Probes
… mutation in a short segment of the protein transthyretin (i.e., 110-115) induces formation of amyloid fibrils consisting of both β- and α-sheets, where the latter is a proposed structure in proteins, but has never been observed previously.
-
RACE-Seq identifies the Argonaute-2 cleavage products of RNA interference-based oligonucleotides
… activity of a Dicer substrate siRNA targeting transthyretin revealed that this molecule by-passed Dicer processing but still induced RNAi activity. In examining RACE-Seq peak profiles, an on-target mechanism of action (MOA) for up to four active siRNA derived from siRNA19 is proposed. The …
-
Bronchoalveoläre Lavage bei Kindern mit malignen Erkrankungen, Immunsuppression, Fieber und Lungeninfiltraten
… vermehrt, der Anteil an Ig-bindendem Faktor, Transthyretin und Cystatin S schien jedoch vermindert zu sein. Im Bereich der kleinen sauren Proteine behinderte der relativ hohe Anteil an Immunglobulinketten die Separation und Identifikation einzelner Proteine. Diese Daten zeigen, dass es bei …
-
Plant-parasitic nematodes: from genomics to functional analysis of parasitism genes
… nematode EST libraries. Some members of the transthyretin-like gene family of R. similis were characterized. All stages except developing embryos express the analyzed genes, and expression is localized to the ventral nerve cord and tissues surrounding the vulva. Predicted secondary structure …
-
Amyloid fibril structure of peptides and proteins by magic angle spinning NMR spectroscopy and dynamic nuclear polarization
… residue segment from the disease-related protein transthyretin (TTR); and P2- microglobulin (32m), a 99-residue protein associated with dialysis-related amyloidosis. The TTR(105-115) case exemplifies our efforts to characterize the hierarchy of structures present in the fibril form, including the …
-
Rekombinante Hepatitis B Viren-Vektoren als Werkzeuge für Molekularbiologie und Therapie : Optimierung eines Systems
… das Ersetzen des preS2/S-Promoters durch den Transthyretin-Promoter konnte eine Infektion von lebenden PHH zu einem früheren Zeitpunkt nachgewiesen werden, ohne die Leberspezifität des Promotors zu verlieren. Mit Renilla-Luziferase als Transgen gelang es, den Nachweis einer Infektion zu …
-
Investigating biomarkers in clinical samples that are predictive of response in multiple myeloma
… Vitamin D binding Precursor (VDB), Transthyretin (TYR), Zinc alpha 2-glycoprotein (ZAG), Serum Amyloid A protein (SAA), Beta-2-microglobulin (B2M), had higher abundance level with fold changes of 1.31 (p=0.00044), 1.32 (p=0.0077), 1.48 (p= 0.0000022), 3.01 (p=0.006) and 1.96 …
Page 1 of 2