Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"transpresentation"”.
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
… IL-15 is delivered by a novel mechanism termed transpresentation: IL-15 is presented by a cell expressing IL-15Ralpha to the CD8 T cell which responds via IL-2Rbeta/gamma<sub>c</sub>. The identity of what cells transpresent IL-15 to support the survival and homeostatic proliferation of memory …
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
… IL-15 is delivered by a novel mechanism termed transpresentation: IL-15 is presented by a cell expressing IL-15Ralpha to the CD8 T cell which responds via IL-2Rbeta/gamma<sub>c</sub>. The identity of what cells transpresent IL-15 to support the survival and homeostatic proliferation of memory …
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Determining The Mechanisms Generating Soluble Il-15 Complexes
… discovered a shared mechanism of enhanced IL-15 transpresentation common to all types of lymphopenia, while only forms of lymphopenia associated with inflammation display increases in sIL-15 complexes. The optimal production of sIL-15 complexes in response to total-body irradiation (TBI) required …
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Tethered Il-15 to Augment The Therapeutic Potential of T Cells Expressing Chimeric Antigen Receptor: Maintaining Memory Potential, Persistence, and Antitumor Activity
… T cells mimicked the physiologic mechanism of transpresentation to sustain costimulation via phosphorylation of signal transducer and activator of transcription (pSTAT5). In contrast to conventional CD19-specific CAR T cells, mIL15-CAR T cells persisted in mice independent of the presence of …