Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"transposon silencing"”.
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The Role of Maelstrom in the Drosophila piRNA Pathway
… to genomic instability. In Drosophila ovaries, silencing of these elements is tightly regulated through the establishment of heterochromatin which prevents TE mobilisation. Piwi guided by piRNAs to nascent TE transcripts, it recruits factors necessary for creating transcriptionally repressive …
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Dynamics of DNA methylation and genomic imprinting in arabidopsis
… in diverse cellular processes, ranging from transposon silencing to genomic imprinting. In plants, DNA methylation is both mitotically and meiotically heritable, and changes in DNA methylation can be generationally stable and have long-lasting consequences. This thesis aims to improve …
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Characterization of the roles of Xrn1p in small-RNA-mediated gene-silencing pathways
… interference (RNAi) is a small-RNA-mediated gene-silencing pathway that is involved in viral defense, transposon silencing, heterochromatin formation, and post-transcriptional gene silencing. Most RNAi pathways are initiated by long, dsRNA which is processed by Dicer into small interfering RNAs …
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The Role of Hiwi in Stem Cell Maintenance and Sarcomagenesis
… in the germline are thought to maintain transposon silencing, and thus ensure genomic stability. A detailed mechanism by with Piwis suppress transposon migration in the germline remains an area of active investigation, but is thought to occur via DNA methylation of transposon regions. In …
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Discovery and profiling of animal small RNAs using deep sequencing
… including post-transcriptional gene regulation, transposon silencing, DNA methylation, chromatin modifications and chromosome segregation. The ability of the new deep sequencing technologies to sequence millions of short RNAs in a few hours have made them the method of choice for simultaneous …
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DNA Damage responses in plant stem cells
… damage caused by endogenous processes such as transposon movement. Plant stem cell populations in particular must be protected from genotoxicity, as they are the origin of all organs, together with the germline. In accordance with this premise, plant stem cells were found to be hypersensitive …
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Regulatory Mechanism of the RNAi Pathway
… interference (RNAi) is post-transcriptional gene silencing initiated by Dicer, a RNase III that processes double-stranded RNA (dsRNA) precursors into small interfering RNA (siRNA). In Drosophila, Dicer2 and R2D2 coordinately recruit duplex siRNA to the effector RNA-induced silencing complex …
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Mechanisms of piRNA biogenesis and co-transcriptional silencing of transposable elements in Drosophila
… consists of mobile, repetitive elements called transposons. Since their uncontrolled mobilisation is a potentially harmful event, several molecular mechanisms have evolved to counteract transposon activation and thus safeguard genome integrity. Among these is the piRNA pathway, a gonad-specific …
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Dynamic changes of TDP-43 in testicular and epididymal sperm
… gene transcription, mRNA splicing and stability, transposon silencing, and micro RNA biogenesis. TDP-43 is associated with many neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Our lab previously demonstrated that sperm from …
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Transcriptional regulation of the piRNA pathway in animal ovarian germ cells
… somatic follicle cells which suppresses gypsy transposon mobilization from soma to germline. Overall, the results of my thesis reveal the conserved transcription factor Ovo as the master regulator of the female germline piRNA pathway in Drosophila ovaries and provide evidence that this function …