Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 100 for “"transposable elements"”.
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Transposable Elements in Neural Progenitor Cells
… gene expression and is therefore indispensable. Transposable elements comprise about 50% of the genome and co-exist as symbionts regulated by epigenetic mechanisms - a highly defined machinery that controls gene expression and is mandatory for a proper development and maintenance of an organism. …
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Understanding Host Tolerance to Transposable Elements
Transposable elements (TE) are mobile genetic parasites, whose unregulated activity in germline causes DNA damage, and results in sterility. Host genomes can avoid these fitness costs of TEs either by regulating TE proliferation, or by altering gametogenesis to tolerate TE-induced DNA damage. …
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Mosquito Transposable Elements and piwi Genes
… with disease-resistant transgenic mosquitoes. Transposable elements (TEs) are an important component in this new strategy due to their ability to integrate exogenous DNA into chromosomes. They could potentially be useful tools in assisting the spread of disease-resistant genes in mosquito …
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Transposable elements and the regulatory logic of hematopoietic differentiation
… factors, chromatin modifiers and cis-regulatory elements is central to establish cellular identity and function. Understanding this regulatory logic is critical for deriving select cell types in vitro for translational applications. The human hematopoietic system has long been a model system and …
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Transposable Elements and the Evolution of Virus Resistance in Drosophila melanogaster
… genes. In this thesis I will explore the role of transposable elements in the evolution of virus resistance. We discover a Doc retrotransposon insertion in the Drosophila gene Veneno (Ven; CG9684), a gain of function mutation which confers resistance to Drosophila A Virus (DAV). We show that the …
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Transposable elements: What have you done for me lately? A genomics based investigation into the potential functional roles of transposable elements using the model organism Caenorhabditis elegans
… DNA sequences present as disperse repetitive elements called transposons. Transposons have the unique ability to move to new chromosomal locations. Problems of uncontrolled movement of transposons can result in mutations, rearrangement, and even broken chromosomes. Often termed "selfish …
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The impact of Terminal Inverted Repeat (TIR) transposable elements on plant genomes
<p>As major components in eukaryotic genomes, Transposable Elements (TEs) have been studied for decades. In the 1950s to 1990s, the predominant opinions considered TEs as “junk DNA” and “selfish elements”. However, subsequent studies showed that TEs are important players in genome dynamics. TEs are …
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DD34E DNA Transposable Elements of Mosquitoes: Whole-Genome Survey, Evolution, and Transposition
Transposable elements (TEs) are mobile genetic elements capable of replicating and spreading within, and in some cases, between genomes. I describe a whole-genome analysis of DD34E TEs, which belong to the IS630-Tc1-mariner superfamily of DNA transposable elements, in the African malaria mosquito, …
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New insights into Transposable Elements from high quality genome sequences across diverse animals
… have opened the possibility of identifying new transposable element (TE) families by their polymorphic character in different haplotypes, in contrast to previous methods based on repetitiveness, homology and structural features. In this work, divided in four sections, I show how we can leverage …
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Mechanisms of piRNA biogenesis and co-transcriptional silencing of transposable elements in Drosophila
… genomes consists of mobile, repetitive elements called transposons. Since their uncontrolled mobilisation is a potentially harmful event, several molecular mechanisms have evolved to counteract transposon activation and thus safeguard genome integrity. Among these is the piRNA pathway, a …
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Using signal processing, evolutionary computation, and machine learning to identify transposable elements in genomes
About half of the human genome consists of transposable elements (TE's), sequences that have many copies of themselves distributed throughout the genome. All genomes, from bacterial to human, contain TE's. TE's affect genome function by either creating proteins directly or affecting genome …
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HUMAN GENOME VARIATIONS AND EVOLUTION WITH A FOCUS ON THE ANALYSIS OF TRANSPOSABLE ELEMENTS
… using a novel approach. All human-specific AluYb elements from the reference genome were extracted, aligned with one another to construct clusters of similar copies and each cluster was analyzed to generate the evolutionary relationship between the members of the cluster. The approach resulted in …
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Investigation of the Conservation of Biological Function in Transposable Elements using a Multiple Alignment Strategy
… non-coding genome was found to be occupied by transposable elements (TEs), DNA with transposition capability which can either benefit or disrupt gene functions depending on their destination. TEs are considered foreign and viral-like intruders which can affect genome integrity and therefore …
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Population genetics of P transposable elements and their host species, with emphasis on Drosophila willistoni and Drosophila sturtevanti
… (subgenus Sophophora). The transmission of P elements among species, their spread within species and the strength of selective constraints, as well as the level at which they are imposed on these elements, were investigated using DNA sequence data. Particular emphasis was placed on the …
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Somaclonal Variation in Inbreds and Testcrosses of Maize (Zea Mays L.) and the Possible Involvement of Transposable Elements
… the activation of endogenous but quiescent transposable elements following passage of cells through tissue culture.
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Using a novel large-scale epigenetic analysis method to uncover the cis-regulatory potential of individual transposable elements
Transposable elements (TEs) are DNA sequences with the potential to move or replicate and insert themselves at new genomic locations. Over evolutionary time, many sequences derived from TEs have accumulated and account for 50% of the human genome. These mobile elements were initially considered …
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Language like behavior in protein secondary structure and analysis of mitochondrial genomes and transposable elements in Antarctic notothenioid fishes
… the dependence of length of secondary structure elements against the number of secondary structures in a protein domain in 60 proteomes and observed a negative correlation between the number of secondary structures and their average lengths in all proteomes, showing that protein secondary …
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Regulation of Mu transposition via communication between the transposase and Mu-encoded accessory protein
Transposable elements comprise a significant portion of both prokaryotic and eukaryotic genomes. These mobile segments of DNA have helped to shape the course of evolution by generating genetic mutations and contributing to genomic rearrangements. Transposable elements often target transposition to …
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Identification and annotation of recombinant repeats in mammals indicates they are experimental products for creating novel transposable element families.
… of mammalian genomes are made up of repetitive elements, primarily transposable elements. Transposable elements' activities not only drive genome evolution, they contribute to the creation of novel recombinant repeats. Recombinant repeats have largely remained uncharacterized due to their …
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Development of broadly applicable transgenic tools for the transposon mutagenesis of the red flour beetle, Tribolium castaneum
… discovery of non-species-specific, broad-range transposable elements and the establishment of a universal 3xP3 promoter revolutionized insect transgenesis. It overcame the limitations of the germ-line transformation to be restricted to the model organism Drosophila melanogaster. In combination …
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