Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 661 for “"transporters"”.
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Identification Of Heavy Metal Transporters
Increased release of heavy metals of geogenic and anthropogenic origin has led to generation of multiple polluted sites in the USA and across the world that are waiting for efficient clean-up technologies. Phytoremediation uses plants to mitigate these types of environmental problems, and provides …
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Mechanistic studies of ABC transporters
ATP-binding cassette (ABC) transporters are a superfamily of primary membrane transporters that are abundant yet highly diverse in structures and functions. These proteins power the active transport of a large variety of substrates across biological membranes, by harnessing the energy of ATP …
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Structures and Mechanisms of Lysosomal Transporters
Lysosomal membrane transporters are indispensable for maintaining lysosomal homeostasis and proper function. Indeed, mutations in these key proteins can lead to debilitating disorders known as lysosomal storage diseases. Cystinosin and Sialin are two such transporters. Both proteins utilize the low …
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Structure and function of glutamate transporters
… glutamate transport by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal transporter. Broadly, using computational methods to probe EAAT homology models born from the archaeal structures, we introduce/describe …
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Structure and function of glutamate transporters
… glutamate transport by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal transporter. Broadly, using computational methods to probe EAAT homology models born from the archaeal structures, we introduce/describe …
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Amino Acid Transporters in Arabidopsis Thaliana
Two novel amino acid transporters, LHT1 and ART1, were identified from the Arabidopsis EST cDNA library by complementation. LHT1 is a lysine and histidine transporter, and ART1 is an arginine and aromatic amino acid transporter. ART1 seemed to possess transport activity for IAA and other aromatic …
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Screening for purine transporters in S. aureus
Staphylococcus aureus is an important human pathogen and crucial part of its pathogenesis depends on its ability to acquire purines to cause disease. In this study, I screened a library of individual mutants under purine import-dependent conditions by inhibiting the purine biosynthesis using the …
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Analysis of Zinc Transporters in C. elegans
… is mediated by numerous proteins including zinc transporters, zinc-responsive transcription factors and zinc-binding proteins. Of these proteins, zinc transporters, composed of CDF and ZIP families, play a major role and are implicated in a variety of human diseases. However, the mechanisms by …
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Structure-function studies of SLC15 peptide transporters
… and PepT2 (SLC15A2; low capacity, high affinity) transporters which are involved in the co-transport of protons and di- and tri- peptides and drugs similar in structure (peptidomimetics). PepT1, and to a lesser extent PepT2, have therefore gained attention due to their role in determining the …
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Structural and Functional Studies of Nucleoside Transporters
… unrelated protein families of nucleoside transporters, the concentrative nucleoside transporters and the equilibrative nucleoside transporters. We aimed to elucidate their transport mechanisms using X-ray crystallography and biochemical assays. We solved multiple crystal structures of CNT …
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Regulation of glucose transporters in sheep placenta
Transplacental glucose transport is vital to fetal growth. Although the presence of glucose transporter-1 (GLUT1) and GLUT3 has been demonstrated in mammalian placenta, the factors regulating these genes remain unclear. Therefore, the overall aim of these studies was to clone ovine GLUT1 (oGLUT1) …
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Functional characterization of nitrate transporters in maize.
… by nitrate permeable transport proteins. Nitrate transporters have been extensively studied in the model plant, Arabidopsis thaliana. Nitrate transporters belong to three protein families: NPF (Nitrate Transporter 1/Peptide Transporter), NRT2 (Nitrate Transporter 2) and CLC (Chloride Channel) …
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Structural and Functional Study of Multidrug Membrane Transporters
<p>Multidrug membrane transporters (efflux pumps) in both prokaryotes and eukaryotes are responsible for ineffective treatment of a wide variety of diseases, including infections and cancer, underscoring the importance of better understanding of their structures and functions for design of …
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Identification and analysis of Arabidopsis thiamine pyrophosphate transporters
… and investigate mitochondrial thiamine transporters in Arabidopsis. The approaches used to achieve the aims of this project include phylogenetic analysis, mutant analysis, polymerase chain reaction techniques and gene construct techniques. AtTpc1 and AtTpc2 have a limited effect on plant …
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Mechanism and energetics of membrane transporters and channels
… specialized transport proteins called membrane transporters and channels that catalyze exchange of materials across the cell membrane. Membrane trans- porters couple the active transport of their specific substrates against their electrochemical gradient. On the other hand, membrane channels …
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IN SILICO CHARACTERIZATION OF THE RECOGNITION MECHANISM OF RIBOFLAVIN TRANSPORTERS RFVT1, RFVT2, AND RFVT3, AND ORGANIC CATION TRANSPORTERS OCTN1 AND OCTN2
Questa tesi esplora le caratteristiche strutturali e funzionali dei trasportatori della famiglia SLC (solute carrier), identificati come promettenti bersagli per scopi farmacologici. Questi trasportatori transmembrana sono elementi fondamentali per l'omeostasi cellulare, e alterazioni nella loro …
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Structure-function studies of human SLC36 amino acid transporters
… known as the human Proton coupled Amino acid Transporters (hPATs).This is due to hPATs 1 and 2 having been functionally characterized as proton coupled transporters that bring about a 1:1 symport of H+ and an amino acid across the membrane (with optimum uptake at an extracellular pH of 5.5). …
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Chemical selectivity principles of translocation catalysis by membrane transporters
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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