Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"transporter inhibitor"”.
-
Developing Label-free Imaging Techniques to Study Biological and Energy Conversion Processes
… in the HeLa cell line in the presence of glucose transporter inhibitor and drug dosage for 14 hours.
-
Investigating Therapeutic Strategies to Target Metabolic Vulnerabilities of Nsclc Tumors With Mutant Keap1 Gene
… expression status drives sensitivity to glucose transporter inhibitor as tested in cell lines and mouse xenograft studies. The Pro-cell death function of KEAP1-NRF2-SLC7A11 signaling in the context of glucose starvation revealed in this work is unexpected and unique, representing a significant …
-
Fused Heterocycles as Spinster Homolog 2 Inhibitors and Regio- and Stereoselective Copper-Catalyzed Borylation-Protodeboronation of 1,3-Diynes: Access to (Z)-1,3-Enynes
… S1P can be transported extracellularly by S1P transporters spinster homolog 2 (Spns2) or major facilitator domain containing 2B (mfsd2b). In the extracellular space, S1P can bind to S1P-specific G-protein coupled receptors (S1PR), which initiate many signaling pathways. A critical role of …
-
Improving Potency and Oral Bioavailability of Spinster Homolog 2 (Spns2) Inhibitor: A Structure-Activity Relationship Study
… focus of medicinal chemistry campaigns is the transporter protein spinster homolog 2 (Spns2). This protein is responsible for the transport of S1P from intracellular space to extracellular space to interact with its receptors and induce the immune response. Recently, our group has developed …