Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 965 for “"transporter"”.
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Serotonin transporter import
… neurotransmission and members of this family of transporters are a popular target in the treatment of depression, addiction, obsessive compulsive disorder, and generalized anxiety disorder including the serotonin transporter and the dopamine transporter. These transporters have been the targets …
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Pharmacological Chaperones of the Dopamine Transporter: A Strategy for Increasing Function of Wild Type and Mutant Transporter
The dopamine transporter (DAT) is a membrane protein that is essential for regulating signaling and intracellular stores of the neurotransmitter dopamine. An array of pathological conditions have been linked to mutations in the dopamine transporter gene, including ADHD, bipolar disorder, autism, …
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The role of Thyroid hormone Transporters Monocarboxylate Transporter 10 (MCT10) and Monocarboxylate Transporter 8 (MCT8) in extravillous trophoblasts.
… fetal and placental development. Monocarboxylate transporters 8 and 10 (MCT8, MCT10) are effective plasma membrane TH transporters expressed in the human placenta from 6 weeks of gestation. Both have been localized to human villous trophoblasts and extravillous trophoblasts (EVTs). Aims: Using …
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Role of glucose transporter 1 during pregnancy
… profiling has shown that Hif2α regulates Glucose transporter1 (GLUT1). GLUT1 is the dominant glucose transporter in the uterus and has been linked to human infertility. Based on these points, we chose to investigate the role of GLUT1 in pregnancy by deleting GLUT1 from the uterus using two …
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The Molecular Mechanism of the Escherichia Coli vitamin B12 Transporter BtuCD-F: Real-time Observation of the Transporter in Motion
The Escherichia coli vitamin B12 transporter BtuCD-F is a type II importer belonging to the ABC transporter superfamily. Available data suggest both exporters and type I importers in the ABC superfamily employ similar transport mechanism in which the transmembrane (TMDs) are open to cytoplasm in …
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Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
… Saq vitamin prodrugs targeting influx nutrient transporters and circumvent the P-gp mediated efflux as well as CYP3A4 mediated metabolism thus improving the absorption and bioavailability of Saq. First, two vitamin transport systems including sodium-dependent multivitamin transporter (SMVT) and …
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Flavonoids and Related Compounds as Nucleoside Transporter Inhibitors
<p>Mammalian nucleoside transporters can be classified into two main categories, namely, equilibrative nucleoside transporters (ENTs) and concentrative nucleoside transporters (CNTs). ENTs are ubiquitous, and mediate sodium-independent bi-directional facilitated diffusion nucleoside transport …
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Molecular Characterization of Dopamine Transporter Phosphorylation and Regulation
<p>The dopamine transporter (DAT) is a presynaptic membrane phosphoprotein that terminates dopaminergic synaptic transmission by clearing dopamine (DA) back into presynaptic neuron by a reuptake process. DAT is also a molecular target for psychostimulants such as cocaine, amphetamine (AMPH) and …
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STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER
<p>Glutamate transporters have a homotrimeric subunit structure with a large central water-filled cavity that extends partially into the plane of the lipid bilayer (Yernool et al., 2004). In addition to uptake of glutamate, the transporters also mediate a chloride conductance that is gated by Na+ …
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STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER
<p>Glutamate transporters have a homotrimeric subunit structure with a large central water-filled cavity that extends partially into the plane of the lipid bilayer (Yernool et al., 2004). In addition to uptake of glutamate, the transporters also mediate a chloride conductance that is gated by Na+ …
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Characterization of a human renal organic anion transporter
… step of this process involves the organic anion transporter 1 (OAT1), recently cloned from the rat, mouse and flounder, which mediates the uptake of an organic anion in exchange for an intracellular dicarboxylate. This study represents the first reported cloning of a human OAT1 homologue, hROAT1, …
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Characterization of an Evolving Serotonin Transporter Computational Model
… and function of a central target, the serotonin transporter (SERT). Established SERT inhibitors (SSRIs) were docked to an in silico SERT model to identify likely binding pocket amino acid residues. When mutated singly, no one of five implicated residues was critical for high affinity in vitro …
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Investigating the function of the multidrug transporter ABCG2
ABCG2 is a polyspecific membrane transporter of the ATP-binding cassette (ABC) superfamily, which is responsible for the efflux of a wide array of structurally unrelated molecules from mammalian cells. Physiologically, the protein is thought to serve a protective role; ABCG2 is expressed in certain …
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Development of A Gene Therapy for Creatine Transporter Deficiency
… depletion of creatine in the brain. Creatine transporter deficiency is one of the three Cerebral creatine deficiency syndromes caused by loss of function mutations in the X-linked SLC6A8 gene. In the absence of creatine transporter cells are unable to uptake creatine, resulting in a depletion …
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Neurochemische und autoradiographische Untersuchungen von Serotonin-Transporter-Knockout-Mäusen
Um die Auswirkungen der allelischen Expressionsvariabilität des 5-HTT auf das Gehirn zu untersuchen, wurde eine transgene 5-HTT-Knockout-Maus entwickelt, die als Grundlage der Untersuchungen der vorliegenden Arbeit diente. Vor allem aufgrund der Assoziation des kurzen Allels des …
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Modulation of the Serotonin Reuptake Transporter in RAW264.7 Macrophages
… and animmune modulator. The serotonin reuptake transporter (SERT) clears the extracellular space of 5-HT, which decreases the effects of 5-HT on target cells. This study demonstrated that the RAW264.7 macrophage cell line expresses SERT function, measured by assays of 3H-5HT uptake. The 5-HT …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
… with proteins that are energy-dependent efflux transporters driven by ATP hydrolysis, making MDR1 a member of the ATP binding cassette (ABC) super family. Because, MDR1 transports substrates that are often toxic xenobiotics, MDR1 is thought to fulfill a cellular detoxification function. As such …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
… with proteins that are energy-dependent efflux transporters driven by ATP hydrolysis, making MDR1 a member of the ATP binding cassette (ABC) super family. Because, MDR1 transports substrates that are often toxic xenobiotics, MDR1 is thought to fulfill a cellular detoxification function. As such …
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Therapeutic targeting of the ATP7A copper transporter in cancer
… distribution, and export. The high-affinity Cu transporter 1 (CTR1) mediates cellular Cu uptake, while the P1B-type ATPase ATP7A facilitates Cu transport from the cytosol into the lumen of vesicles or the trans-Golgi network (TGN), where it metalates cuproenzymes such as the lysyl oxidase (LOX) …
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