Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"transport proteins"”.
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Investigating nuclear transport proteins as secreted cancer biomarkers
… analysis identified members of the nuclear transport protein family as significantly upregulated in cervical cancer biopsies compared to normal cervical epithelial tissues. These results were validated at both mRNA and protein levels, and similar upregulation observed in oesophageal cancer. …
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Molecular and Functional Analyses of Transport Proteins for Organic Anions
… it is of particular interest to study active transport processes for charged substances across this tissue, especially because many drugs are substrates for these transport proteins. Transporters in the CP are similar to those in the kidney. Therefore, I performed comparative experiments with …
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Computational study of the structure and function of membrane transport proteins
Transport of the nutrients across the cell membrane is regulated by membrane transport proteins which selectively and efficiently transports materials across the membrane. In the present work I focus on the family of membrane transporters the so called sugar porters in both their mammalian and …
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Investigating the role of nuclear transport proteins secreted by cancer cells
… in our laboratory have shown that the nuclear transport protein Importin 1 (Kpnb1) is upregulated in several types of cancer and is crucial to cancer cell survival. Recent findings from our laboratory showed that Kpnb1, amongst other proteins is secreted into the extracellular space by …
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Functional characterisation of ScIRT1 and ScIREG2 transport proteins in the nickel hyperaccumulator, Senecio coronatus
… ScIREG2 , putative homologues of the Arabidopsis transporters, AtIRT1 and AtIREG2 which are capable of transporting Ni, showed much higher expression in the hyperaccumulating populations compared to the non-hyperaccumulating populations, suggesting a potential role in Ni hyperaccumulation. It was …
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Towards functional assignment of Plasmodium membrane transport proteins: an experimental genetics study on four diverse proteins
Membrane transport proteins (MTPs) transfer nutrients, metabolic products and inorganic ions across membranes. Many MTPs are essential for Plasmodium blood infection and gain importance as candidate drug targets in malaria therapy, whereas the physiological functions of many MTPs still remain …
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Towards functional assignment of Plasmodium membrane transport proteins: an experimental genetics study on four diverse proteins
Membrane transport proteins (MTPs) transfer nutrients, metabolic products and inorganic ions across membranes. Many MTPs are essential for Plasmodium blood infection and gain importance as candidate drug targets in malaria therapy, whereas the physiological functions of many MTPs still remain …
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Expression and regulation of the nuclear transport proteins, Crm1 and Kpnß1, in cervical cancer and transformed cells
Includes abstract. Includes bibliographical references (leaves 204-223).
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Characterisation of putative metal transport proteins in the nickel hyperaccumulator Senecio coronatus: investigating candidate genes for nickel tolerance and accumulation
… serpentine soils in South Africa. The nickel-transporting abilities of three proteins (ScMATE, ScVIT and ScCOP), previously shown to be constitutively over-expressed in shoot tissues of hyperaccumulating populations of S. coronatus, were investigated in order to determine if they play a role …
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Demonstration of peptide and free amino acid absorption by sheep forestomach epithelium using parabiotic chambers and identification of H⁺/peptide and free amino acid transport proteins in sheep omasal epithelium and b<sup>o,+</sup> amino acid transport proteins in pig jejunal epithelium by expression of mRNA in Xenopus laevis oocytes
… complementary to the cloned human kidney b⁰‘⁺ transporter. Oocytes were injected with RNA isolated from omasal epithelial tissue of sheep (average BW = 67.5 kg) to identify potential peptide and amino acid transport proteins. Injection of specific RNA fractions induced greater rates of …
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Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
… increases the affinity of prodrug to the peptide transporter protein. Entrapment efficiency values of L-valine-L-valine-ACV and L-valine-D-valine-ACV were optimal with PLGA 75:25 and PLGA 65:35 polymers, respectively. In vitro release of prodrugs from nanoparticles exhibited a biphasic release …
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Comparison of expression pattern and localization of iron transport proteins in rat liver, brain and spleen during acute phase response:invivo and invitro studies
… und unterschiedliche Lokalisation der Eisentransportproteine zu vergleichen, Transferrin-Rezeptor (TfR) -1 und 2, divalenten Metallions transpoter-1 (DMT-1) und Ferroportin-1 (FPN-1) in Ratten Leber, Gehirn und Milz während der Akutphase-Antwort auf experimentelle Gewebeschädigung. …
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Effects of dietary calcium, phytoestrogen rich diets and estrogen on intestinal calcium transport proteins, egg and eggshell quality in maturing layer hens / Ali Asghar Saki.
Investigates whether estrogen modulates the proteins associated with calcium transport (eg calcium binding protein, calbindin D28k) in the intestinal tissue during sexual maturation of laying hens. Studies the temporal and spatial expression of estrogen receptors (ER) and calcium binding protein in …
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The Role of the SCD1 Protein in Targeting PIN2 Protein in Arabidopsis Thaliana
Auxin transport polarity is established and maintained by the asymmetrical localization of auxin transport proteins in the plasma membrane. The <italic>SCD1<italic> (stomata cytokinesis defective) gene encodes a protein containing a DENN domain, which is predicted to function as a RAB-GEF, which …
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Development of pseudosymmetry analysis to identify key residues in transport protein mechanisms
Transport proteins, despite making up approximately 10% of the human genome, are understudied. Multiple computational tools exist to analyse them, but no tool exists to predict which residues are likely to be involved in substrate binding or in the mechanism of the transporter. In this thesis, I …
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The role of mitochondrial transporters in human physiology and adverse drug effects
… mechanisms are largely unknown. Mitochondrial transport proteins form a significant class of potential off-targets that remain largely unexplored. The main aim of this thesis is to evaluate the role of human mitochondrial transporters in adverse drug effects, to overcome the technical …
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The role of auxin transport in the control of shoot branching
… outgrowth, by changing properties of the auxin transport network, increasing the competition between buds. This occurs by modulating access to the polar auxin transport stream (PATS) in the main stem. The PATS provides directional, long distance transport of auxin down the stem, involving basal …
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Structure-function studies of human SLC36 amino acid transporters
… Carrier family 36 (SLC36) of integral membrane transport proteins has four members which are also known as the human Proton coupled Amino acid Transporters (hPATs).This is due to hPATs 1 and 2 having been functionally characterized as proton coupled transporters that bring about a 1:1 symport of …
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The role of Iron Regulated 2 and Iron Regulated Transporter 1 in nickel hyperaccumulation traits in Senecio coronatus
… (Asteraceae) identified a number of putative transport proteins that are constitutively upregulated in the hyperaccumulator plants. This MSc project focused on two of these, iron regulated 2 (ScIREG2) and iron regulated transporter 1 (ScIRT1), and aimed to validate the RNA-Seq derived …
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