Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 963 for “"transplantation"”.
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Immunoisolation Approaches for Islet Transplantation
The widespread use of islet transplantation as a treatment for type 1 diabetes is limited in part by the necessity for long term immunosuppression. The principle of immunoisolation is to create a physical barrier surrounding the islets to prevent immune destruction after implantation, therefore …
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Donor heart preservation for heart transplantation
Heart transplantation has enjoyed a spectacular success over the past 25 years. Prior to 1980 less than 350 operations were carried out with an overall one year survival of less than 60%. In 1995 more than 3,000 transplants were performed with a one year survival of 83%. However, growth and …
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Strategies for improving islet transplantation outcome
Allogeneic islet transplantation offers the possibility to treat selected patients with brittle Type 1 Diabetes Mellitus (T1DM). Limited availability of islets is a major obstacle to the more widespread use of islet transplantation as a therapy for the majority of patients with T1DM. This is …
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Immune reconstitution post bone marrow transplantation
… bone marrow and peripheral blood stem cell transplantation and to compare this with the recovery following autologous grafts. to document the cell surface expression of CD95 in an attempt to comment on the role played by FAS mediated apoptosis in the post transplant immune deficiency.
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Targeted Priority Mechanisms in Organ Transplantation
The persistent shortage of transplantable organs, compounded by high rates of organ underutilization, necessitates innovative allocation mechanisms. This dissertation develops and analyzes targeted priority mechanisms, voluntary incentive-based programs designed to enhance access for disadvantaged …
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Lebensqualität und Gelenkfunktion nach Knorpel-Knochen-Transplantation
… klinischen Therapieeffektes der Knorpel-Knochen Transplantation. Mit der Hypothese, dass durchschnittlich 7 Jahre postoperativ eine signifikante Verbesserung von (1) Lebensqualität, (2) Gelenkfunktion und (3) Knorpelstruktur vorliegt (p<0,05), wurde der Einfluss von Alter, BMI, Defektgröße sowie …
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The transplantation of bone : an experimental study
In recent years greet advances have been made in the understanding of the nature of the reaction of a host to transplants of tissue of homogenous origin. In general, such transplants fail because of the development of an immune response by the host against the transplant. The success of bone …
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Bone marrow transplantation in infancy and childhood
During a bone marrow transplant there is a major risk of infection either due to the specific disease or as a result of the required preconditioning. Severely neutropenic patients benefit from receiving prophylactic antimicrobial agents within a protected environment and the thesis opens with a …
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Germinal centre autoantibody responses following heart transplantation
… of humoral autoimmunity following organ transplantation is increasingly recognised, but of uncertain significance. I address the key question whether autoimmunity contributes independently to chronic graft rejection. In a MHC class II-mismatched murine model, I show that antinuclear …
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Targeting Mitochondrial ROS Production in Kidney Transplantation
… exist to ameliorate the effects of IRI in organ transplantation (or other IRI-related pathologies), partly due to an incomplete understanding of the underlying pathophysiology. Recently, a specific mechanism of mitochondrial reactive oxygen species (ROS) production, thought to initiate many of …
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TRANSPLANTATION IMMUNOGENETICS OF THE CANINE TRANSMISSIBLE VENEREAL TUMOR.
TRANSPLANTATION IMMUNOGENETICS OF THE CANINE TRANSMISSIBLE VENEREAL TUMOR.
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Xenogeneic transplantation of immortalized bovine mammary epithelial cells
… cell line as a starting material for xenogeneic transplantation into the mammary glands of immunocompetent recipients. PSG-5 cells (a clonal derivative of the MAC-T cell line engineered to express ovine IGF-I ) were transplanted into the cleared mammary fat pads of recipient mice. Following …
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Enhancing Metabolism of Donor Hearts for Cardiac Transplantation
… a major cost to the health care system. Heart transplantation remains the most effective treatment for end-stage heart failure. However, transplantation can only be offered to a small fraction of patients with this disease due to the inadequate supply of available organs. A major factor …
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Tendon Transplantation in the Treatment of Paralytic Equinus
<p>[Abstract Not Included, Preface Follows]</p> <p>With the continued high incidence of paralytic poliomyelitis the crippling after effects of this disease will be seen for many years to come even if the number of new cases gradually decrease as effective immunization techniques are developed. …
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Molecular imaging of gene transduction in cardiac transplantation
… target pathological processes following cardiac transplantation faces many challenges including the potential effects of the virus on the host as well as the need to establish the presence of the gene in the target organ. In the first set ofexperiments (Chapter 2), concerns over the effects of …
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