Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"transmission blocking"”.
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Adenovirus Vectors as Potent Adjuvants in Vaccine Development
… properties of Ad in vaccines to prevent transmission of malaria by Plasmodium falciparum. When combined with vaccines preventing infection, transmission-blocking vaccines (TBVs) could limit the spread of malaria. Our study explores how novel, Ad5-based TBVs enhance the humoral immune …
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Analysing the role of Protein Disulphide Isomerase in Plasmodium and targeting function to block transmission
… has been identified as a putative target for transmission blocking interventions in Plasmodium spp. Located on the surface of the male gamete and ookinete, previous studies have demonstrated that this protein is essential for successful malaria transmission. PDIs are chiefly implicated in …
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The role of midgut serine proteases in Aedes aegypti vector competence
… control strategies through approaches such as transmission blocking vaccines.
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Transmission Competence of B. burgdorferi Infected Ixodes Ticks and Development of an OspC-Based Lyme Disease Vaccine
… Studies have shown OspA to be an effective transmission-blocking vaccine. Therefore it is also important to investigate the transmission-blocking properties of the OspCCt vaccine observed in the ticks recovered from infected and vaccinated mice. <strong>Objective.</strong> Our first goal is …
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Understanding Developmental Decision Making in Malaria Parasites using Single-Cell Transcriptomics
… replication within red blood cells, whereas transmission to new hosts relies on fertilisation and replication in the mosquito. Both disease development and transmission are therefore underpinned by the parasite’s ability to serially differentiate into morphologically distinct forms. This …
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Investigating the role of the Apicoplast in Plasmodium falciparum Gametocyte Stages
… to reveal novel targets for development of transmission-blocking agents. Furthermore, increasing drug resistance of the parasites to current antimalarials, including slowed clearance rates to artemisinin, requires the discovery of innovative drugs against asexual intraerythrocytic stages …
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Molecular candidates for Blocking the Transmission of Vector-Borne diseases
… strategies and solutions have emerged. Transmission blocking vaccines are one among many solutions available to manage the control of VBDs. These require identification of both vector and pathogen molecules that play important roles in the transmission, dissemination and establishment of …
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Unravelling the molecular mechanisms of Leishmania mexicana adhesion in the sand fly vector
… critical for infection maintenance and efficient transmission and occurs through its flagellum via a complex adhesion plaque from which filaments in the modified flagellum extend towards the cell body and likely connect to the flagellum attachment zone (FAZ), a cytoskeletal structure important for …
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Characterisation of Plasmodium parasite sexual commitment and development
… sexual forms, is therefore essential for malaria transmission, and an attractive target for transmission blocking interventions. Despite its importance, we know little about sex-specific gene expression or how the decision to become male or female is made. Efforts to understand gametocytogenesis …
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Synthesis, pharmacological and physicochemical profiling of antimalarial and antischistosomal N-aryl 3-trifluoromethyl pyrido [1,2-α] benzimidazoles
… the potential for malaria chemoprevention and transmission blocking.
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Antimalarial imidazopyridazines and aminopyrazines: synthesis, physicochemical optimization and structure-activity relationships
… which need redress. In addition, prevention of transmission and relapse with better safety profiles than current medicines are some of the important features that should be a prioritized characteristic of new medicines. Most importantly, these new regimens should be able to offer chemoprotection …