Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"transmembrane transport"”.
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Differences in Gene Expression Responses to Heat Shock Between Warm- and Cool-Adapted Isolates of Batrachochytrium dendrobatidis
… expression of genes associated with cellular and transmembrane transport activities. Cool-adapted isolates also downregulated the expression of genes relating to peptidase production, a known virulence factor of Bd. This variation in gene expression broadly supports the hypothesis that Bd’s …
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The design of synthetic transmembrane carriers for anions
… of novel receptors found to facilitate the transmembrane transport of anions in synthetic vesicle systems. A series of structurally simple thioureas were found to function as efficient Cl-/NO3- and Cl-/HCO3- antiporters while the corresponding ureas were inactive. Of these receptors, a …
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Development of Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spns2 for the Treatment of Multiple Sclerosis
… the cell. This process is facilitated by the transmembrane transport protein Spinster homolog 2 (Spns2) in most vertebrates. Studies in murine species have demonstrated that the protein plays a key role in directing immune cell chemotaxis and the progression of autoimmune diseases. …
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A novel and rational approach towards designing aluminium chelators
… investigated the influence of chelators on the transmembrane transport of Al, identifying 1,2-diethylhydroxypyridin-4-one as a ligand showing greatest potential for chelating Al in the clinical situation. In conclusion, these studies have explored semi-empirical MO Hamiltonians and an in-vitro …
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A Study of Cellular Amino Acid Homeostasis Identifies Novel Targets, Inhibitors and Combination Therapies in Cancer
… homeostasis is maintained by a combination of transmembrane transport processes, metabolic pathways, protein synthesis and turnover, and signalling systems to furnish cells, tissues, organs, and organisms with optimal levels of these nutrients. Understanding how these elements support amino …
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A Study of Cellular Amino Acid Homeostasis Identifies Novel Targets, Inhibitors and Combination Therapies in Cancer
… homeostasis is maintained by a combination of transmembrane transport processes, metabolic pathways, protein synthesis and turnover, and signalling systems to furnish cells, tissues, organs, and organisms with optimal levels of these nutrients. Understanding how these elements support amino …
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Investigating the genetic basis of cisplatin-induced ototoxicity in adult South African patients
… variants in six genes which are involved in drug transport and processing, potential modifiers in the genes nuclear factor, erythroid 2-like 2 (NFE2L2) and solute carrier family 22, member 2 (SLC22A2) were identified. SLC22A2 encodes a known transporter of cisplatin, and the variant rs316019 …
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Physics-informed Deep Learning and Differentiable Mechanistic Models for Multicomponent Transport Phenomena
… mechanistic models for multicomponent membrane transport; (2) the development and validation of physics-informed deep learning surrogate models for transmembrane transport phenomena. In the former, we relax many of the assumptions present in traditional models, while introducing more …
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Proteomic analysis of Pseudomonas putida F1 during growth on toluene-phenol mixtures
… of cellular membrane in favor of toluene transport and inhibited the transport of phenol into the cell. Once the cell consumed toluene, the membrane structure changed to be favorable to phenol transport across the cell membrane. The production of β-ketoadipate:succinyI CoA transferase …
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Identification of up-regulated genes of the hyphomycete, Beauveria bassiana, during infection of Leptinotarsa decemlineata
… peptidase, a/b-hydrolase enzyme), three probable transporters (ABC transporter, siderophore transporter, oligopeptide transporter), a presumed metabolic enzyme (pyruvate decarboxylase), a probable V-ATPase, two putative mucin-like proteins and a putative protein, which shares homology with an …
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Computational Modeling of Osmotically Assisted Membrane Separations with Multicomponent Solution-diffusion Theory
… modeling of the solute-coupling effects for transmembrane transport is integral to the development, and subsequent optimization, of OAMP unit operations. Theoretically, in binary mixtures, species separation is achieved due to the solution-diffusion mechanism, which results from the …
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Cytochrome P450 whole cell biohydroxylation of alkanes
… caused by a combination of alkane solubility and transmembrane transport. Although n-decane is less soluble in water than n-nonane, the ‘odd-even’ effect of alkanes resulted in high in vivo activity on n-decane. UNIF-LL predictions illustrated that BEHP reduces the amount of alkane in the aqueous …
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Investigation of biological macromolecules using atomic force microscope-based techniques
… These results support the working model for transmembrane transport proteins that provide alternate access of the binding site to either face of the membrane. Finally, high-resolution imaging was exploited to visualize the extracellular surface of Cx26 gap junction hemichannels (connexons). …
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Roles of Small Rnas and Paralogous Proteins In Bacillus Anthracis Virulence Gene Regulation
… amino acid metabolism, proteolysis, and transmembrane transport. <em>In silico</em> analysis revealed complementarity between XrrA and the 5’ UTR of seven mRNA transcripts whose expression is affected by the sRNA, suggesting base-pairing interactions. A translational fusion of one of …
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From Genes to Traits and Ecosystems: Evolutionary Ecology of <i>Sphagnum</i> (Peat Moss)
… secondary metabolism, stress response, and transmembrane transport. Together, these data suggest that selection favored changes to genes involved in response to environmental stress and provide candidate loci that might underlie adaptation to the harsh conditions of boreal peatlands.</p></p>
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Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies
… by mutations in critical ion channels and transporters, such as microcytic anemias, cystic fibrosis, and cardiovascular diseases. Deficiencies of these ion transporting proteins diminish ion flux in distinct sites and directions. Noting the many features that make small molecules …
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Nanopore technology for DNA sequencing
Made available in DSpace on 2010-08-20T17:58:37Z (GMT). No. of bitstreams: 3 Comer_Jeffrey.zip: 226477214 bytes, checksum: 58e732aa747f3bd4da0e576ddcc65779 (MD5) Comer_Jeffrey.pdf: 19129383 bytes, checksum: be143050e3104cb300d385ce2da0c51e (MD5) license.txt: 4062 bytes, checksum: …
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Functional Genome-wide Association Studies (fGWAS) and genomics landscape of signatures of polygenic adaptation in Botswana populations with HIV-1 C infection
… secretion, solute carrier (SLC)-mediated transmembrane transport, and neurodegenerative processes. Such terms have also been linked to various clinical phenotypes including HIV-1 infection, human cytomegalovirus (CMV), and cancers suggesting possible cross phenotype associations. For the …