Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"transmembrane signaling"”.
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Structural Basis of Bacterial Transmembrane Signaling
… have evolved membrane-bound receptors and signaling proteins to detect and respond to external signals, regulating essential processes such as nutrient acquisition, stress adaptation, and cell-to-cell communication. However, the molecular mechanisms of cross-membrane signaling remain …
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Transmembrane Signaling in Bacillus Subtilis Chemotaxis: Determination of the Packing Organization and Structural Changes of McpB in Response to Ligand
"In Chapter 5, we investigated the complementation and activity of a methylesterase phosphorylation point mutant, C-terminal truncated mutant, and a serine active site mutant in vivo to the attractant asparagine to determine the role CheB phosphorylation plays in regulation of receptor …
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Resolving Signal Transduction in Complex Biological Environments
… and G-protein coupled receptors (GPCRs), transmembrane signaling in enzyme-linked receptors have so far remained elusive due to the presence of only a single transmembrane helix in their structure for signal propagation. In this work, we explore the signal transduction in the epidermal …
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Molecular Investigations of Protein Assemblies Involved in Prokaryotic Virulence
… and the discovery of a potentially universal transmembrane signaling mechanism.
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Independence and interdependence: signal transduction of two chemosensory receptors important for the regulation of gliding motility in Myxococcus xanthus
… To examine whether DifA shares similar transmembrane signaling mechanism with typical transmembrane sensor proteins (MCPs and sensor kinases), we constructed a chimeric protein that is composed of the N-terminus of NarX (nitrate sensor kinase) and the C-terminus of DifA. This NarX-DifA …
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The methuselah family of g protein coupled receptors
… (GPCRs) are one of the largest class of transmembrane signaling proteins that regulate essential developmental and physiological processes in a cell. GPCR success is illustrated by their abundance across both invertebrate and vertebrate genomes. Phylogenetic analyses show that GPCR …
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Structure, Function and Dynamics of G-Protein coupled Receptors
… to elucidate the molecular mechanisms by which transmembrane signaling based physiological processes,i. e., the interactions of extracellular ligands with membrane-bound receptors, are regulated. In this work, synthetic transmembrane segments derived from the visual photoreceptor rhodopsin, the …
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Gpi-Anchored Proteins In Ciliated Protozoa: From Ca++ Signaling To Mitochondrial Extrusion
… discovered more than a hundred years ago, the signaling mechanisms underlying these effects are still unknown. To investigate transmembrane signaling events in response to i-antigen clustering we used Ichthyophthirius multifiliis, a parasitic ciliate, and Tetrahymena thermophila, a well-studied …
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Learning the ABC's of Ribose Transport Using Biophysical Methods
… it to the membrane spanning permease, RbsC. Transmembrane signaling connects RbsB arrival at RbsC with inward rotations of RbsA subdomains that stimulate ATP hydrolysis. This leads to ribose delivery to the permease translocation channel. Post-hydrolysis, outward rotation of RbsA subdomains …
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Identification of Previously Unknown Interactions Between G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
… and their role in regulating GPCR-mediated transmembrane signaling is not well understood. For example, receptor activity-modifying proteins (RAMPs), a family of single transmembrane proteins with only three members, are ubiquitously expressed and have been shown to interact with several …
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Modification of Lipid Microenvironments on Solid Support Structures for Use in Transmembrane Protein Assays
<p>Gamma-Secretase (γ-secretase) is a transmembrane protease of increasing interest, which has been shown to have significant connections to both cancer and Alzheimer’s disease. γ-secretase cleaves both Notch-1, a transmembrane signaling protein, and Amyloid precursor protein (APP), a transmembrane …
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Development of Novel Chemical Biology Tools for Probing Structure-Function Relationships in G Protein-Coupled Receptors
… receptors (GPCRs) constitute a large family of transmembrane receptors that transduce extracellular signals into intracellular biochemical responses. Understanding with chemical precision how GPCRs function in cellular membranes is an active area of biological research, but despite recent …
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Lipidické rafty a jejich role v transmembránové signalizaci zprostředkované receptory spřaženými s G proteiny
Membránové mikrodomény obohacené o cholesterol a sfingolipidy, neboli lipidické rafty a kaveoly, přispívají k mnoha buněčným procesům včetně homeostázy cholesterolu či laterální segregace membránových proteinů. Tato bakalářská práce se zabývá vlivem těchto membránových mikrodomén na …
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Regulation of Bovine Mammary Epithelial Cell Response by Autocrine IGF-I and by Collagen I
… how insulin-like growth factor-I (IGF-I) signaling in mammary epithelial cells may be modified or interrupted by modifications in the cellular environment may lead to 1) methods to increase the growth and proliferation of normal mammary epithelial cells for an increase in the amount of …