Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 894 for “"transmembrane"”.
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Artificial Transmembrane Signalling
… In this dissertation, an indirect artificial transmembrane signalling mechanism which operates by controlled translocation of a synthetic transducer across the lipid bilayer was investigated. The fundamental concept of the translocation mechanism is the switching of membrane-permeability of …
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Investigating transmembrane TNF and transmembrane p55TNFR mediated signaling in host immune function during Mycobacterium tuberculosis infection
The importance of TNF-TNFR signaling in immunity against M. tuberculosis has been established. The aims of this study were to characterize the functions of membrane-bound TNF (Tm-TNF) and soluble TNF (solTNF) and to investigate the role of membrane-bound p55TNFR signaling as well as the in vivo …
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A Transmembrane Precursor of Secretory Component
… not as soluble secretory forms, but as larger transmembrane forms that are core glycosylated and asymmetrically integrated into the dog pancreas microsomal vesicles with an 11-15 kilodalton domain remaining in the cytoplasm. We studied the biosynthesis and processing of human SC in a cell-free …
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Structural Basis of Bacterial Transmembrane Signaling
… molecular dynamics simulation data suggest that transmembrane signaling in McpZ involves both piston-type and scissoring movements. These findings contribute to a broader understanding of bacterial chemotaxis signaling. GacS is a central component of the GacS/GacA phosphorelay system, positioned …
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Junction Specificity and Transmembrane Linkages of Integrins
We have also isolated a monoclonal antibody, P4B2, which localizes to multiple adhesion junctions, namely, a subset of focal adhesions, the Z-disc of muscle, and neuromuscular junctions. Immunopurification of the antigen to this antibody from chicken brain tissue yielded a complex of three …
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The design of synthetic transmembrane carriers for anions
… of novel receptors found to facilitate the transmembrane transport of anions in synthetic vesicle systems. A series of structurally simple thioureas were found to function as efficient Cl-/NO3- and Cl-/HCO3- antiporters while the corresponding ureas were inactive. Of these receptors, a …
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Signaling of integrin lower leg and transmembrane domains
… clear how this signal is transmitted from the transmembrane domain through two long extracellular legs to the ligand-binding headpiece. In addition, integrin TM homomeric association was also observed. But the role of this interaction remains elusive. In this work, the platelet integrin, …
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Artificial Transmembrane Signalling and Cooperativity in H-Bonded Networks
… two areas, with a first project on artificial transmembrane signalling, and a second on cooperativity in hydrogen bonded networks. Cells rely on complex signal cascades where proteins are responsible for the transmission and amplification of chemical signals across membranes. While numerous …
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The Cystic Fibrosis Transmembrane Conductance Regulator: Regulation by HSP-90
<p>The hypothesis of this project is that a functionally relevant association exists between CFTR and Hsp90. In testing this hypothesis, (a) the association of CFTR and Hsp90 is confirmed via crosslinking and immunoprecipitation of CFTR from stably transfected HEK-293 cells, electrophoretic …
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EFFECT OF CRYOPROTECTANT EQUILIBRATION ON TRANSMEMBRANE POTENTIAL OF BOVINE OOCYTES
… osmotically induced volume perturbation on the transmembrane potential of bovine oocytes. The aim of this study was to evaluate and examine the difference in putative effects of non-permeating (PBS) and permeating (10% EG) solutions and to explore the association between osmotically induced …
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Biochemical Analysis of SNARE Protein Interactions – Role of Transmembrane Domain
SNARE (soluble NSF attachment protein receptor) Proteine umfassen verschiedene Familien von Proteinen, welche in Eukaryonten von der Hefe bis hin zum Menschen vorkommen. Sie sind für die Membranfusion bei zellulären Prozessen, wie Vesikeltransport, Neurotransmitterausschüttung oder …
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Identification and characterization of layilin, a talin-binding transmembrane protein
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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Polymer Supported Lipid Bilayer Membranes for the Integration of Transmembrane Proteins
… for the successful integration of functional transmembrane proteins (TMPs). As each cushion exhibits different physico-chemical properties, the resulting behaviour of the sLBMs and TMPs could be exactly adjusted to the specific requirements of biological samples. This is exemplarily shown by …
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NUCLEAR ENVELOPE TRANSMEMBRANE PROTEIN DISTRIBUTION AND TRANSPORT STUDIED BY SINGLE-MOLECULE MICROSCOPY
… nucleus and cytoplasm by forming a barrier. NE transmembrane proteins (NETs) embedded in either the outer nuclear membrane (ONM) or the inner nuclear membrane (INM) play crucial roles in both nuclear structure and functions, including: genome architecture, epigenetics, transcription, splicing, …
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Conformation of Transmembrane Segments of a Protein by a Coarse Grain Model
… by the cooperative response of different transmembrane segments of the protein. It is believed that the two subunits of the C-terminal dimer provide independent proton channel pathways through the membrane where the conformations of both monomers and dimer are key for selective proton …
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CHARACTERIZATION OF TRANSMEMBRANE PROTEIN 35 EXPRESSION: CONSIDERATIONS OF SEX AND OVARIAN HORMONES
<p>The recently discovered novel neuropeptide transmembrane protein 35 (TMEM35), is believed to modulate chemical signaling within the nervous system. Notably, the TMEM35 protein is detectable in humans, non-human primates and rodents, suggesting a conserved and critical function. Despite this, the …
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Machine learning applications for the topology prediction of transmembrane beta-barrel proteins
… on the topology prediction of beta-barrel transmembrane proteins. Transmembrane proteins adopt various conformations that are about the functions that they provide. The two most predominant classes are alpha-helix bundles and beta-barrel transmembrane proteins. Alpha-helix proteins are …
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The study of two transmembrane autophagy proteins and the autophagy receptor, p62
… several proteins at its core which include two transmembrane proteins, ATG9 and VMP1. While ATG9 and VMP1 has been discovered for about a decade and half, the trafficking and function of these proteins remain relatively unclear. My work in this thesis identifies and characterises a novel …
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