Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"translocate"”.
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Biochemical characterisation of the translocation of material through the protective antigen (PA) Pore
… antisense oligonucleotide (ASO) complex to translocate and mediate gene modulation was assayed in vitro. The components of this complex were found to be non-toxic individually and together (PA8 3, LFn-GAL4:ASO). This complex was found to be able to deliver ASOs and mediate cytosolic access …
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Characterization Of Streptolysin O As The Translocator For The Cytolysin-Mediated Translocation Process In Streptococcus Pyogenes
… <underline>O</underline>: SLO) to translocate the <italic><underline>S.</underline></italic> <italic><underline>p</underline>yogenes</italic> <underline>N</underline>AD<super>+</super>-glycohydrolase: SPN) effector into the cytosol of eukaryotic host cells. Although, the …
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Effects of combustion derived air pollution on vascular and fibrinolytic function in man
… nanoparticulates or soluble components of PM may translocate into the bloodstream, resulting in direct effects on the vascular endothelium and thrombotic pathways. I investigated the potential for inhaled radiolabelled nanoparticulates to translocate into the circulation in man. Using two unique …
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How Oomycete and Fungal Effectors Enter Host Cells and Promote Infection
… A large subset of effector proteins is able to translocate into host cells and target plant defense pathways. P. sojae Avr1b is able to suppress cell death triggered by BAX and hydrogen peroxide. The W-domain of Avr1b is responsible for this functionality, and is recognized by the Rps1b gene …
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Sex in southern african spirostreptida millipedes : mechanisms of sperm competition and cryptic female choice
… of sperm transfer. The emotes function to translocate ejaculates from the penes to the vulvae, where they are stored. A delay between insemination and fertilisation provides an arena for syn- and postcopulatory sexual competition. These operate at the gametic level via sperm competition and …
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Microtubule Motors Drive Nuclear Dynamics and Positioning in Developing Skeletal Muscle Cells
… elucidated. Here, we find that nuclei actively translocate through myotubes. As they translocate, they also rotate in three-dimensions. These movements require an intact microtubule cytoskeleton, which forms a dynamic bipolar network around the nuclei, and are driven by the microtubule motor …
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Nuclear Translocation of Met Via Internet Mechanism
… evidence demonstrating that most of RTKs can translocate into nucleus to regulate cellular processes in response to both ligand and stress stimulation. Oxidative stress is a common stress in cancer cells due to alteration of metabolism, and constitutive oxidative stress related to reactive …
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COMPARATIVE CELL BASED FUNCTIONAL ANALYSIS OF KEY WNT/BETA-CATENIN PATHWAY GENES AND GENE MUTATIONS
… allowing Beta-catenin protein to accumulate and translocate to the nucleus. In the nucleus, Beta-catenin activates transcription of its target genes by binding TCF/LEF transcription factors. Aberrant Wnt/Beta-catenin signaling activity leads to misregulation of proliferation and metabolic …
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REGULATORY MECHANISM OF DUSP16 IN CANCER RESISTANCE TO PLATINUM-BASED THERAPIES
… of the Bcl-2 protein family. Activated Bax translocate to mitochondria to trigger caspase 9/3 apoptosis. We showed that inhibition or knocking out of Bax in DUSP16-overexpression cells abrogated DUSP16-mediated chemoresistance. In conclusion, this study demonstrated that DUSP16 expression in …
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The role of a monomer/dimer equilibrium and the C-terminal tail in regulating translocation of sphingosine kinase 1 to the plasma membrane of breast cancer cells
Sphingosine kinase-1 (SK1) is able to translocate from the cytoplasm to the plasma membrane (PM) to catalyse the formation of sphingosine 1-phosphate (S1P) from sphingosine and adenosine triphosphate (ATP). It is known that both the expression and activity of SK1 is increased in many tumour types …
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Isolation and Use of the Aeromonas hydrophila Secretin ExeD for Nanopore Analysis
… could be made about the ability of ExeD to translocate small molecules and peptides. If ExeD could translocate larger peptides than α-hemolysin, nanopore analysis could be expanded to include these larger molecules. Nanopore research has previously been done using the ExeD homologues PulD …
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Characterization of nanopores with internal cavities for DNA manipulation using Langevin dynamics simulations
… both longer and shorter chains take longer to translocate. The length at which this occurs is named the critical length. This phenomenon arises as a balance between the driving electric force field and the entropic barrier that must be overcome in order for the polymer to exit the internal …
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Virulence potential and host response to Cronobacter sakazakii
… Furthermore, the ability of the organism to translocate through different cell lines, including Caco-2 and HBMEC, was assessed.
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Syntaxin 6- and Microtubule- Mediated Intracellular Trafficking Contributes to Golgi and Nuclear Translocation of Egfr
… evidence shows that these cell surface receptors translocate from cell surface to different cellular compartments, including the Golgi, mitochondria, endoplasmic reticulum (ER), and the nucleus to regulate physiological and pathological functions. Although some trafficking mechanisms have been …
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Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine
… to power conformational changes that unfold and translocate target proteins into the ClpP peptidase for degradation. X-ray crystal structures show that some ClpX subunits occupy nucleotide-loadable conformations and others occupy unloadable conformations. Furthermore, biochemical evidence …
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Apicomplexan Class XXVII Myosin - A Computational, Biophysical and Cell Biological Characterisation of PfMyoF in Plasmodium falciparum
… mechanoenzymes which either displace or translocate along actin filaments and typically function in a broad range of cellular activities such as membrane trafficking. Very little is known about the precise functions of the variety of myosins in P.falciparum or how they contribute to …
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Biology and Control of Eastern Black Nightshade, Palmer Amaranth, and Common Pokeweed, in No-Till Systems on the Eastern Shore Regions of Virginia and Maryland
… indicated that glyphosate does not readily translocate from treated foliage to other plant parts, which may contribute to shoot regeneration from taproots following glyphosate treatment. Taken together, this research highlights the important weed control issues, including resistant and …
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Sodium relations in pasture and fodder plants grown in New Zealand
… grown in New Zealand were able to absorb and translocate sodium from roots to shoots. In this respect plants can be classified into two distinct types according to the sites where sodium preferentially accumulates. Natrophilea: plants in which sodium readily accumulates in the leaf tissues. …
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Biochemical Analysis of the Molecular Factors of Leucyl-Trna Synthetase That Ensure Aminoacylation Fidelity
… In these cases, mischarged tRNA products are translocated approximately 30 A from the canonical aminoacylation core of LeuRS to an editing active site within a completely separate domain called CP1. A peptide has been identified within the CP1 domain of Escherichia coli (E. coli) LeuRS, which …
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Axon Guidance In The Mouse Olfactory System
… of the cytoplasmic domains of these proteins to translocate to the nucleus. Ectopic expression through transgenic analysis of one family member, Pcdh10, is sufficient to disrupt proper axon targeting of SR1 olfactory neurons. Based on this data we propose that the δ protocadherins are excellent …
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