Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"translational models"”.
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Effects of Electrical Stimulation and Testosterone in Translational Models of Peripheral Nerve Injury
<p>As functional recovery following peripheral nerve injury is dependent upon successful regeneration and target reconnection, combinatorial treatments that enhance different regeneration events may be required for recovery from severe injuries. The neurotherapeutic effects of electrical …
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Effects of Electrical Stimulation and Testosterone in Translational Models of Facial Nerve Injury
… to different pathophysiological outcomes, animal models that mimic the common sites of injury need to be developed so that potential therapies can be appropriately investigated. The extratemporal facial nerve axotomy model, in which the nerve is crushed at its exit from the skull, has been well …
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Development of translational models for intervertebral disc degeneration using a comparative approach for canine and human patients
… serve as highly relevant and ethical preclinical models for both human and canine IVDD. Chondrodystrophic (CD) and non-chondrodystrophic (NCD) breeds of dogs show different phenotypes of IVDD, each of which mimic phenotypes described for human patients. The main goal for this PhD research was to …
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Building a bridge between biophysics and neurobiology: A synergic approach to develop Alzheimer’s disease translational models and research tools
… thesis, I present the development of tools and models to make Aβ oligomers more accessible targets for drug discovery and preclinical setups. To contribute new tools towards unravelling the structural determinants of the cytotoxicity of oligomer species, in Chapter 3, I introduce a step-by-step …
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The Rat as a Translational Model of Neurotrauma: Primary Somatosensory Input and Imaging Biomarker Validation Following Spinal Cord and Peripheral Nerve Injuries
… and difficult to study, necessitating the use of translational models that provide standardizable and quantifiable models of injury. Rats are the most commonly used models of spinal cord (SCI) and peripheral nerve (PNI) injuries because their anatomy and physiology approximates that of humans, …
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Molecular Mechanisms of Opioid Use Disorder in Human Brain Models
… with no end in sight. While studies from animal models hint at widespread epigenetic and transcriptomic alterations of opioid drugs, the molecular consequences of long-term exposure to opioid drugs in human brain is still unclear, and human-centered translational models are necessary to discern …
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Single-molecule profiling of tau aggregates in tauopathies: From test tube to patient
… detailed profiling of aggregate morphology, post-translational modifications, and protein–protein interactions at the single-aggregate level. I demonstrate how these approaches distinguish tau aggregate properties across Alzheimer’s disease, primary tauopathies, and healthy controls, revealing …
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Characterizing canine dose from external beam irradiation
… Since dogs have been shown to be a valuable translational model for human radiation effects, accurate estimation of canine CT dose may permit future deterministic and stochastic radiobiological effect studies to be performed with canines on a much shorter time scale than similar studies with …
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Mitochondrial Metabolism in Ischaemia Reperfusion Injury
… drugs found to be promising in pre-clinical models fail to show efficacy in humans. Despite this, improving our understanding of the underlying pathophysiological mechanisms has supported the development of rational therapeutic approaches. Mitochondria are integral to IR injury, and the …
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DEVELOPMENTAL CONSEQUENCES OF GESTATIONAL CANNABIS EXPOSURE IN RAT ACROSS THE LIFESPAN
… Δ9-Tetrahydrocannabinol (THC) through injection models, which fail to accurately reflect human usage patterns. This dissertation aimed to develop a more representative model to study the pharmacokinetics, neurobehavioural, and biochemical effects of GCE via smoke exposure. Chapter 2 performs a …
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Targeting Mitochondrial ROS Production in Kidney Transplantation
… ROS production and ameliorate IRI in models of kidney transplantation. Herein, I show that the metabolic changes required for mitochondrial ROS production on reperfusion, including succinate accumulation and the depletion of adenine nucleotides, occur in grafts retrieved from both DBD …
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Characterising changes in pathology and function in clinically relevant models of spinal cord injury and using chondroitinase ABC gene therapy to promote repair
… enhance functional recovery in a number of SCI models in both rodents and larger animals through its enzymatic degradation of inhibitory chondroitin sulphate proteoglycans (CSPGs). However, ChABC treatment has met with limited success in more traumatic, translational models of SCI, such as …
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Regulatory Mechanisms Underlying the Differentiation of Mesenchymal Stem Cells to Endothelial Cells
… endothelial growth factor (VEGF) — 165 in vitro. Translational models have demonstrated that differentiated BM-derived MSCs can be transplanted into the site of angioplasty-induced endothelial injury. However, re-endothelialization by VEGF-induced BM-derived MSCs remains a complex clinical …
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Preclinical evaluation of dissolvable microarray patches for allergy treatment: key factors governing in vitro and in silico assessment
… where the lack of predictive, MAP-specific translational models remains a major limitation. To address these limitations, this thesis aimed to enhance the preclinical evaluation of dissolvable MAP by systematically investigating the physicochemical, biopharmaceutical, and pharmacokinetic …