Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"translational animal model"”.
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Safety of Slow Release Lipopolysaccharide (LPS) Pellet in a Swine Model and Development of an Exogenous Reference Control for Real Time PCR
… provide some clues to the development of CIAO. Translational medical research relies upon animal models for studying complex human conditions, such as CIAO. Simpler rodent models assist in unraveling certain biological connections, but their predictive value for devising appropriate and …
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MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
… in human NASH patients. Using a diet-induced animal model of NASH and targeted proteomics and metabolomics it was found glycine N-methyltransferase reduction in NASH leads to an accumulation of S-adenosylmethionine, activation of polyamine metabolism, and production of oxidative stress. …
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Modeling Uric Acid Kidney Stones Disease in D. melanogaster using RNAi and Dietary Modulation
… or uric acid kidney stones in humans using our model. We found that allopurinol and potassium citrate reduced uric acid kidney stone formation in our model. We then tested whether compounds predicted to reduce uric acid and uric acid kidney stones in humans, but not currently used as treatments, …
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Cathepsin S as a mediator of acute lung inflammation
… the status of CTSS in the context of ARDS and models of ARDS. These investigations revealed that CTSS levels and activity were elevated in the lungs of patients with ARDS, and that elevated CTSS activity was also detectable in the plasma of these patients. Elevated pulmonary CTSS activity was …