Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"translation regulation"”.
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Nuclear binding and translation regulation by FMRP through novel associated protein and putative RNA helicase MOV10
… X mental retardation protein and its role in translational regulation. More specifically, I began my studies trying to understand the role of FMRP in the nucleus. This work is novel and interesting because the nuclear role of FMRP has not been widely studied. FMRP is an RNA binding protein …
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The Role of Post-Translation Regulation of Twist Expression In The Tumor Progression of Squamous Cell Carcinoma of Head and Neck
Squamous cell carcinoma of head and neck (SCCHN) is the tenth most common cancer in the world. Unfortunately, the survival of patients with SCCHN has not improved in the last 40 years. Therefore new targets for therapy are needed, and to this end we are studying signaling pathways activated by IL-6 …
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Novel Functions for Neuronal RNA Processing Bodies in the Control of Axon Terminal Growth in Drosophila Melanogaster
… that might have function in FMRP mediated translation regulation. Interestingly, a luciferase-based translational repression tethering assays in <em>Drosophila</em> Schneider 2 (S2) cells showed the function of GW182 in FMRP-mediated translation regulation.</p>
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Neuronal FMRP: facilitating learning in a critical brain network for zebra finch song acquisition and regulating synaptic miRNAs spatio-temporally
… of FXS present with abnormalities in protein translation. This work will address the roles of FMRP in the development of a neural circuit for vocalization, and in protein translation regulation via the microRNA (miRNA) pathway. Humans are vocal learners, meaning we must hear normal adult …
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Ribosomal Proteins RPLP1 and RPLP2 are Host Factors Critically Required for Flavivirus Infectivity by Promoting Efficient Viral Translation Elongation.
… that are crucial host factors required for translation of flaviviruses and efficient flavivirus infection of human cell lines and Aedes aegypti mosquitoes, which are natural vectors for these viruses. We hypothesized that RPLP1/2 are accessory ribosomal proteins that function to promote …
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Determinants of translational efficiency in Saccharomyces cerevisiae
… is to elucidate the mechanisms that govern translational efficiency (TE) - the amount of protein produced from each molecule of mRNA. While the mechanisms regulating the TE of a few specific messages are well understood, the general contribution of translational control to differences in …
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Iron regulates mRNA translation initiation through RNA iron responsive element (IRE)
… with IRE-RNA. Previous models of IRE-mRNA translation regulation concentrate on Fe-S binding to IRP and IRP degradation after release from IRE-RNA. These models lack information on the details of decreasing IRE-RNA/IRP protein binding with iron concentration elevation. This research shows …
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Stochastic modeling of inducible logical gates in Escherichia coli
… interactions involved in transcription, translation, regulation and induction in order to quantify the influence of each individual interaction on the behavior of the system. Thus, we can quantitatively analyze the behavior of the systems, and better understand why the systems behave as …
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Elucidating the role of SRSF1, a prototypical splicing factor, in liver physiology
… in RNA biology. This ranges from mRNA transport, translation regulation, non-sense mediated decay and even processing of miRNA. Therefore, it is not surprising that SRSF1 is vital for the survival of the cell. While deficiency in most tissues results in organ failure, the liver has the remarkable …
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Genetic regulation of maize floral development - insights from the transcriptome and translatome
… gene expression. Understanding gene expression regulation in maize floral development is critical to regulate floret fertility in other grasses and potentially useful to engineer more productive cereal crops. In this work, I focus on gene expression regulation at transcriptome and translatome …
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An E. coli small RNA inhibits translation initiation from a distance
In bacterial systems, small RNA (sRNA)-dependent translational repression is commonly carried out via sRNA-mRNA base pairing interactions near the Shine-Dalgarno (SD) region. In this so-called “canonical” mechanism, the sRNA is the direct regulator; it competes with the initiating ribosomes while …
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Novel Insights into the Regulation of Autophagy in Saccharomyces Cerevisiae
… that are also involved in rRNA processing and translation initiation. Interestingly, IML1, NPR2, NPR3 and PBP1 are also important for Rli1p-depletion-induced mitophagy. These results strongly suggest the mechanistic link between SL-induced autophagy and ribosome biogenesis or translation …
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Functional genomics studies of human brain development and implications for autism spectrum disorder
… of brain regions. Consequently, the dysregulation of complex gene networks in the developing brain is believed to underlie many neurodevelopmental disorders, such as autism spectrum disorders (ASD). Autism has a significant genetic etiology, but there are hundreds of genes implicated, …
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Regulation of the Mannose PTS Operon by the small RNA SgrS
… manXYZ. Analysis of manXYZ mRNA stability and translation in the presence and absence of SgrS indicate that manXYZ is regulated by SgrS under stress conditions and when SgrS is ectopically expressed. In vitro footprinting and in vivo mutational analyses showed that SgrS base pairs with manXYZ …
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Investigation Of Posttranscriptional Regulation After Global Brain Ischemia And Reperfusion Injury
… in reperfused neurons and to characterize global translation regulation, we 1) prevented mRNA granule formation in reperfused neurons or induced mRNA granules in uninjured neurons by pharmacological manipulation polysomes, 2. studied potential HuR posttranscriptional regulation mechanisms of …
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Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks In Yeast
… uncovered a unique role for Fes1 in Ssa-mediated regulation of the cytosolic heat shock response, while revealing no significant contributions from Snl1 and Sse2. These findings suggest that NEFs do have overlapping functions, but their distinct associations with the Hsp70s as well as unique …
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Gene expression during the host-bacteria interaction
… expression is incomplete without also looking at translation. Translation regulation allows for a more rapid and dynamic response than transcriptional regulation and it is well characterized that translation is highly modulated under stress, including in infection. Where there are many studies on …
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Characterization of the Role of Differential Gene Expression and RNA Editing in Drosophila Tonic and Phasic Motoneuron Diversity
How differential regulation of gene expression programs across neuronal subtypes leads to their unique morphology, membrane excitability and synaptic properties is poorly understood. Protein expression and function within neurons depends on numerous transcriptional and post-transcriptional …
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Regulation of Cell Adhesion By The Ferm Proteins, Ptpn14 and Merlin
… and activation of Slug. Similar to the regulation of the AJ by PTPN14, we examined another FERM domain protein, Merlin, and found that specific post-translational modifications in its unique N-terminal region regulate distinct AJ-mediated activities. Mutation of a single serine residue …
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