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Showing 1 to 12 of 12 for “"translation rates"”.
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Studies on Translation Speed and Protein Folding Efficiency in Bacteria and Eukaryotes
… in bacterial systems. Polypeptide synthesis rates are faster in bacteria than in eukaryotes, but the effects of general variations in translation rates on protein folding efficiency have remained largely unexplored. By employing E. coli cells with mutant ribosomes whose translation speed can …
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Post-transcriptional regulation of poly(A) binding proteins direct multiple facets of cardiac development and hypertrophy
… However, during adult cardiac hypertrophy, translation rates increase. This suggests a dynamic, tissue specific mechanism for regulating translation rates in the mammalian heart. In this dissertation, the discovery and characterization of multiple mechanisms for regulating gene expression …
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Translation rate is genetically encoded and influences protein folding
… codons allow for faster or more efficient translation, whereas the presence of others result in slower translation rates. The presence of these different types of codons along a message is postulated in turn to confer variable rates of emergence of the nascent polypeptide from the ribosome, …
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Characterization of the 5̕ untranslated region ( 5̕ UTR) of the alcohol oxidase I (AOX I) gene in Pichia pastoris.
… led to an increase or decrease in the rate of translation. Deletions had a variable effect on β-galactosidase expression, whereas additions decreased expression but not in a linear fashion. Final confirmation was performed using Northern analysis to ensure that the effects were due to …
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Regulation of Mnk1 by p38α MAPK in Stress Mediated Translation Initiation
… pathways control protein synthesis by modulating translation initiation factors. Map Kinase Integrating Kinase 1 (Mnk1) relays signals to its major downstream target eIF4E. Activation of Mnk1 and subsequent phosphorylation of eIF4E results in changes in translation rates for subsets of mRNAs. Both …
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The function of PAB1 in translation and in PUF3 dependent deadenylation
… protein (PAB1) in deadenylation and translation is well known. How PAB1 inhibits deadenylation and promotes translation is not well understood. I have analyzed PAB1 variants, containing entire domain deletions and substitutions of yeast residues with human residues. Chapter I …
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Determinants of translational efficiency in Saccharomyces cerevisiae
… is to elucidate the mechanisms that govern translational efficiency (TE) - the amount of protein produced from each molecule of mRNA. While the mechanisms regulating the TE of a few specific messages are well understood, the general contribution of translational control to differences in …
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Mechanisms of persistent translation arrest following global brain ischemia and reperfusion
<p>ABSTRACT</p> <p>MECHANISMS OF PERSISTENT TRANSLATION ARREST FOLLOWING GLOBAL BRAIN ISCHEMIA and REPERFUSION</p> <p>by</p> <p>JILL T. JAMISON</p> <p>December 2011</p> <p>Advisor: Donald J. DeGracia, Ph.D.</p> <p>Major: Physiology</p> <p>Degree: Doctor of Philosophy</p> <p>The information …
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The Sequence Landscape of Bacterial Genes is Shaped by Long-Range mRNA Folding
… In bacteria, a major regulator of mRNA decay and translation rates is accessibility of the ribosome binding site (RBS) to the ribosome. Sequences in the mRNA’s 5´ untranslated region (UTR) complementary to the RBS can decrease gene expression by base pairing and occluding ribosomes from binding. …
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CHARACTERISATION OF Y-BOX PROTEIN 3 (MSY3) IN THE DEVELOPING MURINE CENTRAL NERVOUS SYSTEM
… gene expression from transcription to translation. This study aimed to examine the expression of mouse Y-box protein 3 (MSY3) in the developing nervous system and elucidate its putative role in regulation of proliferation of progenitor cells. As presented in this work, the MSY3 protein …
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Genetic Engineering as a Tool to Investigate Mitochondrial Gene Expression
… aspects of the processes of transcription and translation are not fully understood. Given the recent advancements in genome engineering in mitochondria, in particular the development of base editing, it is now possible to investigate these processes in more detail than ever before. Using these …
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Wave-induced sediment transport on an estuarine intertidal flat
… where Ww declined as a result of high tidal-translation rates across the middle flats. Allen's ( 1971) model describes spatial trends in waves and tides across intertidal flats; wave activity at the bed increases at higher elevations while tidal currents decrease. The Wiroa data reveal a more …