Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"transition-state analogues"”.
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Development of transition state analogues targeting chitinases and oligosaccharyl transferase
… pathways, they are believed to share similar transition states involving an oxocarbenium ion. To understand the mechanism of OT and discover potent and selective inhibitors against different chitinases, our intent was to utilize the common transition state analogue for both enzymes and …
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Trifluoromethyl ketones: Potential insecticides towards Anopheles gambiae
Malaria continues to cause significant mortality in sub-Saharan Africa and elsewhere, and existing vector control measures are being threatened by growing resistance to pyrethroid insecticides. With the goal of developing new human-safe, resistance-breaking insecticides we have explored several …
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Enzyme-Catalyzed Phosphoryl Transfer Reactions: Energetics of Transition States and Vanadate Analogues in Aqueous Solution
… solution to address the use of Vanadium(V)-based transition state analogues in the study of DNA Polymerase, β-phosphoglucomutase (β-PGM), and Hexose Phosphate Phosphatase (HPP) -catalyzed phosphoryl transfer reactions. This work seeks to add to the growing body of theoretical work that addresses …
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Synthetic approaches to the understanding of DNA nucleobase methylation
… work explores the possibility of using stable analogues of N7-methyl-dG to study the polymerase bypass. The chemical synthesis of N7-methyl-9-deaza- dG (^{7Me9C}dG) has been developed and the nucleoside has been successfully incorporated into oligonucleotides. Thermal melting studies show that …
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Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism
… many human cancer tissues, including breast, prostate, and lung cancer tissues, it plays an important role in oncogenesis, making its study vital for the development of anti-cancer agents. Many inhibitors have been discovered for Pin1, including 1) several classes of designed inhibitors such as …
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Substituted aryl glycosides as probes of the mechanism of spontaneous ad enzyme-catalyzed glycoside hydrolysis
… of the oxocarbonium ions generated at the transition state, which appear to be principally a function of field effects (as predicted by the Kirkwood-Westheimer hypothesis) exerted by the ring substituents at 05 and Cl. Differences in the rates of hydrolysis between different series of …
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Polar Tris(pyrazolyl)borates for the modeling of Zinc metalloenzymes in aqueous solution
… revealed to form dimeric species in the solid state due to pyridine coordination to zinc, and to interact with the solvent molecules in a similar manner as it occurs in the resting state of zinc metalloenzymes. [Tp4'Py,MeZn·OH2]ClO4 was found to be an appropriate reagent for the cleavage of …