Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"transition metal-catalyzed"”.
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TRANSITION METAL CATALYZED CROSS-COUPLINGS OF ALKYL SULFONE ELECTROPHILES
… as electrophiles in both nickel and palladium catalyzed cross-coupling reactions. First, we developed a nickel-catalyzed Suzuki–Miyaura cross-coupling of π-extended tertiary benzylic and allylic sulfones with arylboroxines. A variety of tertiary sulfones were reacted to afford quaternary …
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Studies of Novel Transition-Metal-Catalyzed Oxidative Coupling Reactions
Transition-metal-catalyzed oxidative coupling reactions are important tools for the construction of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds from simple starting materials. A series of novel and synthetically useful reactions have been developed and are herein described.
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Transition Metal-Catalyzed Preparation and Functionalization of Nitrogen-Containing Heterocycles
… that utilize catalytic quantities of transition metals continue to be developed, and have paved the way to enable rapid increases in molecular complexity with far less effort than previously required. The active ingredient in traditional cross-coupling reactions is a catalytic quantity …
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Transition metal-catalyzed cross-coupling reactions of functionalized organometallic reagents
… have been found for a versatile nickel-catalyzed crosscoupling reaction in the presence of an electron deficient styrene promoter, allowing for the first time: · effective coupling of readily available functionalized alkylzinc halides and benzylic zinc bromides with functionalized alkyl …
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Development and application of transition metal-catalyzed cross-coupling reactions
Chapter 1. PALLADIUM-CATALYZED REGIOSELECTIVE HYDRODEBROMINATION OF DIBROMOINDOLES A novel approach to the selective preparation of 4-bromoindoles has been developed via a Pd-catalyzed reaction. A variety of 4,6-dibromoindoles, which are prepared via Cu-catalyzed chemoselective C-N bond-forming …
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Late transition metal catalyzed C-N and C-C bond forming reactions
New methods for the palladium-catalyzed amination of aryl halides are described. Key to these is the development of new catalysts and reaction conditions for these transformations. Initially, P(o-tol)3 ligated palladium catalysts were investigated but gave way to systems that used chelating …
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Development of novel transition metal-catalyzed cross-coupling reactions and applications thereof
Chapter 1 The first example of Pd(0)/(II) catalyzed fluorination of aryl bromides is reported herein. Based on these data, an analogous method was developed for the fluorination of aryl triflates. The reaction proceeds under mild conditions and represents the first report of reductive elimination …
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Development of transition metal-catalyzed C-S and C-C cross-coupling reactions
The transition-metal-catalyzed carbon-carbon and carbon-heteroatom bond forming reactions are important and fundamental transformations in synthetic organic chemistry. These reactions have been widely used for a variety of cross-coupling reactions of aryl halides in the processes of C?C, C?N and …
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Development of Transition Metal-Catalyzed Borylation Protocols using Symmetrical and Unsymmetrical Diboron Reagents
… since the FDA approval of Velcade©. As a result, transition metal-catalyzed protocols to incorporate boron reagents into unsaturated compounds have been extensively researched. While an abundance of literature protocols have been reported, the majority utilize harsh reaction conditions in …
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Study of Bis-Imidazol-2-Ylidines as Ligands for Transition Metal Catalyzed Coupling Reactions
… carbenes as ancillary ligands in the palladium-catalyzed amination reaction of aryl halides was investigated to determine functionality of the carbenes. Alternative procedures to prepare the key intermediates in the synthesis of the bisimidazol- 2-ylidines were developed. In this study the aryl …
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Transition metal-catalyzed olefin functionalization for highly regio-, enantio-, and chemoselective C–X bond formation
… This thesis specifically focuses on using transition metal-catalysis to form C–X bonds from C–C double bonds with high degrees of regio-, chemo-, and stereoselectivity. In chapter 1, a regiodivergent Rh-catalyzed hydrothiolation of allyl amines to form 1,2- or 1,3-aminothioethers with …
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Development of new transition metal-catalyzed carbon-fluorine, carbon-nitrogen, and carbon-carbon bond forming processes
Chapter 1. Palladium-Catalyzed Fluorination of Cyclic Vinyl Triflates: Dramatic Effect of TESCF₃ as an Additive A method for the synthesis of cyclic vinyl fluorides with high levels of regiochemical fidelity has been achieved by Pd-catalysis employing a new biarylphosphine ligand and TESCF₃ as a …
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New reactivity and selectivity in transition metal-catalyzed C-C and C-N bond forming processes
Part I. Palladium-Catalyzed Carbon-Carbon Bond Forming Cross-Couplings Chapter 1. Ligand-Controlled Palladium-Catalyzed Regiodivergent Suzuki-Miyaura Cross-Coupling of Allylboronates and Aryl Halides An orthogonal set of catalyst systems based on the use of two biarylphosphine ligands has been …
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Development of New Synthetic Methods for Transition Metal-Catalyzed Organic Reactions and Synthesis of Curcumin-Based Adducts
… on the development of synthetic methodologies of transition metal-catalyzed reactions. Transition metal-catalyzed carbon-carbon bond-forming reactions, such as Suzuki coupling reactions and addition reactions, are among the most powerful and versatile transformations in organic synthesis. My work …
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Electronic Effects in Multidentate Pyridinol and N-Heterocyclic Carbene Based Ligands for Transition Metal Catalyzed Carbon Dioxide Reduction
… we can design better catalysts using various transition metals. Multidentate ligands composed of pyridyl bound to N-heterocyclic carbene rings are a synthetically flexible scaffold capable of testing our hypotheses. The systematic tuning of this scaffold will elucidate the factors necessary to …
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Exploration of Transition Metal Catalyzed C−C and C−N Bond Formation to Access Synthetically Elusive Small Molecules
… 1,3-dienes using the ruthenium hydride catalyzed intramolecular silylvinylation of alkynes under 80 psi of ethylene gas. This strategy affords a single diene isomer, is applicable to substrates with aryl and alkyl substitution at the propargyl and homopropargyl positions, and has been …
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The reaction pathways of hydrogen peroxide in the presence of scavengers and its transition metal catalyzed oxidation of disulfide bridge containing peptides
… the enthalpy, entropy and free energy of the transition states of the formation and breakdown of the intermediate have been calculated. The metal-catalyzed pathway of hydrogen peroxide is dealing with the effect of hydroxyl radicals created by the Fenton reaction and their potential to oxidize …
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Methods for Directed C–O Bond Functionalization of Esters and Acyl Equivalents
… developing and studying the mechanisms of new transition metal-catalyzed acyl transfer reactions using substrates at the ester oxidation state. New methods discussed include steric-controlled arene acylation via sequential C–O/C–H bond activation and a Suzuki-Miyaura cross coupling using …
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Stereoselective Intramolecular Rhodium(I)-Catalyzed [(3+2+2)] Cycloaddition Reactions of Alkylidenecyclopropanes (ACPs) for the Concise Synthesis of Bridged Tricyclic Products
Transition metal-catalyzed higher-order [m+n+o] cycloadditions are an important class of reactions for constructing elaborate carbocycles and heterocycles in a highly convergent manner. In particular, cycloadditions with alkylidenecyclopropanes (ACPs) as three-carbon synthons offer a versatile …
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2-Silicon-Substituted 1,3-Dienes: Participants in Diels-Alder Chemistry and Metal-Mediated Processes
… to our research are the Diels-Alder reaction and transition-metal-catalyzed cross-coupling reactions. Issues that arise in these processes include poor efficiency and poor stereoselectivity. My dissertation research has centered around the synthesis and use of 2-silicon-substituted 1,3-dienes to …
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