Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"transition metal catalysis"”.
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Transition-metal catalysis of cyclocarbonylation and cycloisomerization reactions
… Chapter 2. The first example of an early transition-metal-catalyzed enyne cycloisomerization is described. Titanocene dicarbonyl was shown to catalyze the cycloisomerization of enynes and dienynes to 1,4-dienes and allylic allenes, respectively. Examination of the scope of the reaction …
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C(sp3)-H aminations under first row transition metal catalysis
… and manganese catalysts were first explored for metallonitrene-mediated C—H amination reactions, the majority of synthetic advances in the field have been with noble metal dirhodium carboxylate catalysts. These catalysts are highly reactive and have collectively displayed the ability to …
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New methodologies and approaches to reaction discovery in transition metal catalysis
… of the pinacol boronate is slow, and the transmetallation of the pinacol boronate with an intermediate palladium hydroxide complex occurs rapidly without generation of the boronic acid. This C-H borylation and cross coupling sequence can be conducted on small or large scale and does not require …
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First-principles transition-metal catalysis : efficient and accurate approaches for studying enzymatic systems
… of functionalized cobalt porphyrins on a metal slab support and the reaction mechanism of the halogenating non-heme Fe(II) enzyme, SyrB2. Efficient and accurate study of transition metal chemistry paves the way for predictive and targeted design of catalysts that provide unique solutions …
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Synthesis and application of chiral dienes and chiral imidates as ligands for transition metal catalysis
In this dissertation, two main ligandclasses have been studied: chiral diene ligands and chiral imidate ligands. We developed a novel route to synthesize chiral disubstituted bicyclo[2.2.1]heptadienes (R= i-Bu, c-Hex, Benzyl and allyl) starting from enantiomerically pure bistriflate. The …
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The Synthesis and Application of a Chiral Sulfonated Phosphine Ligand to Asymmetric Transition-Metal Catalysis
… and its subsequent application in asymmetric transition-metal catalysis. sSPhos is a dialkylbiaryl phosphine ligand bearing a sulfonate group. This sulfonate group can engage in non-covalent interactions, allowing sSPhos to influence site- and enantioselectivity when employed as a ligand for …
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Development of the cross-coupling of alcohols with olefins via positional tuning of the counterion in transition metal catalysis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Cyclopentadienyl ruthenium sulfide carbonyls and thiophene activation by iron and rhodium
… (HDS), one of the largest applications of transition-metal catalysis. However, the specific mechanism for the process is not well understood. This thesis addresses certain aspects of HDS research from an organometallic perspective.
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Controlling the Regio- and Enantioselectivity of Iridium-Catalysed Arene Borylation Using Sulfonated Bipyridine Ligands
… them to control selectivity in small molecule catalysis. Two types of interaction that are frequently exploited are hydrogen bonding and ion-pairing. This thesis details efforts to use these interactions to control both the regio- and enantioselectivity of iridium-catalysed arene borylation, an …
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Cross Coupling of Alkenyl Gold Complexes with Alkyl Electrophiles and Nickel Catalyzed Hydroarylation of Alkenes
Transition metal catalysis is a powerful strategy for the construction of organic molecules. The development of novel methods in this field can help improve the speed and efficiency with which we synthesize complex organic molecules and broaden the scope of accessible products. Here we describe the …
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Engineering novel tandem reactions using organometallic catalysts and metalloenzymes
Organometallic chemistry and bioinorganic chemistry are two prominent sub-disciplines of chemistry. Complexes of the transition metals are prominent components of both disciplines. On the one hand, considerable efforts in transition-metal catalysis have culminated in practical and efficient …
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Exploration of mild and selective hydrozirconation reactions facilitated by zirconocene hydride catalysts generated in Situ.
Metal hydride reagents are widely used in organic synthesis for the reductive functionalization of π-systems. In recent decades, the surging cost of precious transition metals has prompted the search for alternative hydrometalation approaches, especially innovative methods using first-row and early …
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Organophosphorus-Catalyzed Reductive Functionalization of Nitrocompounds via P(III)/P(V) Redox Couple
… in reaction classes heretofore dominated by transition-metal catalysis and suggesting potential opportunities for organophosphorus catalyst optimization.
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HYPERVALENT IODINE-MEDIATED HETEROCYCLIC GROUP TRANSFER REACTIONS TO OXIDATIVE OLEFIN DIFUNCTIONALIZATION
… emerged as important cross coupling handles for metal-catalyzed processes. Unfortunately, current methods to access pyridinium salts are limited; they require harsh conditions, rely on the presence of an amine functional handle, and are not amenable to diverse structural variation. In Chapter 1, …
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EXPLORING UNPRECEDENT SYNTHETIC ROUTES FOR CHIRAL AMINO DERIVATIVES
… through the integration of photoredox catalysis, organocatalysis, transition-metal catalysis, and continuous-flow chemistry. The work explores the synthetic potential of light-driven processes to access reactive open-shell intermediates under mild and sustainable conditions, enabling …
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Alkyl-heteroatom Bond Forming Reactions from the Late Transition Metals
… formation is a potential high value reaction in transition metal catalysis, however, only a handful of examples of this fundamental coupling reaction step have been reported. Presented in this thesis are new efforts to promote this challenging reaction. Group 9 and 10 metals bound by the pincer …
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Ruthenium-Catalyzed Transformations for the Synthesis of Conjugated Dienes
<p>A general description of transition metal catalysis of alkynes and alkenes for the formation of conjugated dienes is briefly discussed. Specifically, a synopsis of ruthenium-hydride catalysis for the formation of 1,3-dienes is presented. </p> <p> The development of the trans-silylvinylation of …
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The development of novel organocatalytic and transition-metal catalysed methodologies for amide bond formation
… corresponding oxazolidinone moieties. The use of transition-metal catalysis has also been employed to facilitate amide bond formation. Utilising silanoate-derived imidate salt species, synthesised from the corresponding nitriles as amide surrogates, a Buchwald-Hartwig amidation methodology has …
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NEW TRANSITION METAL CATALYSTS FOR CARBON-CARBON BOND FORMATION
… they enable have been the driving force of organometallic chemistry for the past decades. Since their inception, organometallic complexes have been applied to the formation of carbon-carbon bonds both as reagents and catalysts. Ligands and complexes tailored for a particular reaction have …
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