Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"transit amplifying cells"”.
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Adult Neural Stem Cells and Their Perivascular Niche
Stem cells reside in specialized niches that support their selfrenewal and differentiation. A balance between intrinsic and extrinsic signals mediates stem cell quiescence, activation and proliferation. In the mammalian subventricular zone (SVZ), the stem cells are a subset of GFAP+ astrocytes. A …
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Neural Stem Cells in Brain Tumor Development
… models indicated a central role for neural stem cells and stem cell-like cancer cells in malignant astrocytoma formation. Using stereotactic viral cre-mediated approach, we demonstrate that targeting of tumor suppressor inactivating mutations in the subventricular zone (SVZ) where neural stem and …
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Epigenetic regulation by 5-hydroxymethylcytosine in atopic dermatitis and psoriasis and its implications for epidermal stem cell behavior
… ultimately organ homeostasis. Keratinocyte stem cells (KSC) maintain a healthy skin barrier by replenishing dead keratinocytes lost during daily turnover, injury, or pathological disturbances. In atopic dermatitis (AD) and psoriasis (PS), there is marked psoriasiform hyperplasia of the epidermis, …
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The developmental transcriptional landscape and organizing function of the sieve element in the root meristem
… in sieve elements, specialized tube-like cells in the phloem. While several regulators of sieve element differentiation have been described, many remain unknown. Furthermore, the temporal cascade of differentiation regulation remains unclear due to limited resolution in published data. In …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
… for recruitment and activation of immune cells. Chronic inflammation of the airways due to prolonged or repeated exposure to noxious agents can result in epithelial remodeling and fibrosis that leaves the airways more susceptible to infection due to disruption of innate immune processes. …
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Spatiotemporal dynamics of cell division in intestinal homeostasis
… homeostasis is governed by fate choices of stem cells residing in the intestinal crypt base. This must involve niche-specific co-ordination of cell division to guarantee that epithelial cells divide at the right time and place. These mechanisms operate to ensure precise control of the numbers of …
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Regulatory Proteins in Progenitors and Differentiated Cells of the Human Prostate
… proteins in mature and differentiating cells of the adult prostate, including the benign and malignant prostate. In this thesis, I provide evidence for epithelial renewal in response to prostate tissue culture, and for basal and epithelial stem cell (SC) recruitment leading to an …
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New insights into cornea-lens regeneration in Xenopus laevis: the role of Wnt/beta-catenin signaling and the regenerative capacity of the limbal region
… the molecular mechanisms that drive residual cells in a damaged or diseased tissue to proliferate and differentiate to replace lost structures that we will have the knowledge to attempt to recapitulate these regenerative processes in other species, including our own. Towards this end, the …