Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"transient receptor potential"”.
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Role of Transient Receptor Potential (TRP) Channels in Nociception
Transient receptor potential (TRP) channels play an important role in sensory and nonsensory functions. TRPVanilloid 1 and TRPVanilloid 4 are proposed to be involved in inflammation-induced pain. TRPV1 is extensively studied and it is specifically involved in inflammatory thermal hypersensitivity. …
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Role of transient receptor potential channels in mammalian oviduct and uterine epithelia
… calcium channels, specifically, members of the transient receptor potential (TRP) channel superfamily and the Na+/Ca2+ exchanger. TRP channels are an important class of calcium channels with more than 28 identified members and their potential involvement in calcium transport in uterus and …
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Investigating The Role Of Transient Receptor Potential Ankyrin One (TRPA1) In Cardiovascular Regulation
… PhD used TRPAl WT and KO mice to investigate the potential for TRPAl to alter peripheral artery tone and the implications of this on systemic blood pressure. I also studied the development of angiotensin II induced hypertension and associated pathologies. Wire myography using murine TRPAl WT and …
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Assessing the Role of the Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channel in Visceral Sensation
… to identify safe and efficacious treatments. Transient receptor potential (TRP) channels represent a therapeutic target for abdominal pain that may have fewer side effects and potentially provide efficacious relief from pain. Various TRP channels contribute to abdominal pain in preclinical …
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The Transient Receptor Potential Melastatin 4 Channel: A New Player in Urinary Bladder Smooth Muscle Function
… is urgently needed. This study presents the transient receptor potential melastatin 4 (TRPM4) channel, a Ca2+-activated, monovalent cation selective channel as a promising novel target for OAB therapies. Until now, the expression and function of the TRPM4 channels in DSM has not yet been …
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Transient receptor potential melastatin member 4 is the executioner protein for anticancer drug-induced necrotic cell death
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Role of the Transient Receptor Potential Channels in Modulating Prefrontal Cortical Excitability and the Behavioral Responses to Cocaine
… a prolonged depolarizing response to Gq-coupled receptor activation, which produces a period of heightened excitability of the cell following brief bursts of action potential activity. This burst triggered delayed depolarization enables the cell to convert subthreshold inputs into persistent …
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Structural Analysis of Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channel Protein and Proline Mimics using Computational Techniques
… I</strong></p> <p><strong></strong>The Transient Receptor Potential (TRP) family of ion channels encompasses more than 30 members, which are expressed in many different tissues and cell types.<sup>1</sup><strong> </strong>Transient Receptor Potential Vanilloid Type 1 (TRPV1) is part of …
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Studies on transient receptor potential vanilloid subtype 1 (TRPV1)-mediated degeneration of mesencephalic cellsin vivo and in vitro
"Transient receptor potential vanilloid subtype 1 (TRPV1, also known as VR1) has an oligomeric structure formed by subunits having six transmembrane segments with a pore domain formed by the fifth and sixth transmembrane regions. This receptor is a nonselective cation channel activated by the …
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… of PD. Recent evidence implicates the transient receptor potential vanilloid subtype 1 (TRPV1) leads to neuroprotective effects by anti-inflammtory action. The main purpose of this thesis is to investigate the functional effects of capsaicin (CAP), the TRPV1 agonist, in LPS-induced in …
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Characterisation of substance P and transient receptor potential melastatin channel messenger RNA and protein expression in acute and chronic neurological disorders.
… the administration of an NK-1 (neurokinin-1, SP receptor) antagonist. In addition, studies using a rat model of PD have similarly established a putative role for SP in this disease process. Transient receptor potential melastatin (TRPM) channels are a diverse family of ion channels, many of which …
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Activation of the Transient Receptor Potential Vanilloid-1 (TRPV1) channel mediates Extracellular Signal Regulated Kinase (ERK) phosphorylation via Beta-arrestin-2 signaling
The Transient Receptor Potential Vanilloid 1 (TRPV1) channel plays a pivotal role in pain sensation and transduction under physiological and pathophysiological conditions. Recent work highlighted a possible role for β-arrestin-2, a scaffolding protein that mediates G-protein coupled receptor …
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Targeting Sequence and Function-Dependence of Subcellular Localization of Transient Receptor Potential Mucolipin Channels and Characterization of Engineered Molecule Probes For Detecting Lysosomal Calcium Release
… TRPML3 are members of the mucolipin subfamily of Transient Receptor Potential (TRP) channels. They have been implicated in endolysosomal functions such as divalent cation release, luminal pH regulation, autophagy and vesicle trafficking. Interestingly, whereas TRPML1 is almost extensively …
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Nociception and the Experience of Pain Signaling Due to Nerve Damage
… the use of addictive medication can have the potential to change the course or modern medicine known today. Through the use of zebrafish, this thesis provides a preliminary understanding in pain signal blocking. Three distinct genes have found to be associated with perceiving pain, which …
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Eisenia hortensis Detects Chemesthetic Irritants through TRP Channels
… earthworms with allyl isothiocyanate, a common Transient Receptor Potential 1 (TRPA1) channel agonist, we hypothesized that earthworms possess TRPA1-like channels. We examined whether the earthworm Eisenia hortensis possesses TRPA1-like channels, as well as other TRP channel members. We assessed …
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The Role of Pkd1 in Mouse Inner Ear Hair Cells
… flow-sensor in the kidney. As a member of the transient receptor potential (TRP) family, PC-1 has also been hypothesized to play a role in the elusive mechanoelectrical transduction (MET) channel in inner ear hair cells based on PC-1 role of fluid flow sensing and calcium uptake into renal …
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Chemesthesis in the Earthworm, Lumbricus terrestris: The search for TRP Channels
Chemesthesis is the chemical stimulation of receptors on somatosensory neurons usually by noxious chemicals leading to irritation. Transient receptor potential channels play a major role in detecting chemesthetic stimuli and are found in a wide variety of organisms, from yeast to humans. Currently, …
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