Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"transgenic rescue"”.
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In Vivo Identification of SLE1B: LY108 Mediates Autoantibody Production
… further narrow the interval, we utilized a BAC transgenic rescue approach whereby BACs carrying the lupus-resistant B6 alleles were bred to B6.Sle1b mice to identify the region mediating ANA suppression. One BAC carrying Cd84 and Ly108 suppressed autoantibody production. We then generated BAC …
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The extracellular matrix of the nematode Caenorhabditis elegans : a model to study the role of cell-matrix interaction in animal development.
… (PTB) domain of a cytoplasmic protein. The transgenic rescue animals displayed defects in muscle morphology, gonad migration, high male number, and tail morphology. Further analyses revealed that males from pat-3(Y804E) transgenic mutant and him-4/hemicentin share similar phenotypes such as …
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Common Alleles of the SLAM/CD2 Family are Associated with Murine Lupus
… analysis. We have instead turned to a BAC-transgenic rescue strategy by which to localize the gene to a single B6-derived BAC, by its ability to complement the ANA-production phenotype and rescue autoimmunity in B6.Sle1b mice. We believe the strategy is feasible because Sle1b has a strong …
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Construction of a COL11A1 Transgene Vector
… lethality. Objective: 1) To construct a transgenic expression vector designed to express a human COL11A1 cDNA in a cartilage-specific manner. This transgene will be used in future studies to correct the type XI collagen defect in homozygous cho mice. 2) To place the cDNA in an in vitro …
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Characterization of the Genes Essential for Mouse Spermatogenesis
… and wild-type alleles in mice. Therefore, a transgenic rescue strategy was used to overcome the haploinsufficiency of <italic>Klhl10</italic> and knockout (KO) mice were generated for studying the function of <italic>Klhl10</italic> during spermatogenesis. <italic>Klhl10</italic> KO testes …