Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"transgenic rat"”.
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A Novel Transgenic Rat Model for the Study of Germ Cell Biology
… million publications in scientific journals, the rat is a very important biological model in science. Unfortunately, since the introduction of genetic manipulation technology in the mouse, extension of this technology to the rat has proven to be very difficult. In an attempt to generate a …
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
… MMP-13 and TIMP3, potential MMP-13 substrates in the extracellular matrix and the precise apoptotic signalling involved. Furthermore, we aimed to investigate whether VSMC-specific activation of FOXO3aA3ERTM in mouse affects vascular remodelling during injury and whether this is reliant on …
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Mechanisms of dendritic peptide release
… was performed on hypothalamic slices of the transgenic rat where enhanced green fluorescent protein (eGFP) was tagged to vasopressin. Lysosomes were detected by the lysosome-associated membrane protein LAMP1. Correlation analysis of LAMP1 labelling and VP-eGFP had shown that localisation of …
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Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution
… drugs present at sub-therapeutic concentrations in these tissue compartments that may contribute to the formation of drug resistance and allow systemic viral repopulation. ATP-binding cassette drug efflux transporters i.e., P-glycoprotein and breast cancer resistance protein, have been …
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Beteiligung der Plasmamembran Ca2+-ATPase an Wachstumsregulation und Signaltransduktion im Überexpressionsmodell und im Myokard transgener Ratten
… in der Regulation von Zellparametern wie Proliferation, Differenzierung und Apoptose. Unterstützt wird dies durch die Lokalisation der ATPase in Caveolae, spezifischen Membraninvaginationen, in denen wichtige Zentren der zellulären Signalverarbeitung gesehen werden. Ziel: Mit der vorliegenden …