Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"transgenic overexpression"”.
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
… tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of the BMP antagonist Noggin was targeted to the epidermis and hair follicles (HFs) via Keratin 14 promoter. K14-Noggin mice developed spontaneous HF-derived tumours, which …
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
… tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of the BMP antagonist Noggin was targeted to the epidermis and hair follicles (HFs) via Keratin 14 promoter. K14-Noggin mice developed spontaneous HF-derived tumours, which …
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FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance
… interaction of heterozygous knockout (HET) or transgenic overexpression (TG) of FADS2 in mice fed high fat diets (HFD), as well as the interaction of LA:ALA content in the HFD. Adult male mice with HET (low), wild type (WT; medium), and TG (high) expression of FADS2 were fed HFD (45% w/w) …
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The Role of Arabidopsis thaliana Clade A1 Heat Shock Transcription Factors in Growth and Development
… but have individual and collective functions. Transgenic overexpression of one of its members, HSFA1b, in Arabidopsis was shown to have altered developmental traits as well as increased stress and disease tolerance. In this study, plants overexpressing HSFA1b had smaller rosettes in seedlings …
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Molecular Enhancement of Alpha 7 Integrin to Ameliorate Muscular Dystrophy
… actin in skeletal muscle. It has been shown that transgenic overexpression of the alpha7 integrin chain in mdx/utr (-/-) mice, a model for Duchenne muscular dystrophy, ameliorates dystrophic pathology and prolongs survival. To translate this result into a therapy for patients, myogenic cells from …
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The α7β1 integrin accelerates exercise-induced myogenesis
Muscle-specific transgenic overexpression of the α7β1 integrin can protect against exercise induced-injury and promote the appearance of multipotent mesenchymal-like (Sca-1+CD45-) stem cells in skeletal muscle. PURPOSE: The purpose of this study was to determine if overexpression of the α7β1 …
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Investigation of a role for the α7 integrin as a mechanotransducer of hypertrophic signaling in skeletal muscle
… matrix. Previous research has demonstrated that overexpression of the α7 integrin accelerates the muscle growth response to eccentric exercise compared to wild type controls. PURPOSE: The goal of this project was to elucidate a role for the α7 integrin as a mechanotransducer and intrinsic …
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A biochemical and molecular analysis of functional differences between dystrophin and utrophin
… dystrophin and utrophin. Here, we show that transgenic overexpression of utrophin on the mdx mouse background (Fiona-mdx) is not sufficient to rescue the disorganized microtubule network of the mdx mouse. Thus, we have elucidated a second functional difference between dystrophin and utrophin. …
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Identifizierung und Charakterisierung des krankheitsauslösenden Gens in einem Mausmodell für humane Motoneuronerkrankungen
… Wobbler phenotype could be compensated by the transgenic overexpression of Vps54. This result proved the identity of wr. Possible interaction partners for Vps54 could be identified by the yeast two hybrid system. Many of these proteins function in intracellular vesicle trafficking. Further …
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IMPACT OF HEPATIC APOLIPOPROTEIN A-IV EXPRESSION ON VLDL PARTICLE EXPANSION, TRIGLYCERIDE SECRETION, AND STEATOSIS
… the impact of both apoA-IV deficiency and overexpression on hepatic VLDL-mediated lipid efflux in two different mouse models of hepatic steatosis. Hepatic steatosis induced by either a high fat diet or enhanced de novo lipogenesis, caused by transgenic overexpression of a constitutively …
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Auswirkungen der Überexpression von neuronalem p21ras auf cholinerge Septumneurone der Maus : eine stereologische Studie
Während der Entwicklung ist das Überleben cholinerger septohippokamplar Projektionsneurone von Nervenwachstumsfaktor (NGF) abhängig. Über die intrazelluläre Vermittlung dieses Effektes ist wenig bekannt. p21ras ist ein Schlüsselmolekül in der Signaltransduktion von NGF. Um dessen Funktion in …
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Development of novel strategies to improve skeletal muscle repair and adaptation following eccentric exercise
… We have previously demonstrated that transgenic overexpression of the α7BX2 integrin in skeletal muscle (MCK: α7BX2; α7Tg) enhances muscle repair and the adaptive response following eccentric exercise. Recent studies have provided evidence that mesenchymal stem cells residing in …
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THE ROLE OF ROMA IN MOUSE MAMMARY EPITHELIAL CELLS
… and Twist, in the mammary gland. Additionally, a transgenic mouse model overexpressing a regulator of EMT, Mta3, resulted in hypo-proliferation in the mammary gland, showing a link between EMT regulators and mammary gland development. In a similar pattern to Mta3, mice deficient in Roma (Zfp157), …
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The role of GDNF and its receptor GFRa1 in neuronal development and function
… of postnatal function of those proteins. Transgenic overexpression in animal models on the other hand relates to loss of physiological spatiotemporal regulation of gene expression. These two bottlenecks have hindered the understanding of the role and therapeutic potential of GDNF/GFRa1/RET …
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Losing Connection: Developmental Stress and Synaptic Loss in Caenorhabditis elegans
… in aging animals. We also demonstrated that transgenic overexpression of jmjd-3.1 is sufficient to induce synaptogenesis during normal and stressed conditions with the exception of pathogen exposure. We conclude that in stressed C. elegans there are multiple mechanisms of stress response …