Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"transgenic models"”.
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Adipocytes and Innate Immunity In Systemic Sclerosis
… Six1 in murine dermal adipocytes, and using two transgenic models lacking Six1, we demonstrate that Six1 plays a vital role in the fate of dermal adipocytes in the context of skin fibrosis. In PART II, we discuss a novel finding that a higher circulating neutrophil-to-lymphocyte ratio predicts …
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Distinguishing the Role of the c-myb Proto-Oncogene in Mouse Models of Cardiovascular Disease
… VSMC differentiation. Second, while transgenic models manipulating c-myb have yielded significant insight in regards to homeostasis of the immune system, little is known about a role for c-myb in the regulation of baseline function of the cardiovascular system. While c-myb regulates …
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Immunisierung gegen das Tumorantigen CEA: Vergleichende Untersuchung an Wildtyp- und CEA transgenen Mäusen
Immunization protocols in animal models have shown that the tumor-associated antigen CEA could be a target for active immunization. Since human CEA which does not exist in the rodent genome has been used in these models it is hard to decide whether part of the immune response is directed only to …
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Resolving the Role of POU1F1 in Human Growth Hormone Locus Activation
… for properly regulated hGH-N expression in transgenic mice, but limitations of transgenic models and previous ex vivo systems have prevented the characterization of HSII and many open questions remain for how POU1F1 elements 15 kb upstream regulate hGH-N expression. In the present study, a …
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Role of glucose transporter 1 during pregnancy
… by deleting GLUT1 from the uterus using two transgenic models. The first model consisted of a cross between PRP-Cre mice and mice carrying two copies of the Glut1 floxed gene. The second model was a cross between PR-Cre mice and mice carrying two copies of the Glut1 floxed gene. Our studies …
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Is there a role for NF-κB in the suprachiasmatic circadian clock?
… of feedback loops. Disruption of clock genes in transgenic models leads to dysregulation of the temporal architecture of behaviour and physiology. The master circadian pacemaker is the suprachiasmatic nuclei (SCN) in the anterior hypothalamus. There are circadian oscillators in numerous brain …
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Nrf2 in metabolic related inflammation in the brain
… (<i>hAPP<sub>swe</sub></i>) used in numerous transgenic models. Furthermore, increasing importance has been placed on the suggested link between nutritional status and AD. To assess Nrf2 as a potential target in AD, we examined the effect of metabolic stress, by chronic high fat (HF) feeding …
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Dendritic Cell Regulation of Peripheral Tolerance in Polyclonal T Cell Repertoires
… of antigen leads to peripheral tolerance in transgenic T cells, either by deletion, anergy or the induction of regulatory T cells. We wanted to examine whether delivery of autoantigens to DCs using this approach, could be used to tolerize autoreactive polyclonal T cells, thereby preventing …
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Exploring neuro-immune interactions in neurodegeneration: the role of B lymphocytes in Parkinson’s disease
… distribution of B lymphocytes in alpha synuclein transgenic models of Parkinson’s disease using flow cytometry. Results: B lymphocytes were decreased in PD patients at high risk of progressing to early dementia compared to matched controls. A higher proportion of IL10 producing regulatory B …
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Protein Misfolding and Aggregation in Neurodegeneration: In Vitro And In Vivo Study Cases
… and cognitive deficits in (AD), several transgenic models of AD have been identified. Accumulation of Abeta and fibrillary tangles as well as impairments in working and learning memory are age-related hallmark of AD pathology. To produce a progressive characterization of Abeta and tau …
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Neurogenesis from Neural Stem Cells, Ependymal Cells and Fibroblasts
… brain. In this thesis we have used transgenic models, viral vectors, electroporation-mediated gene delivery and overexpression of transcription factors to demonstrate neurogenesis from neural stem cells, ependymal cells in the lateral ventricular wall and fibroblasts. We show that …
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Functional analysis of insulin-like growth factor binding protein -4 and -6 in transgenic mice
… specific roles in vivo are largely unknown. Transgenic mice overexpressing a particular IGFBP allow us to investigate the specific functions of the corresponding IGFBP in vivo. To this end, IGFBP-4- and IGFBP-6-overexpressing models were established and analyzed in the present study. First, …
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Evaluation neuroprotektiver Strategien am Beispiel ausgewählter neurodegenerativer Erkrankungen: Amyotrophe Lateralsklerose und Alkoholabhängigkeit
Trotz hoher Prävalenzraten und ungünstiger Prognosen liegen für neurodegenerative Erkrankungen aktuell keine vielversprechenden kurativen Behandlungen vor. Auch für die nahe Zukunft erscheint deren Entwicklung als unwahrscheinlich. Aus diesem Grund rücken neuroprotektive Therapieansätze verstärkt …