Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"transforming growth factor-beta1"”.
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Transforming Growth Factor Beta1 und Platelet Derived Growth Factor im Serum und in bronchoalveolärer Lavage bei idioapthischen Lungenfibrosen
… Spiegel der profibrotische Zytokine Transformig Growth Factor ß1 (TGF ß1) und Platelet Derived Growth Factor AB (PDGF-AB) im Serum und in der Bronchoalveolären Lavagenflüssigkeit (BALF) von 87 Patienten mit ILD mittels ELISAs. Dann suchten wir nach Korrelationen zu klinischen Parametern. Bei der …
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Characterization and modeling of cell activation upon TGF-β1 stimulation in a 3-D culture system
… culture model with layered structure and applied transforming growth factor-beta1 (TGF-β1) on the top of the 3-D culture to induce the conversion from normal fibroblasts to myofibroblasts and expression of a marker protein, alpha-smooth muscle actin (α-SMA). The cell response with TGF-β1 …
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Controlled growth factor delivery from biodegradable hydrogel scaffolds for articular cartilage repair
… glycol) fumarate) (OPF) hydrogels as carriers of growth factors for articular cartilage repair has been investigated. In vitro release studies examined release of transforming growth factor-beta1 (TGF-beta1) directly from OPF hydrogels and also from gelatin microparticles encapsulated within these …
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The Role of Astrocyte-Derived Factors in the Regulation of Multidrug Resistance at the Developing Blood-Brain Barrier
… investigated the effects of astrocyte-derived factors on regulating Abcb1/P-gp at the developing BBB. In particular, the studies in this thesis demonstrated the upregulatory effect of transforming growth factor-beta1 (TGF-β1), a growth factor secreted by astrocytes in late gestation, on P-gp …
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Co-culture of hepatocytes with mesenchymal stem cells for cellular therapy in liver disease
… established to investigate the role of paracrine factors in hepatotrophic effect of MSCs co-culture. Hypoxia-preconditioned (HPc) MSCs were co-cultured with hepatocytes to investigate potentiative effect of HPc induction. Intracellular reactive oxygen species (ROS) activity quantitation and …
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Modulation of cell morphology and function using synthetic biodegradable polymers
… a suitable template for directing specific cell growth and tissue formation using cells derived from retinal pigment epithelium (RPE) as an in vitro model. RPE cells were shown to attach to and proliferate on PLGA films during a 7-day culture period. Both polymer composition and initial cell …
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Signal transduction of transforming growth factor-Beta in cytotoxic T cells
Transforming-Growth-Factor-beta1 (TGF-b1) ist ein multifunktionelles Zytokin, welches insbesondere Zellwachstum und Zelldifferenzierung koordiniert. TGF-b ist vor allem dafür bekannt, Zellen des Immunsystems zu beeinflussen. TGF-b steuert zum Beispiel die Differenzierung von T-Zellen und und deren …
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Post-translational processing of proteins implicated in the pathogenesis of Alzheimer's disease.
… approaching the cell membrane, including growth cones of neurones. Therefore, no clear differences in intracellular routing of these proteins were identified, immunocytochemically, in human CNS-type neurones compared with stem cells, which represent non-neuronal cells. This work emphasised …
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Involvement of mitochondrial dysfunction during transforming growth factor β1-induced senescence-like growth arrest of MvlLu cells
… to its high vulnerability to oxidative damage. Transforming growth factor β1 (TGF β1) has well been known to suppress epithelial cell growth and recently been described to be involved in cellular senescence. The purpose of this study is to investigate how TGF β1 could induce senescence in Mv1Lu …
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REGENERATION OF ELECTROSPUN BIORESORBABLE VASCULAR GRAFTS: A PHENOMENON ASSOCIATED WITH VASCULAR GRAFT PROPERTIES AND MACROPHAGE PHENOTYPES (M1/M2)
… Mast cells synthesize several potent angiogenic factors and can also stimulate fibroblasts, endothelial cells and macrophages. An understanding of how they participate in wound healing and angiogenesis is important to further our knowledge about in situ vascular prosthetic regeneration. The …