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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 101 for “"transforming growth factor-beta"”.

  1. The Participation of Transforming Growth Factor Beta in Tumor Immunoevasion

    Fan, Timothy M.University of Illinois at Urbana-Champaign2015

    … in the presence of high concentrations of TGFbeta1, strong costimulatory strength is permissive for the induction of CD8+ T cells possessing suppressor functions. Our studies also demonstrate that the adoptive transfer of peripherally-induced regulatory CD8+ T cells into recipient mice may …

    uiuc Repository record

  2. Signal transduction of transforming growth factor-Beta in cytotoxic T cells

    Feldmann, KristinaUniversität Würzburg

    Transforming-Growth-Factor-beta1 (TGF-b1) ist ein multifunktionelles Zytokin, welches insbesondere Zellwachstum und Zelldifferenzierung koordiniert. TGF-b ist vor allem dafür bekannt, Zellen des Immunsystems zu beeinflussen. TGF-b steuert zum Beispiel die Differenzierung von T-Zellen und und deren …

    wurz-thes Repository record

  3. Transforming Growth Factor-Beta Signalling in Human Cutaneous Squamous Cell Carcinoma

    Rose, Aidan MichaelUniversity of Dundee2015

    … associated with poor survival. <br/><br/>The transforming growth factor-β (TGF-β) signalling pathway is known to play key regulatory roles in skin homeostasis and wound repair. Murine studies indicate that loss of TGF-β signalling is sufficient to drive cSCC, but conclusive evidence for a …

    dundee Repository record

  4. The Role of Transforming Growth Factor-Beta In Alcohol-Induced Cardiac Fibrosis

    Law, Brittany Ann

    … </p> <p> cardiac fibrosis, apoptosis, transforming growth factor beta (TGF-β), and the presence of alpha smooth muscle actin (α-SMA)-positive cells were determined. A compensatory period in mice treated with ethanol occurred early followed by a transition to a dilated phenotype over …

    south-carolina Repository record

  5. Phosphorylation and activation of transforming growth factor beta (TGF-[beta]) receptor kinases

    Chen, FengMassachusetts Institute of Technology1996

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.

    mit Repository record

  6. Transforming growth factor beta 1 : Role in the progression of chronic renal failure.

    Khalil, Mahmoud Salah.Sheffield Hallam University (United Kingdom).2002

    TGF-beta1 plays an important role in the pathogenesis of experimental and clinical glomerulosclerosis and tubufointerstitial fibrosis. Associations have been described between polymorphisms of cytokine and growth factor genes and susceptibility to, or progression of, an increasing number of …

    sheffield-hallam Repository record

  7. The Role of Transforming Growth Factor Beta Signaling in Inflammation-Dependent Colon Cancer

    Ball, CorbieThe University of Arizona.2015

    … (CD) and Ulcerative colitis (UC) are risk factors for colon cancer. TGFβ has been shown to be dysregulated in colon cancer. Bacteria-induced inflammation is necessary for the induction of colon cancer in TGFβ mouse models. However, the mechanism by which TGFβ regulates the inflammatory …

    arizona-thes Repository record

  8. CROSSTALK BETWEEN LYSOPHOSPATIDIC ACID (LPA) AND TRANSFORMING GROWTH FACTOR BETA (TGFβ) IN BREAST AND OVARIAN CANCER CELLS

    Wu, Jinhua2017

    <p>Lysophosphatidic acid (LPA) and transforming growth factor beta (TGFβ) are platelet-derived intercellular mediators of cell proliferation and motility. LPA is a general growth, survival and motility-stimulating factor in mammalian cells. TGFβ prevents proliferation of normal epithelial cells. …

    vcu Repository record

  9. Chronic kidney disease in HIV populations: prevalence, risk factors and role of transforming growth factor beta (TGF-߀1) polymorphisms

    Ekrikpo, Udeme EkpenyongDepartment of Medicine2019

    … to investigate the diagnostic utility of urinary transforming growth factor-beta-1 (TGF-β1) for CKD in the HIV population and determine the association between polymorphisms of TGF-β1 gene and prevalent CKD. Methods: A meta-analysis was performed to document the prevalence of CKD in the global HIV …

    cape-town Repository record

  10. Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells

    Nganwuchu, Chinyere C.University of Bradford2025

    Familial cases of pulmonary arterial hypertension (PAH) are often caused by germline mutations, the most common being a loss of characteristic mutation in the BMPR2 gene, a member of the TGFβ Superfamily. In this study, it was hypothesised that these green tea catechin compounds might inhibit TGFβ …

    bradford Repository record

  11. Investigating the Role of Indoleamine 2,3-Dioxygenase 1 and Transforming Growth Factor Beta 1 in Rebound Immune Suppression Following Chemotherapy in Osteosarcoma

    Passos Barbosa, Matheus MorenoUniversity of Illinois at Urbana-Champaign2023

    Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms

    uiuc Repository record

  12. Einfluss von vascular endothelial growth factor, transforming growth factor-beta-1, Interleukin-6, atrial natriuretic beptide, brain natriuretic peptide und Cortisol auf die Gen-Expression des menschlichen Herzmuskels in vitro

    Fliedner, Anselm

    … untersucht die Effekte von Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor-beta-1(TGF-beta-1), Interleukin-6 (IL-6), Atrial Natriuretic Peptide (ANP), Brain Natriuretic Peptide (BNP) und Cortisol (bzw. Dexamethason) auf das humane Myokard. Um Rückschlüsse auf mögliche …

    freiburg-diss Repository record

  13. Targeting the myofibroblast : new strategies in managing equine corneal fibrosis

    Donnelly, Kevin S.University of Missouri--Columbia2014

    … fibrosis, and is initiated by the presence of transforming growth factor beta. Our results indicate that polyethylenimine nanoparticle therapy is safe and effective and when delivering decorin, a natural antagonist of transforming growth factor beta, fibrosis is significantly inhibited in …

    missouri Repository record

  14. Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins.

    Khaghani, Seyed AliUniversity of Bradford2012

    … change characterized as dedifferentiation. Transforming growth factor-beta (TGF-¿), a cytokine superfamily, regulates cell function, including differentiation and proliferation. The effect of TGF-¿1, 2, 3, and their manipulated forms in biological regulation of primary chondrocyte was …

    bradford Repository record

  15. Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins.

    Khaghani, Seyed A.University of Bradford2012

    … change characterized as dedifferentiation. Transforming growth factor-beta (TGF-¿), a cytokine superfamily, regulates cell function, including differentiation and proliferation. The effect of TGF-¿1, 2, 3, and their manipulated forms in biological regulation of primary chondrocyte was …

    bradford Repository record

  16. Effects of Docosahexaenoic Acid on TGF-ß and SMAD Proteins in COLO205 and WiDr Cells

    Ma, VincentUniversity of Nevada, Reno2011

    Transforming growth factor beta (TGF-ß), a cytokine capable of altering cell growth and differentiation, as well as related transcription factors called SMADs, are among the proteins known to be modified by docosahexaenoic acid (DHA) treatment in T-cells. Unpublished data has indicated that these …

    unr Repository record

  17. Ueber die Funktion von Zinkfinger Proteinen bei der Induktion des Mesoderms in Xenopus laevis

    Duerr, Ulrike2012

    … Invertebraten wird u.a. von Zy tokinen der '' transforming growth factor-beta'' (TGF-beta) Familie reguliert. In der Zielzelle ver mitteln Smad Proteine die Signalweitergabe von der Zellmembran in den Zellkern. Hier kooperieren di e Smad-Proteine mit gewebsspezifischen Transkriptionsfaktoren, …

    goettingen Repository record

  18. Regulation of specific connexins differentially alters gap junction permeability and endothelial cell function

    Elihu, David MoradMassachusetts Institute of Technology2006

    … mediating the expression of vascular regulators transforming growth factor-[Beta][ (TGF-[beta]), prostacyclin, and endothelial nitric oxide synthase (eNOS). siRNA inhibition of connexin 43 in porcine aortic endothelial cells (PAEC) significantly decreased the diffusion distance of Lucifer yellow …

    mit Repository record

  19. Quantitative Single-Cell Imaging Reveals Insulation of Morphogenic Signal Transduction

    Coster, Adam D.2016

    … is present in the integration between Wnt and Transforming Growth Factor Beta (TGFB), which are key developmental pathways. Surprisingly, this insulation extends to the integration of signals within the TGFB superfamily, which are expected to compete for shared components and so interfere with …

    utswmed Repository record

  20. Bone morphogenetic proteins (BMPs): new modulators of the follicle stimulating hormone (FSH) synthesis and release

    Faure, Marie-OdileThe University of Edinburgh2006

    … females, to coordinate the terminal follicular growth, the follicle selection as well as the timing and the number of ovulation. Synthesis and release of both gonadotropins are controlled by hypothalamic gonadotropin releasing hormone (GnRH) and gonadal steroids (progesterone and oestradiol). …

    edinburgh Repository record

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