Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"transforming growth factor β (TGFβ)"”.
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… Nodal ligands, which form a subgroup of the Transforming Growth Factor β (TGFβ) superfamily, regulate the expression several transcription factors implicated in gastrulation. Among these are the paired-like homeodomain transcription factors Goosecoid (Gsc) and Mixl1. At the molecular level, …
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TGFβ signalling in microglia and the impact of microglia-specific Smad4 deletion
The thesis aims to elucidate the role of transforming growth factor-β (TGFβ) signalling in microglia and the regulation of Smad4-mediated microglial functions, and their subsequent impact on central nervous system (CNS) homeostasis, neurodevelopment, and neuroinflammation. The study comprehensively …
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Multiple axes of inter-organ signaling regulate organ scaling
… A central hypothesis predicts that during animal growth, body size is perceived by organs via inter-organ signals, which directs organ growth to match body size. Ligands of the Transforming Growth Factor β (TGFβ) superfamily are prime candidates for mediating this coordination of organ-body size. …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… implicated in the regulation of the canonical transforming growth factor β (TGFβ)-SMAD3 pathway. This study has revealed the significant contribution of the non-canonical pathways including the Hippo pathway to the development of hepatic fibrosis. HSC-specific Sirt6 deficient mice developed …
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The activin a pathway in fetal testis development and dysgenesis in the mouse
… activin A can also function as a paracrine factor in many tissue contexts. As a member of the transforming growth factor β (TGFβ) superfamily, activin A can elicit changes in target cell proliferation, differentiation, and function via the SMAD signaling pathway. Inhibin βA (Inhba), the gene …
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The role of NEDD9 in TGFβ mediated tumour initiating cell dynamics in the Claudin-low breast cancer subtype
… prognosis and response to treatment. Transforming growth factor β (TGFβ) a member of the TGF superfamily of cytokines differentially regulates breast tumour-initiating cells (BTICs). In the claudin-low breast cancer subtype, TGFβ increases the tumour initiating capacity through the …
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Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
… for YAP/TAZ relate to their convergence with growth factor signaling pathways. Based on these previous studies, I hypothesized that YAP/TAZ driven transcription contributes to carcinoma progression, and that cooperation with transforming growth factor β (TGFβ)-induced signals promotes …
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Identification of novel protein kinase regulators of TGFβ signalling
… signalling pathways initiated by members of the transforming growth factor-β (TGFβ) family of cytokines perform critical functions during embryonic development and adult tissue homeostasis. Accordingly, TGFβ family members are involved in the regulation of a diverse array of cellular processes …
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Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function
… <p>SMAD2/3 proteins are downstream mediators of transforming growth factor-β (TGFβ) family signaling, including activins, which regulate critical preadipocyte and mature adipocyte functions. Previous studies have demonstrated that Smad2 global knockout mice exhibit embryonic lethality, whereas …
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Effect of phytoestrogens on breast and prostate cancer cell lines – potential implications for bone metastasis
… effective concentrations are combined. Although, transforming growth factor β (TGFβ), shows antagonist effect on phytoestrogens induced changes when combined with (daidzein and genistein) and blocks any effect of PEs and increase collagen type I gene expression. In MCF7 cells, the non-inhibitory …
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Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… epicardium, coronary vessel formation relies on growth factor as well as extracellular matrix (ECM) influences on cells of the epicardium that regulate proliferation, motility, invasion and differentiation. The Transforming Growth Factor β (TGFβ) family of receptors have been well described in …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
… 21 (NUDT21, which is also known as cleavage factor 25, CFIm25) is a key regulator of alternative polyadenylation (APA). NUDT21 depletion causes 3’UTR shortening via APA leading to enhanced mRNA stability and protein translation. This NUDT21 reduction promotes tumor growth in glioblastoma by …
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Engineered microenvironments for studying liver progenitor differentiation
… as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. However, the complexity of these signaling pathways and their currently undefined interactions with other …