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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 238 for “"transforming growth factor"”.

  1. Characterization Of The Human Transforming Growth Factor-Alpha Promoter.

    Shin, Tae Ho

    uab Repository record

  2. The Participation of Transforming Growth Factor Beta in Tumor Immunoevasion

    Fan, Timothy M.University of Illinois at Urbana-Champaign2015

    In addition to exploring the clinical utility of combination cytokine therapies for the treatment of cancer, our studies also investigate the molecular mechanisms which participate in the generation of peripheral CD8+CD25 + T regulatory cells. Our findings suggest that in the presence of high …

    uiuc Repository record

  3. Signal transduction of transforming growth factor-Beta in cytotoxic T cells

    Feldmann, KristinaUniversität Würzburg

    Transforming-Growth-Factor-beta1 (TGF-b1) ist ein multifunktionelles Zytokin, welches insbesondere Zellwachstum und Zelldifferenzierung koordiniert. TGF-b ist vor allem dafür bekannt, Zellen des Immunsystems zu beeinflussen. TGF-b steuert zum Beispiel die Differenzierung von T-Zellen und und deren …

    wurz-thes Repository record

  4. An Evaluation of Transforming Growth Factor-β Signalling in Adult Glioblastoma

    Willison, AliceUniversity of Dundee2019

    … with the ubiquitous and essential cytokine, transforming growth factor-beta (TGFβ), being a promising therapeutic strategy of unharnessed potential. Here, the role of TGFβ signalling in GBM and the modulation of this signalling pathway as a potential therapeutic target is …

    dundee Repository record

  5. Transforming Growth Factor-Beta Signalling in Human Cutaneous Squamous Cell Carcinoma

    Rose, Aidan MichaelUniversity of Dundee2015

    … associated with poor survival. <br/><br/>The transforming growth factor-β (TGF-β) signalling pathway is known to play key regulatory roles in skin homeostasis and wound repair. Murine studies indicate that loss of TGF-β signalling is sufficient to drive cSCC, but conclusive evidence for a …

    dundee Repository record

  6. The Role of Transforming Growth Factor-Beta In Alcohol-Induced Cardiac Fibrosis

    Law, Brittany Ann

    … </p> <p> cardiac fibrosis, apoptosis, transforming growth factor beta (TGF-β), and the presence of alpha smooth muscle actin (α-SMA)-positive cells were determined. A compensatory period in mice treated with ethanol occurred early followed by a transition to a dilated phenotype over …

    south-carolina Repository record

  7. Phosphorylation and activation of transforming growth factor beta (TGF-[beta]) receptor kinases

    Chen, FengMassachusetts Institute of Technology1996

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.

    mit Repository record

  8. Transforming growth factor beta 1 : Role in the progression of chronic renal failure.

    Khalil, Mahmoud Salah.Sheffield Hallam University (United Kingdom).2002

    … described between polymorphisms of cytokine and growth factor genes and susceptibility to, or progression of, an increasing number of diseases. In this study, single nucleotide polymorphisms (SNPs) in the TGFbeta1 gene were investigated as possible markers for the progression of chronic renal …

    sheffield-hallam Repository record

  9. The Role of Transforming Growth Factor Beta Signaling in Inflammation-Dependent Colon Cancer

    Ball, CorbieThe University of Arizona.2015

    … (CD) and Ulcerative colitis (UC) are risk factors for colon cancer. TGFβ has been shown to be dysregulated in colon cancer. Bacteria-induced inflammation is necessary for the induction of colon cancer in TGFβ mouse models. However, the mechanism by which TGFβ regulates the inflammatory …

    arizona-thes Repository record

  10. ACE inhibiotrs attenuate the expression of renal transforming growth factor-β1 in human

    김, 승정2011

    Doctor

    ajou Repository record

  11. Potential roles for transforming growth factor-B during terminal differentiation of ocular lens cells /

    Richiert, Dawn Marie2015

    … differentiation may be controlled by various factors within the ocular environment. The lens capsule may influence lens fibers, since regions of the capsule differ in components and architecture. TGF-β is known as a regulator of both cell division and differentiation as well as a modulator of …

    wayne-thes Repository record

  12. Immunological Crosstalk between Human Transforming Growth Factor-β1 and the Malaria Vector Anopheles stephensi

    Lieber, Matthew JoshuaVirginia Tech2005

    … of NOS gene expression and catalytic activity is transforming growth factor-β (TGF-β). Moreover, human TGF-β can activate Drosophila melanogaster Smads, the proteins responsible for TGF-β signal transduction. We have determined that following a bloodmeal, active human TGF-β1 (hTGF-β1) persists in …

    vt Repository record

  13. The study of tumor-derived Smad4 mutations in transforming growth factor β (TGF-β) signaling

    Kuang, Chenzhong2005

    This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

    iupui Repository record

  14. Understanding The Role Of Transforming Growth Factor-β Activated Kinase-1 During Inflammation in Diabetic Retinopathy

    Poudel, Umanga2024

    … units through the activation of inflammatory factors and cytokines. Loss in barrier activity in the neurovascular unit leads to leukocyte infiltration leading to the activation of microglia. The role of TAK1 was investigated in murine retinal microglial cultures in vitro by looking into the …

    iupui Repository record

  15. Characterizing the motogenic response of human keratinocytes to epidermal growth factor and transforming growth factor-alpha

    Rodgers, Stephen DMassachusetts Institute of Technology1996

    Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.

    mit Repository record

  16. CROSSTALK BETWEEN LYSOPHOSPATIDIC ACID (LPA) AND TRANSFORMING GROWTH FACTOR BETA (TGFβ) IN BREAST AND OVARIAN CANCER CELLS

    Wu, Jinhua2017

    <p>Lysophosphatidic acid (LPA) and transforming growth factor beta (TGFβ) are platelet-derived intercellular mediators of cell proliferation and motility. LPA is a general growth, survival and motility-stimulating factor in mammalian cells. TGFβ prevents proliferation of normal epithelial cells. …

    vcu Repository record

  17. The Role and Mechanism of The Homeobox Gene Dlx4 In Transforming Growth Factor-B Resistance In Cancer

    Trinh, Bon Q2012

    <p>Transforming growth factor-b (TGF-b) is a cytokine that plays essential roles in regulating embryonic development and tissue homeostasis. In normal cells, TGF-b exerts an anti-proliferative effect. TGF-b inhibits cell growth by controlling a cytostatic program that includes activation of the …

    uthsc Repository record

  18. The Role of Type III Transforming Growth Factor-β Receptor in Regulating ALK1 Signaling and Endothelial Biology

    Hector-Greene, Melissa Erica2017

    <p>The Transforming Growth Factor-β (TGF-β) superfamily of ligands and receptors play critical roles in angiogenesis, evidenced by their essential role in physiologic angiogenesis and their perturbation in pathologic angiogenesis. In development, loss or mutation of Activin receptor-Like Kinase 1 …

    duke Repository record

  19. Involvement of mitochondrial dysfunction during transforming growth factor β1-induced senescence-like growth arrest of MvlLu cells

    윤, 영실2011

    … to its high vulnerability to oxidative damage. Transforming growth factor β1 (TGF β1) has well been known to suppress epithelial cell growth and recently been described to be involved in cellular senescence. The purpose of this study is to investigate how TGF β1 could induce senescence in Mv1Lu …

    ajou Repository record

  20. Transforming Growth Factor Beta1 und Platelet Derived Growth Factor im Serum und in bronchoalveolärer Lavage bei idioapthischen Lungenfibrosen

    Vogel, EvaUniversität Würzburg

    … Spiegel der profibrotische Zytokine Transformig Growth Factor ß1 (TGF ß1) und Platelet Derived Growth Factor AB (PDGF-AB) im Serum und in der Bronchoalveolären Lavagenflüssigkeit (BALF) von 87 Patienten mit ILD mittels ELISAs. Dann suchten wir nach Korrelationen zu klinischen Parametern. Bei der …

    wurz-thes Repository record

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