Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 85 for “"transformed cells"”.
-
DNA synthesis and methylation in normal and transformed cells
… known to affect DNA synthesis in tissue cultured cells, were tested for their ability to alter the methylation status of DNA. The effects of three DNA synthesis inhibitors, viz. hydroxyurea (HU), 1-S-D-arabinofuranosyl cytosine (ara-C) and aphidicolin were examined on a normal embryonic lung …
-
Control of major histocompatibility Class I antigen expression in adenovirus transformed cells.
… MHC class I expression is down-regulated in cells expressing Adenovirus (Ad) 12 E1A compared to cells expressing E1A from Ad2 or Ad5. The possible involvement of these sequences and the factors that bind to them in this down-regulation was investigated using transient expression assays and in …
-
The dissemination of oncogenic RasV12-transformed cells in the adult Drosophila intestine
Dissemination of transformed cells is a key process in metastasis. Despite its importance, how transformed cells disseminate from an intact tissue and enter the circulation is poorly understood. Here, we use a fully developed tissue, Drosophila midgut, and describe the morphologically distinct …
-
Some aspects of the ultrastructure and enzyme cytochemistry of normal and virus-transformed cells
… have been applied to three normal and transformed cell systems in order to relate changes in hydrolytic enzyme activity to changes in ultrastructural organisation occurring when normal cells in vitro are transformed by tumour virus. On transformation changes in cell shape, growth and …
-
Effect of Time and Diet on the Immune Status of Mice Challenged with Herpes-transformed Cells
<p>Human Herpes simplex virus type 2 (HSV 2)-transformed Balb/c mouse cells (H238 cells) are malignant in Balb/c mice. The immune stratus of mice bearing H238 cell-induced tumors was studied and changes in immune response with time and with altered diet of the mice were measured.</p> <p>In the …
-
Studies on Cell Surface Function and Structure in Normal and in Rous Sarcoma Virus Transformed Cells
Made available in DSpace on 2014-12-14T07:14:39Z (GMT). No. of bitstreams: 1 7524315.pdf: 4584155 bytes, checksum: 8455e8d06b00992d004a353e99ad8c13 (MD5) Previous issue date: 1975
-
Expression and regulation of the nuclear transport proteins, Crm1 and Kpnß1, in cervical cancer and transformed cells
Includes abstract. Includes bibliographical references (leaves 204-223).
-
The Effects of Levamisole, CORYNEBACTERIUM PARVUM, and Unblocked Lymphocytes on Mice Injected with Herpes Virus Type 2-transformed Cells
… the immune status of mice injected with HSV-2 transformed cells.</p> <p>Balb/c mice were randomly divided into 6 groups. Group 1 mice were used as negative controls and received no tumor cell injection. All other groups received subcutaneous injections of 1 x 10<sup>6</sup> cells/ mouse. Tumor …
-
The Effect of Dietary Fat Level on Tumor Development and Immunity in BALB/C Mice Fed Casein of Wheat Gluten as Protein and Challenged with Herpes Type 2-transformed Cells
… BALB/c mice injected with herpes simplex Type 2-transformed mouse cells (H238), the effects of a diet which greatly enhanced tumor growth was compared with one which restricted tumor growth. The latter, a low (5%) fat, low protein diet, in which the protein was casein, was also found to produce a …
-
Identification of the Apoptin tumour specific kinase/s
… to induce specific killing targeted at human transformed cells, leaving non-transformed cells unaffected. Investigation has revealed that Apoptin is phosphorylated on a threonine residue in transformed cells, suggesting a role for kinase activation in Apoptin cytotoxicity.<br/>The aim of this …
-
Apoptosis and porphyrin biosynthesis by a photodynamic chemotherapeutic
$\delta$-Aminolevulinic acid (ALA) causes transformed cells to accumulate protoporphyrin IX (Proto). Subsequent exposure to light in vitro causes intracellular Proto to initiate formation of singlet oxygen molecules, leading to self-destruction. This photo-activated destruction by ALA is enhanced …
-
Potassium and Sodium Movements Related to Growth State and Malignant Transformation in Cultured Chicken Embryo Cells
… density-inhibited, and Rous sarcoma virus-transformed (RSV-transformed) chicken embryo fibroblasts and following serum stimulation of quiescent, density-inhibited chicken embryo fibroblasts. Active potassium transport and the associated specific ouabain binding were shown to be dependent on …
-
Effect of Lipid Modification on Transformation - Associated Properties and Viral Membrane Assembly
… of the plasma membrane between normal and transformed cells was different. It was found that the transformed cells had a more rigid plasma membrane, as measured by DPH fluorescence polarization. The increased polarization was correlated with a higher …
-
ΟΙ ΣΥΝΕΠΕΙΕΣ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΗΣ ΠΡΩΤΕΙΝΗΣ Ρ21 ΓΟΝΙΔΙΑΚΟΥ ΠΡΟΙΟΝΤΟΣ ΤΟΥ ΟΓΚΟΓΟΝΙΔΙΟΥ Η-RAS1 ΚΑΤΑ ΤΗΝ ΚΑΡΚΙΝΟΓΕΝΕΣΗ
… MICE CARRYING TUMOURS INDUCED BY MOUSE CELL-LINE TRANSFORMED BY THE HA-MUSV AND THE PRESENCE OF F-MLUV BY ELISA TEST. THE ELAVATED LEVELS OF RAS P21 WAS EXAMINED IN THE SERA OF CANCER PATIENTS ALSO. ONLY IN 3OUT OF 13 CASES REPRESENTING PATIENTS WITH STOMACH ADENOCARCINOMAS WAS RAS P21WAS …
-
A Role for RAS in V-CRK Transformation
… pathways that might be activated in v-Crk transformed cells were investigated by analogy to pathways utilized by v-Src and the activated EGFR, and a search for serine/threonine kinases activated in v-Crk transformed CEF was conducted. Mapk was identified as one kinase, the activity of which …
-
From Mechanisms of Leukaemogenic Dysregulation to New Candidate Therapeutics
… maintenance of a continuous flow of mature blood cells from a reservoir of specialised haematopoietic stem cells requires regulation from an intricate network of regulatory programmes. Gene regulatory networks are well evolved to control multi-lineage commitment and differentiation while …
-
Synthetic Lethality of Cdk Inhibition and Doxorubicin In Triple-Negative Breast Cancer Requires P53 Inactivation
… Therefore, we <strong>hypothesized that TNBC cells are sensitive to cell cycle targeted combination therapy, which leaves non-transformed cells unharmed</strong>. Our findings demonstrate that sequential administration of the pan-CDK inhibitor roscovitine prior to doxorubicin treatment is …
-
THE EFFECTS OF RETINOIC ACID ON CELLULAR TRANSFORMATION AND TUMORIGENESIS INVOLVING CELLS WITH KNOWN ONCOGENES (VITAMIN A, RETINOIDS, RETROVIRUS)
… carcinomas containing a c-ras gene, retrovirally transformed cells were tested for RA sensitivity. Kirsten murine sarcoma, Balb/c murine sarcoma virus, and Simian sarcoma virus transformed NIH/3T3 and NRK cells were used in these studies. In contrast to the human carcinoma cell lines, …
-
NK Cell Function and Tumor Resistance in Mice Transgenic for Antibody to NK Inhibitory Receptors
… the immune system monitors and eliminates transformed cells before their growth. Transformed cells that survive the immune response are escape variants selected by nature as they have developed mutations in immune recognition components. To boost immune response to these tumors, several …
Page 1 of 5