Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"transendothelial migration"”.
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ROLE OF ACID SPHINGOMYELINASE IN ICAM-1/NHE1-DEPENDENT ENDOCYTOSIS: IMPLICATIONS IN LEUKOCYTE TRANSMIGRATION
… 1 (NHE1). ICAM-1 itself plays a key role in transendothelial migration (TEM) of leukocytes, particularly via the transcellular route. This involves endothelial endocytic vesicles that coalesce into transmigration pores, through which leukocytes transmigrate without disrupting EC junctions. …
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Imaging studies of glycan mediated breast cancer epithelial cell-endothelial cell interactions
… namely cancer cell-endothelial cell adhesion and transendothelial migration, using a rocking adhesion assay system in a model of breast cancer metastasis. Three breast cancer epithelial cell lines - MCF 7 and ZR 75 1, derived from breast cancer metastases cells, and BT 747, derived from primary …
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Statin-Mediated Attenuation of Chemokine Expression in Peripheral Nerve Vascular Endothelial Cells
… the course of EAN by inhibiting leukocyte migration. This dissertation project was designed to determine the mechanism(s) by which statins attenuate pathological transendothelial migration. We hypothesized that statins limit transendothelial migration of leukocytes into peripheral nerves by …
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Protein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem Cell Self-Renewal
… BM cells displayed significantly increased transendothelial migration capacity and cobblestone area forming cells (CAFC), consistent with increased Rac1 activation. Furthermore, inhibition of Rac1 abrogated the increased transendothelial migration capacity of PTPRS-/- BM cells, suggesting …
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Mechanisms of inflammation resolution in a murine model of Lyme arthritis
… method to characterize neutrophil reverse transendothelial migration from the inflamed site. Lastly, we demonstrated that sleep fragmentation impairs B. burgdorferi clearance from the joint and prevents efficient mLA resolution. These findings strengthen our understanding of inflammation …
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The multiple migratory mechanisms of systemically infused mesenchymal stem cells to sites of inflammation
… third chapter, we study MSC ability to perform transendothelial migration, a specific step in the process of MSC trafficking, using high resolution confocal and dynamic imaging techniques. We found that MSC transmigration is associated with both leukocyte-like and novel mechanisms, including …
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Therapeutic Application of Carbon Monoxide in Acute Limb Compartment Syndrome
… barrier, apoptosis, leukocyte activation and transendothelial migration in response to CS stimulus. Thus, CORM-3 appears to have an enormous clinical potential; it might be capable of at least prolonging the surgical window, if not significantly reducing the need for fasciotomy
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Role of Rap and Rho GTPases in T-acute lymphoblastic leukaemia cell adhesion and migration
… has often been shown to correlate with the migration and accumulation of T-ALL cells in the tissues. Rap and Rho family GTPases play key roles in T cell adhesion and migration and are often involved in cancer progression. Most of these proteins are post-translationally isoprenylated to …
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Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models
… scaffolds and through mobilization and migration of endogenous MSCs to injury sites. MSC fate and function is determined by microenvironmental cues, specifically dimensionality, topography, and cell-cell interactions. MSC responses of migration and differentiation are the focus of this …
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Expression of leukocyte-endothelial adhesion molecules during acute inflammation in the lung
… endothelium while CD11/CD18 is required for PMN emigration into extravascular tissues. An inducible endothelial ligand for CD18 is intercellular adhesion molecule-1 (ICAM-1). In the pulmonary circulation, PMNs emigrate by either a CD 18-independent or CD 18-dependent mechanism. The objective of …
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Engineered microvasculature platforms to study tumor-host-matrix interactions during metastatic seeding
… tumor cell circulatory transport, arrest, and transendothelial migration. The microdevice features self-organized human microvascular networks through which tumor cells can be perfused and tracked over time via standard confocal microscopy. In addition to improved throughput for parametric …
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In vitro study of cancer cell extravasation in microfluidic platform
… adhesion to the endothelium and subsequent transmigration can be observed. A second model is then introduced to mimic organ-specific extravasation and investigate the preference of certain types of cancer to target specific organs for metastass. The improved model was used to study the …
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Overcoming the biological barriers to intravenous delivery of stem cells and drugs for the treatment of vascular-related diseases
… stem cells consequently exhibited a higher migration ability to ischemic muscle. The strategy of surface tethering was then applied towards protecting stem cells in the oxidative diseased sites, as presented in Chapter 3. The nanoparticles are devised to rapidly discharge antioxidant …