Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"transection injury"”.
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KERATIN BIOMATERIAL SCAFFOLDS FOR PERIPHERAL NERVE REGENERATION
Peripheral nerve injury is a relevant clinical concern. Although surgical management of these injuries has improved over time, the current "gold standard" for nerve transection injury, autograft, has many limitations. Nerve conduits are used as an alternative to autograft surgery but they are …
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Enhancing spinal cord repair with connexin43 antisense oligodeoxynucleotides
Spinal cord injury is comprised of the initial injury and the secondary effects including injury spread, swelling, inflammation, and scarring. Connexin43 (Cx43) gap junctions and hemichannels contribute significantly to spinal cord injury by remaining open in dying cells, spreading toxic substances …
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Exploring SARM1 as a target to delay programmed axon degeneration
… degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There is increasing evidence that this pathway can be activated in human painful neuropathies and preclinical …
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
… axons within the nerve bridge following transection injury. However, this did not affect the number of axons innervating the distal nerve. Moreover, functional recovery was not impacted after a crush injury. Additional studies on axon outgrowth following crush injury, and analysis of …
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The Role of Slit/Robo Signalling in Peripheral Nerve Regeneration
… in axon pathfinding following peripheral nerve transection injury where axons must find their way across the newly-formed nerve bridge. This project aimed to study the expression pattern of Slit and Robo family members in both the intact and injured adult peripheral nervous system to establish a …
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Investigating molecular mechanisms of neuronal regeneration: a microarray approach.
Injury to the peripheral nervous system (PNS) stimulates a finely regulated regenerative response that generally leads to some recovery of function. In contrast, the response to injury in the adult mammalian central nervous system (CNS) is abortive and adult CNS neurons do not normally regenerate. …