Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"transducin"”.
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Mechanism of activation of photoreceptor phosphodiesterase by transducin and by low molecular weight proteins
… are addressed. The first part examines transducin activation of PDE, focusing on the interactions between the gamma subunits and Palphabeta. The second part examines the 17 kDa delta protein believed to regulate bovine PDE. We found that transducin activation of PDE induces heterogeneity …
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Interaction of components I and II with transducin beta gamma subunits and regulation by phosphorylation.
Interaction of components I and II with transducin beta gamma subunits and regulation by phosphorylation.
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Identification of a transducin (beta)-like 3 protein as a potential biomarker of prediabetes from rat urine using proteomics
Obesity is a globally increasing disease particularly in developing countries and among children. It is mainly caused by intake of diets high in fat and the lack of physical activity. Obesity is a risk factor for diseases such as type 11 diabetes, high blood pressure, high cholesterol and certain …
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RATE-LIMITING STEP OF CONE PHOTOTRANSDUCTION RECOVERY AND OGUCHI DISEASE MECHANISMS
… the α subunit of heterotrimeric Gprotein called transducin. Activated transducin relieves inhibitory constraint on cGMP-PDE, leading to rapid hydrolysis of cGMP, closure of cGMP gated cation channels, and membrane hyperpolarization. In order for photoreceptor to be responsive to light again, this …
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Receptor- G Protein Interactions in the Visual System: A Study of Structures and Mechanisms That Couple the Cytoplasmic Surface of Rhodopsin to the Nucleotide-Binding Pocket of Transducin
… rhodopsin and the heterotrimeric G protein transducin (Gt) initiates the vertebrate phototransduction cascade. This interaction also serves as a model system for the study of the molecular basis of related G protein-coupled receptor mediated signal transduction systems. Photoactivated …
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Regulation of rod photoreceptor phosphodiesterase (PDE6) by the glutamic acid -rich protein 2 (GARP2)
… high efficiency of activation by the G-protein, transducin, and the precise control of its inactivation. In addition to binding to transducin during visual excitation, PDE6 is hypothesized to be regulated by other interacting proteins.</p><p>The first aim of this research was to isolate and …
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Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>
… similarities to the GTPase binding protein β-transducin. From structure comparison of the <i>Af</i>Rom2 CNH domain and <i>Af</i>Rho1 to the heterotrimeric transducin complex, I discovered that the top surface of the CNH domain and an α-helix in the switch II region of <i>Af</i>Rho1 may form …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
… inhibition of dynamin. Moreover, we report beta-transducin repeats-containing protein (β-TrCP) as a novel E3- ligase that ubiquitinates p75NTR, which is independent of serine phosphorylation of the p75NTR destruction motif. In contrast to its influence on other substrates, co-expression of β-TrCP …
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Decoding mechanisms of brain tumour initiating cell adaption and tumour growth
… TICs. The human orthologue of CG1671 is Transducin β-like 3 (TBL3). In this work, both genes are referred to as ‘TBL3’ for simplicity. Although the TBL3 nucleolar protein has only been recently implicated in ribosome biogenesis (ribogenesis) of human cells, its potential role(s) in tumour …
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THE ROLE OF R7 REGULATORS OF G PROTEIN SIGNALING IN THE RETINA
… phototransduction by acting as a member of the transducin GAP complex (RGS9-1/Gβ5L/R9AP). The Gβ5L isoform is also only expressed in retinal photoreceptors and acts by stabilizing the GAP complex. The Gβ5S isoform differs from Gβ5L by the absence of exon 1 due to alternative splicing and is …
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Molecular Dissection of Multifunctional Proteins in Rod Outer Segments
… with RGS9-1 and G-beta5, comprises the transducin GTPase activating complex, which catalyzes the rate-limiting step in rod photoresponse recovery. In addition to maximizing the enzymatic activity of the complex, R9AP is responsible for both the post-translational stability and outer …
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Interlocking mechanisms regulating the circadian clock response to DNA damage
… our studies showed that MDM2 collaborates with β-transducin repeat-containing proteins (β-TrCPs), an E3 ligase that targets PER2 for ubiquitylation in a phosphorylation-dependent manner, to control PER2 degradation and thus the length of circadian period. Because the p53:MDM2 pathway plays a …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… by glycogen synthase kinase-3 (GSK-3) causing β-transducin repeat-containing protein (β-TrCP) to ubiquitinate Nrf2 by Skp1-Cul1-F-box (SCF) ubiquitin ligase through the Neh6 domain of Nrf2. Several research groups have shown that induction of ARE-driven genes can be regulated by phosphoinositide …
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AN INVESTIGATION OF THE MECHANISMS OF GROUCHO MEDIATED TRANSCRIPTIONAL REPRESSION
… and includes four orthologs in humans, known as Transducin-like enhancer of split proteins (TLE1-4). This family of co-repressors play crucial roles in many developmental pathways (including Notch, Wingless and BMP/Dpp), and have been implicated in the pathogenesis of some human cancers. Despite …
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Role of Chaperonin CCT in G-protein Biosynthesis
… beta-, and gamma-subunits of the G-protein transducin at the protein level. Later experiments showed that this decrease occurred at the mRNA level as well. While the decrease in Gbeta and Ggamma wasn't surprising, the decrease in Galpha was unexpected since it is not a known substrate of …