Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"transdifferentiation"”.
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Transdifferentiation of fibroblasts to neural stem cells
The developmental process is carefully controlled by transcriptional and epigenetic changes that occur as a zygote transforms into an adult organism. This process can be reversed by the overexpression of transcription factors Oct4, Sox2, Klf4, and c-Myc, which reprogram a differentiated cell!s …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
Myelin sheaths provide trophic support to axons, allow rapid nerve impulse conduction and are critical for neuronal function. Under homeostatic conditions, axons of the central nervous system (CNS) are myelinated by oligodendrocytes. However, in response to demyelination, Schwann cells (SCs), the …
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ENHANCING CARDIAC TRANSDIFFERENTIATION OF FIBROBLASTS USING SINGLE-CELL TRANSCRIPTOMICS ANALYSIS AND HIGH-THROUGHPUT CHEMICAL LIBRARY SCREENING APPOACHES
Cardiac transdifferentiation could potentially be used to treat acute myocardial infarction, but it is hampered by the lack of effective experimental protocols. By performing high-throughput chemical library screening, we serendipitously discovered that dimethyl sulfoxide (DMSO) itself improves the …
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Silencing of endoglin in rat hepatic stellate cells by RNA interference identifies endoglin as an important component of the transdifferentiation process
… the impact and the function of endoglin in the transdifferentiation process of HSC into myofibroblast-like cells (MFB). Transdifferentiation of HSC into MFB plays a crucial role in the wound healing process of the liver and is, thus, linked to the development of fibrosis. Endoglin functions as a …
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The Regulatory Mechanism of Dietary Pattern in TMJ Condyle Growth
Background: The mechanism of chondrocyte transdifferentiation into bone cells during postnatal condylar growth is unknown. Purpose: To quantify the effects of dietary loading on condylar chondrocyte transdifferentiation. Research Design: Chondrocyte tracing was performed in 21 …
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TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
… participates in the control of profibrogenic transdifferentiation to myofibroblast-like cells. Ligation of the common bile duct was used to induce liver fibrosis in rats. Animals received injections of an adenovirus overexpressing Smad7. The effect of Smad7 on TGF-beta signaling and activation …
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Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming
… factors is sufficient to induce the transdifferentiation of lineage-restricted fibroblasts into functional neurons; however, a mechanistic model of the immediate-early events that catalyze this conversion has not been well defined. We utilized a high-efficiency reprogramming system of …
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Elucidating the regulatory mechanisms of pterygium
… and Western blot were utilized to detect cell transdifferentiation. Human angiogenesis protein array was used for investigating angiogenic activities in pterygial fibroblasts. Gene microarray was employed to provide a global profile of gene expression in unstimulated and treated (1ng/ml TGFβ2 …
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Molecular Control of Lens Development in Xenopus Laevis
… lens-forming process termed cornea-lens transdifferentiation. Considering that both lens-forming processes result in the same ultimate outcome, it begs the question: How related are the molecular events involved in the embryonic and regenerative processes? Chapter 2 will examine gene …
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Expression, Reinigung und therapeutischer Einsatz eines löslichen TGF-[beta]-Typ-II-Rezeptors in der experimentell induzierten Leberfibrose
… is as a mastercytocine responsible for the transdifferentiation of hepatic stellate cells to myofiborblasts, the key-event of liverfibrosis. The protein may intercept tgf-beta before binding the hepatic stellate cells. For amplification of the protein COS-7 cells were infected with the …
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Untersuchung von antigenpräsentierenden Funktionen bei kultivierten hepatischen Sternzellen und transdifferenzierenden Myofibroblasten der Ratte
… of HSC is both in vitro, in the course of the transdifferentiation of HSC to myofibroblast (MFB), as well as in vivo investigated. Cultured activated HSC express mRNA for all the process of antigen presentation related genes, such as (RT1B, RT1D) (alpha- and beta-chain) of the MHC II complex, …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… that promotes fibroblast to myofibroblast transdifferentiation. We hypothesized that TGFb induces myofibroblast transdifferentiation via activation of fibroblast-RelA, an event that may precede the development of vascular inflammation and AAA formation. Using primary human fibroblasts, I …
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Defining metabolic zonation as a determinant of hepatocyte plasticity
… that mature hepatocytes have the capacity for transdifferentiation in order to contribute to biliary repair; however, it remains unknown whether all hepatocytes possess this propensity or whether lineage plasticity is zonated within the lobule. This study aimed to investigate whether the …
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Identification and Classification of Novel Gene Products Involved in Development and Regeneration in Xenopus Laevis
A cornea-lens transdifferentiation-specific cDNA library has been used to characterize new molecular events in lens regeneration. Most of these genes are also expressed during lens development, illustrating the similarity between mechanisms of development and regeneration. A subset of genes; whose …
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Epithelial cell plasticity in chronic liver disease (MASLD/NAFLD)
… 2020). A potential mechanism of interest is the transdifferentiation of cholangiocytes into hepatocytes via either direct differentiation or via a progenitor cell population (Michalopoulos & Khan, 2015). However, the reality of this process in a disease context especially in human remains to be …
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Role of Macrophages in Ocular Surface Fibrosis
… and whether macrophages could cause the transdifferentiation of ocular surface fibroblasts into myofibroblasts, thus contributing to oGVHD-associated fibrosis.</p> <p>Bone marrow cells were cultured in M-CSF to obtain M0 macrophages, which were subsequently polarized into M1 and M2 …
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Molecular Profiling: Gene Expression Reveals Discrete Phases of Lens Induction and Development in Xenopus Laevis
… characterize their roles in development and transdifferentiation. The matrix metalloproteinase Xmmp-9 was found to function during migratory and morphogenetic processes during development, and it was found to be upregulated during wound healing. Psf2 codes for a factor which functions during …
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Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores
… pigment cells—leucophores—one of which arises by transdifferentiation of adult melanophores and another of which develops from a yellow–orange xanthophore or xanthophore-like progenitor. Single-cell transcriptomic, mutational, chemical, and ultrastructural analyses of zebrafish leucophores …
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TGF-β Signaltransduktion in der experimentell induzierten Leberfibrose durch die Gallengangsligatur bei der Ratte
… in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-beta effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis are scarce. Methods: Here, liver fibrosis was assessed subsequent to bile duct …
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