Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"transcriptional response"”.
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SPATIOTEMPORAL CONTROL OF THE SALT STRESS INDUCED TRANSCRIPTIONAL RESPONSE IN ARABIDOPSIS
… spatiotemporally under salt stress and how transcriptional regulation occurs. Firstly, I did an analysis on a previously generated spatiotemporal transcriptional map of salt stress in Arabidopsis roots, covering 4 core cell types and 6 time points for salt treatment. Based on this …
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Characterization of a transcriptional response to population density in Bacillus subtilis
… by using extracellular signaling molecules. In response to the accumulation of these signals, changes in gene expression coordinate the switch from unicellular activity to group behavior. In Bacillus subtilis, this shift towards social behavior occurs, in part, through a signaling pathway that …
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Transcriptional response to spatial learning and foraging in honey bees: molecular bases for adult neuroplasticity
An important goal of neuroscience research is to discover molecular processes that enable persistent neuroplasticity in the adult and aging brain. In many species, some types of neuroplasticity typically decrease with age. Honey bees and other social hymenopterans, however, exhibit a reinstatement …
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Transcriptional response of O⁶-methylguanine methyltransferase deficient yeast to methyl-N-nitro-N-nitrosoguanidine (MNNG)
… in protein phosphorylation. In the WT, the response was restricted to a transient repression of fundamental biochemical processes. Interestingly, a gene whose repression is known to mimic apoptosis was found to be repressed in the WT. The overwhelming induction of ribosomal protein synthesis …
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Transcriptional response and DNA adduct analysis of murine liver exposed to aflatoxin B₁ by Jeanette Louise Allen Fiala.
… of neonates caused strong and wide ranging transcriptional responses.
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The Landscape of Host Transcriptional Response Programs Commonly Perturbed by Infectious Pathogens: Towards Host-Oriented Broad-Spectrum Drug
… (a) gene expression data representing host responses upon infection by a pathogen, (b) annotations of genes to pre-defined biological pathways and processes, and (iii) genes that are targets of known drugs. Our methods combine gene set-level enrichment with biclustering. We applied our …
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An Interactive Natural Host Model System for a Swine Alphaherpesvirus: Aujeszky's Disease Virus Cell Interactions in Immortalized Porcine Olfactory Neuroblasts
… conducted studies exerted a highly cell-specific transcriptional response with neuron-specific attributes in the swine neuronal cell line.
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Estrogen Receptor Regulation of Xenopus Laevis Vitellogenin Gene Expression
… Xenopus laevis estrogen receptor mediates the transcriptional response of the vitellogenin gene was investigated. The Xenopus estrogen receptor (XER) cDNA was cloned and sequenced. It could encode a protein of 66 Kd, which is approximately the same size as human and chicken estrogen receptors. …
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Characterisation of the molecular mechanisms of dopaminergic axonal growth and their impairment in Parkinson's disease
… for PD, it is important that the cellular response to GDF5 is unaffected by the disease process. In Chapter 2, we demonstrate that GDF5 signalling is normal in cellular models of PD. Leucine rich repeat kinase (LRRK)2, both wild type and the PD associated G2019S mutant, had no impact on the …
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Chromatin Control of the Antiviral Response to Influenza
… complexes controlling transcription or co-transcriptional processes, thus impacting gene expression. Histone tail modifications are regulated by multiple, often overlapping pathways in the cell, and as such, present an important regulatory "node" through which the cell is able to integrate …
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Transcription and chromatin dynamics in the Notch signalling response
… retaining precision, speed and robustness in the transcriptional response. The primary goal of this PhD has been to gain a better understanding of this process of rapid transcriptional activation in the context of the chromatin environment. To learn about the dynamics of the Notch transcriptional …
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Genetic networks controlled by the bacterial replication initiator and transcription factor DnaA in Bacillus subtilis
… also been implicated in directing part of the transcriptional response to replication stress. Because dnaA is essential, most of DnaA's potential effects on gene expression have been determined through indirect methods, which have implemented perturbations in replication and sequence analyses …
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The splicing inhibitor Isoginkgetin leads to defects in multiple phases of the cell cycle
… checkpoints and p53 is strongly activated in response to transcriptional stresses. Therefore, we determined the effect of p53 and Isoginkgetin treatment on cell cycle progression. Wildtype p53 expressing cells exhibited a remarkable S phase defect while the p53-null subline accumulated with 4C …
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ANALYSIS OF VARIATIONS IN SUSCEPTIBILITY AND TRANSCRIPTOME RESPONSES IN TOMATO TO TWO-SPOTTED SPIDER MITE FEEDING
… and susceptible tomato cultivar transcriptiome responses to mite feeding. Cultivars were screened for mite resistance using a platform developed and presented in this thesis. MicroTom (a brassinosteroid biosynthesis mutant) was found to be resistant to mite feeding, while MicroTom-D (a near …
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Mechanistic Dissection of Tcf7l1-Dependent Enhancer Decommissioning During Exit from Naïve Pluripotency
… regulatory network as well as a redirection of transcriptional response to Wnt/β-catenin signaling. Here, we show that Tcf7l1 functions as a linchpin factor that connects the two outcomes via effects at Tcf7l1-bound cis-regulatory elements in mouse pluripotent stem cells. A combination of gene …
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Computational analysis of genomic data provides insight into cell sensitivity to BCNU-Induced DNA damage
The transcriptional response to DNA damage plays a critical role in cellular responses to exogenous stress, and is a key component of resistance to therapeutics in cancer cells. Understanding the underlying mechanisms, as well as the differences in DNA damage responses, between cell lines can have …
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Computational analysis of genomic data provides insight into cell sensitivity to BCNU-Induced DNA damage
The transcriptional response to DNA damage plays a critical role in cellular responses to exogenous stress, and is a key component of resistance to therapeutics in cancer cells. Understanding the underlying mechanisms, as well as the differences in DNA damage responses, between cell lines can have …
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Mechanisms of Specificity in Neuronal Activity-regulated Gene Transcription
… sought to elucidate how the timing and level of transcriptional responses following neuronal activity can be precisely regulated to form proper neuronal connections. In the first part of this dissertation, I investigated the role of the developmentally regulated GluN3A subunit in NMDAR-induced …
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Understanding the role of the Notch intracellular domain in transcription hub formation
… dependent manner. Despite the complexity of response, the core pathway is simple. Upon ligand binding, the Notch receptor is cleaved and the Notch intracellular domain (NICD) translocates to the nucleus. In Drosophila melanogaster, NICD forms a complex with Suppressor of Hairless (Su(H)) and …
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Estrogen Regulation of Gene Expression and Analysis of the Role of the Coregulator, Repressor of Estrogen Receptor Activity (Rea)
… revealed a greater uterine weight gain in response to estradiol (E2) and a greater stimulation of E2 up-regulated genes and a loss of down regulation in genes normally suppressed by E2 in the uterus. Analysis of the histology of the uterus and mammary gland in REA wild type and heterozygous …
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