Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"transcriptional reprogramming"”.
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Epigenetic determinants of cellular differentiation, transcriptional reprogramming, and human disease
Much of the diversity we observe in cellular and organismal phenotypes can be attributed to epigenetic and genetic variation. DNA provides the instructions for life, while epigenetic modifications regulate which parts of the genetic information contained in DNA can be read out in a given cell and …
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Interactive effects of elevated carbon dioxide concentration with nutrient availability and leaf development on plant carbon metabolism
… (FACE) field experiment; (2) determine the transcriptional reprogramming of leaf respiration in response to growth in elevated [CO2] and variable N supply using Arabidopsis thaliana and a custom built gas exchange system; (3) determine when in leaf development the transcriptional …
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Defining and Targeting Epigenetic Rewiring During Tumor Progression
… recurrent tumors undergo dramatic epigenetic and transcriptional reprogramming, partially through acquisition of an epithelial-to-mesenchymal transition (EMT). EMT promoted epigenetic silencing of tumor suppressor Par-4 through a unique, bivalent histone configuration. This bivalent configuration …
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The role of citrate in plant-pathogen interactions
… that it might act as a metabolic signal for transcriptional reprogramming. In this study, functional enrichment analysis revealed statistically significant enrichment for gene ontology terms associated with defence in both citrate up-regulated and down-regulated gene sets. Furthermore this …
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Computational Identification and Functional Characterisation of Candidate DNA Binding Effectors in <i>Phytophthora</i>
… timecourse experiments has revealed dramatic transcriptional changes as a consequence of infection, suggesting a role for pathogen effectors in transcriptional reprogramming throughout its disease cycle.<br/>We hypothesise that Phytophthora genomes encode effectors that translocate into host …
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Investigating temperature signalling pathways in Arabidopsis thaliana using small molecules
… Arabidopsis thaliana seedlings undergo rapid transcriptional reprogramming of several hundreds of genes that promote stress tolerance. Despite extensive characterisation of the transcriptional responses to these stimuli, however, relatively little is known about the mechanisms by which …
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D14-LIKE: An essential protein for the establishment of arbuscular mycorrhizal symbiosis
… structures in the roots requires their radical reprogramming. This starts during pre-symbiotic communication, where signals are exchanged between the fungus and plant across the rhizosphere. The receptor D14-LIKE emerged as a vital component of this pre-symbiotic communication when it was found …
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Novel Aspects of the Response to Cellular Stress and Intracellular Bacterial Pathogens
… for mRNA splicing. Furthermore, we report global transcriptional reprogramming of a core group of stress-related genes in intestinal epithelial organoids in response to endoplasmic reticulum (ER) stress and nutrient starvation, including transcription factors, chemokines, and genes involved in …
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Plant-parasitic nematodes: from genomics to functional analysis of parasitism genes
… cell wall modification, and even putative host transcriptional reprogramming were identified. In addition, a tool to explore all available nematode EST data is presented in this study. The ‘nematode EST exploration tool’ (NEXT) (http://zion.ugent.be/joachim/next) extends the usefulness by …
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Analysis of gene expression, regulation and function of three symbiotic ABC subfamily-B transporters in Medicago truncatula
… the host and the microbe sets off extensive transcriptional reprogramming of the host developmental programme to accommodate the incoming microbe. Microbial lipochitooligosaccharide molecules trigger a signalling pathway comprising a core set of around seven genes common to both symbioses, …
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Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… by strong driver mutations, extensive epigenetic reprogramming, and a dense tumour microenvironment (TME). A defining feature of the PDAC TME is its fibrotic stroma, which is largely composed of cancer-associated fibroblasts (CAFs). Distinct populations of CAFs, including inflammatory CAFs (iCAFs) …
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Computational and experimental detection of uncoupling between transcriptome and translatome changes of gene expression
… in total mRNA levels, for the presence of post-transcriptional controls which influence the fate of cytoplasmic mRNAs and affect their translational fitness. Nevertheless, the extent of this phenomenon and the rules, if any, governing it are still generally unknown. To address this issue we took …
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Analysis of Medicago truncatula transcription factors involved in the arbuscular mycorrhizal symbiosis
For the first time the transcriptional reprogramming of distinct root cortex cells during the arbuscular mycorrhizal (AM) symbiosis was investigated by combining Laser Capture Mirodissection and Affymetrix GeneChip® Medicago genome array hybridization. The establishment of cryosections facilitated …
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The role of transcription factors in somatic cell nuclear reprogramming by eggs and oocytes
Somatic cell nuclear reprogramming (SCNR) by eggs is a way to forcibly transform the nuclei of terminally differentiated somatic cells to an embryonic state and gain totipotency (Gurdon et al., 1958). Additionally, induced pluripotency is applied to transform identities of somatic cells to induced …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
… TDLN-LECs prior to metastasis and demonstrated transcriptional reprogramming of immune-associated pathways in LECs isolated from early TDLNs. This was accompanied by differentially localized migratory DCs, clustered at lymphatic subcapsular sinuses. In vitro using co-culture assays revealed …
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lncRNA RPPH1 in melanoma: novel functions as cargo of tumor-derived Extracellular Vesicles
… that this EV-mediated signalling drives the transcriptional reprogramming of macrophages toward a tumor-supportive, pro-inflammatory phenotype, typical of tumor-associated macrophages (TAMs). Notably, this response appears to be primarily confined to a macrophage subpopulation inherently …
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Phosphate homeostasis and posttranscriptional gene regulation during arbuscular mycorrhizal symbiosis in Medicago truncatula
… was applied to investigate miRNA-mediated posttranscriptional gene regulation in M. truncatula mycorrhizal roots. Degradome analysis revealed that 185 transcripts were cleaved by miRNAs, of which the majority encoded transcription factors and disease resistance genes, suggesting a tight control …
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Investigating The Ecology and Evolution of Normal Breast Tissues and Breast Cancer With Single Cell Genomics
… in human breast tissues, with different transcriptional programs in the stromal, epithelial, and immune components, however, it remains unclear how their reprogramming and interplay leads to the progression of invasive phenotypes such as Triple- Negative Breast cancer (TNBC). To do define …
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Biochemical Studies of the ER Resident Kinase PERK and Implications for Local Translational Control
… couple ER stress to translational repression and transcriptional reprogramming through phosphorylation of eIF2α. This is achieved through the recruitment of eIF2α by a unique cytoplasmic loop in PERK’s kinase domain. PERK signalling has been shown to play an important role in disease pathology …
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Myc and Cyclin T1 co-expression as a therapeutic strategy for cardiac repair following myocardial infarction
… and MI-injured adult whole hearts confirmed the transcriptional reprogramming of cardiomyocytes and identified a population of proliferative cardiomyocytes as well as changes to cell-cell interactions in the cardiac niche. Cre mRNA localised transient activation of MycER leads to over 13% …
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