Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"transcriptional repressor"”.
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Creation and characterization of mice with a mutation disrupting binding of a transcriptional repressor of insulin-like growth factor 2
… intron 3 of IGF2 disrupts a binding site for the transcriptional repressor ZBED6 leading to increased expression of IGF2. The SNP prevents binding of ZBED6 increasing IGF2 expression prenatally as well as postnatally compared with their wild type counterparts. Pigs with this mutation have a 10 % …
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Characterization of mice with mutations disrupting binding of a transcriptional repressor of insulin-like growth factor 2 and loss-of-function mutation of myostatin
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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MeCP2 and the Epigenetic Regulation of Excitatory Synaptic Transmission
… transcription. Mutations in one such gene, the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2), lead to a form of mental retardation called Rett Syndrome (RTT). Though the MeCP2 protein is expressed ubiquitously, symptoms of RTT patients are primarily neurological, which include …
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METAL TRAFFICKING DURING LIMITATION AND EXCESS IN BACILLUS SUBTILIS
… of the concentrations of these metals, transcriptional regulators control gene expression to combat limitation and excess. Genes involved in responding to zinc excess are under the transcriptional control of CzrA, while genes involved in responding to zinc limitation are under the …
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Blimp-1 Regulates Terminal Differentiation of T Cells
The transcriptional repressor-Blimp-1 terminates differentiation of B lymphocytes as well as myeloid cells. Our data show that Blimp-1 is highly expressed in freshly isolated murine primary T lymphocytes, particularly its minor splice variant. Ectopic expression of Blimp-1 by retroviral …
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Prdm13, a Direct Downstream Target of Ptf1a, Regulates the Balance of Gabaergic Neurons versus Glutamatergic Neurons in the Dorsal Spinal Cord
… in these cells. Given that Ptf1a acts as a transcriptional activator, I hypothesized that Ptf1a induces a transcriptional repressor as one of its downstream targets to mediate the suppression of glutamatergic lineage genes. A chromatin-remodeling transcription factor, Prdm13 (PRDI-BF1 and …
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Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
The transcriptional repressor BCL6 has been shown to be essential for the differentiation of germinal center (GC) B cells and follicular T helper (TFH) cells. The interaction of TFH and GC B cells is necessary for the development of high affinity antibodies specific for an invading pathogen. …
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Molecular analysis of the role of E2F proteins in the pRB pathway
… of these mutations may be mediated at the transcriptional level by E2F. E2F is also regulated by cell cycle-dependent interactions with the pRB-related proteins p107 and p130. Unlike pRB, mutations in p107 or p130 are not associated with cancer. The different properties of the pRB family …
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Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1
… process are NRSF/REST and NeuroD1. NRSF/REST, a transcriptional repressor that binds a specific NRSE site and recruits corepressors and chromatin remodeling machinery to repress its target genes, is critical for maintenance of the neural stem cell pool and for proper pacing of neuronal …
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Characterization of two prevalent yet distinct conjugation systems among lactococci
… of many conjugation-associated genes including a transcriptional repressor of this system. Furthermore, certain non-conjugative plasmids were observed to co-mobilise together with the conjugative plasmid. Chapter III details the mutational and functional analysis of the pUC11B conjugation gene …
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Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1
… region of the brain Here, FoxG1 acts as a transcriptional repressor and maintains the population of cortical progenitor cells by promoting their proliferation and inhibiting differrentiation. Vertebrate FoxG1 orthologs have highly conserved DNA-binding and corbosy-terminal domains that have …
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Analysis of the hex regulon in Pseudomonas aeruginosa
… intermediates. The HexR protein is a negative transcriptional repressor and the Crc protein participates in regulation of these genes and has been shown to be necessary for biofilm formation. The main objective of this study was to analyze control of these genes in different growth mediums and …
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Development of a Burkitt Lymphoma cell line with inducible expression of activated B-cell factor-1
… with another bHLH protein E4 7 to form a transcriptional repressor ofE2A, which is a gene essential to the proper development of B- and T -cells. In an effort to study genes in B-cells regulated by ABF- 1, I have attempted to construct a Burkitt Lymphoma cell line allowing tetracycline …
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Receptor-Mediated Hypertrophic Signaling Via Protein Kinase D and Histone Deacetylase 5 in Adult Myocytes
… in regulation of HDAC5 translocation. HDAC5 is a transcriptional repressor whose dynamic shuttling between the nucleus and the cytosol determines the outcome of transcriptional control for MEF2-dependent genes. I use a combination of biochemical approach with fluorescence imaging techniques to …
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The transcriptional programme of natural killer (NK) cell functional maturation and maintenance
… in tissues are incompletely elucidated. The transcriptional repressor BACH2 plays a critical role within the adaptive immune system but its function within innate lymphocytes has been unclear. The studies presented here show that BACH2 acts as an intrinsic negative regulator of NK cell …
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Regulation of DnaA as a transcription factor by modulation of cooperative binding, and by arrA, an antisense RNA
… in B. subtilis affect its activity as a transcriptional repressor. I found that forms of DnaA that are inhibited for replication initiation are still active transcriptional repressors. This interesting finding raises the possibility that some DnaA targets are regulated in a cell-cycle …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… level, Gsc has been described to function as a transcriptional repressor by directly binding to paired homedomain binding sites on target promoters. Here, I describe a novel mechanism of transcriptional repression by Gsc. Using a molecular and embryological approach, I demonstrate that the …
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Genetic and Biochemical Studies on Protein Phosphorylation in the Circadian Clock of Drosophila Melanogaster
… has led to a paradigm of multiple interlocked transcriptional/translational feedback loops as the basis for molecular circadian oscillators in all studied model systems. Protein phosphorylation plays an essential role, regulating the stability, activity and subcellular localization of proteins …
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LDB-1 AND SWI/SNF CHROMATIN REMODELING COMPLEX PARTICIPATE IN THE TRANSCRIPTIONAL ACTIVATION BY C. ELEGANS BLIMP1/PRDM1
… the human zinc finger and SET domain-containing transcriptional repressor BLIMP1/PRDM1. BLIMP1/PRDM1 and its orthologs are well studied as transcriptional repressors in many species including humans and mice. Interestingly, we found that in C. elegans, BLMP-1 acts as a direct transcriptional …
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Coordinate regulation of Vegf signalling genes by the proline rich homeodomain protein
PRH is a transcriptional repressor that regulates development of the haematopoietic and vascular systems. VEGF is a mitogen that stimulates cell survival via cell surface receptors including VEGFR1 and VEGFR2. This thesis identifies Vegf, Vegfr1, and Vegfr2 as bona fide PRH target genes and shows …
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