Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 162 for “"transcriptional regulator"”.
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The Functional Characterization of the LysR-Type Transcriptional Regulator QseD and the SorC-Type Transcriptional Regulator LsrR in Enterohemorrhagic Escherichia coli
… interpretation and integration of these multiple regulatory signaling networks that often involve intracellular regulatory proteins, such as the lysine regulator (LysR) type transcriptional (LTTR) family member QseA, EHEC is able to coordinate the expression of its multiple virulence factors [4]. …
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Computational and Experimental Investigation of Allosteric Communication in the Transcriptional Regulator NikR
… in <italic>Escherichia coli</italic> through transcriptional repression of the NikABCDE nickel permease. NikR is a homotetramer and each chain contains both a DNA binding ribbon-helix-helix: RHH) domain and a Ni<super>2+</super> binding regulatory ACT: <underline>a</underline>spartokinase, …
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Structural basis for the function of the transcriptional regulator KstR from Mycobacterium tuberculosis
… processes for the phagosome-dwelling Mtb. The transcriptional regulator KstR, which controls a large cohort of genes taking part in the cholesterol degradation pathway, is a potential drug target in Mtb. In this study, KstR has been biochemically and structurally characterised as a basis for …
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Investigating the role of the post-transcriptional regulator protein ZFP36L1 in B-cell functions
… the function of ZFP36L1 and its role in post-transcriptional regulation in B-cell development is extremely limited. The primary aim of this project was to investigate role of ZFP36L1 in regulating B-cell development, in particular late B-cell development (plasma-cell differentiation). BCL-1 …
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Pleiotropic regulatory function of the lysr family transcriptional regulator cpsy during streptococcus iniae systemic infection
… of the <i>Streptococcus iniae</i> LysR family regulator CpsY have been shown to regulate methionine biosynthesis and uptake pathways, but appear to influence expression of several virulence genes as well. A <i>S. iniae</i> mutant with an in-frame deletion of cpsY is highly attenuated in a …
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Determination and Dissection of DNA-binding Specificity for the Thermus thermophilus HB8 Transcriptional Regulator TTHB099
… TTHB099 does not have a simple regulatory mechanism. However, we hypothesize that TTHB099 can be a dual-regulator similar to CRP<sub>Ec</sub>.</p>
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Selective Muscle Degeneration in a Drosophila Model of Cachexia; A Role for the Transcriptional Regulator cabut
… muscle wasting to elucidate a novel role of the transcriptional regulator, <em>cabut</em> (<em>cbt</em>), in selective degeneration of flight muscles over jump muscles. We report that <em>cbt</em> impairs mitochondrial function and expends vital glycogen stores from the flight muscles. Our …
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Discovery of a DNA-binding Consensus and Potential Genomic Regulatory Binding Sites for the Thermus thermophilus HB8 Transcriptional Regulator TTHA1359
… which renders gaps in the understanding of the regulatory networks and systems biology of many organisms. Cyclic-AMP receptor protein (CRP) regulators and fumarate and nitrate reduction regulator (FNR) proteins compose the CRP/FNR superfamily of TFs, a diverse subgroup of TFs in bacteria which …
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Characterisation of pleiotropic regulators of gas vesicle biogenesis, antibiotic production, motility and virulence in Serratia sp. ATCC 39006
… gvrA-gvrC operon is composed largely of regulatory genes. Other genetic regulators of GV biogenesis have been previously described which include the post-transcriptional regulator RsmA, the ribose operon repressor RbsR, the DeoR-family transcriptional regulator FloR, the sigma factor σ …
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Regulation of virulence and antimicrobial peptide resistance in Pseudomonas aeruginosa
… demonstrated here that the psrA gene, encoding a transcriptional regulator, was up-regulated in response to sub-inhibitory concentrations of antimicrobial peptides. Compared to wild-type and the complemented mutant, a P. aeruginosa PAO1 psrA
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Iron and Manganese Homeostasis in Marine Bacteria
… genes was unaffected in growth. The Fe‐specific regulatory network of R. pomeroyi was found to involve the Irr transcriptional regulator, which controlled the expression of several genes. Microarrays revealed many other genes whose expression was enhanced or diminished in Fe‐replete conditions, …
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Investigating the role of ephrins and their receptors in mouse folliculogenesis and ovulation
… the mouse genomic region upstream of Epha5 is transcriptionally activated by cAMP in a protein kinase A-dependent manner. Transcriptional activation of Efna5, Epha3, Epha5, Epha8, and Ephb2 is reduced in GCs of eCG-treated Esr2-/- females, which exhibit impaired cAMP production. These results …
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From detection of proteasomal degradation to targeted control of protein depletion
… that translates proteasomal degradation of a transcriptional regulator engineered to function as a UPS substrate into increase in expression of a fluorescent reporter (GFP), thereby linking enhancement of UPS activity to an easily detectable output. I demonstrate that this genetic inverter …
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Novel pleiotropic regulators of flotation, secondary metabolite production, and virulence in Serratia sp. ATCC 39006
… of GVs is a complex process with a range of regulatory inputs. GVs are expressed from a cluster of 19 genes arranged in two contiguous operons, gvpA1-gvpY and gvrA-gvrC. Prior to this study, three regulators encoded within the GV cluster, which are essential for GV production, had been …
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Transcriptional Regulation of NLRC4 Inflammasome by IRF8
… (BMDMs) is greatly dependent on interferon regulatory factor 8 (IRF8). NLRC4-mediated caspase-1 activation and subsequent production of the inflammasome-dependent cytokines IL-1β and IL-18 and cell death were impaired in IRF8-deficient cells. IRF8 mediated the transcription of genes encoding …
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Biosensor-based strategies for improving pathway production in Escherichia coli
… for myo-inositol (MI) was developed using the transcriptional regulator IpsA from the organism Corynebacterium glutamicum. A hybrid promoter was designed to enable function in the desired host organism E. coli.
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The Influence of The Pep-Pts and Other Metabolic Systems On The Master Virulence Regulator Atxa and to xin Gene Expression In Bacillus Anthracis
<p>AtxA, the master virulence gene regulator in <em>Bacillus anthracis,</em> is a PRD-containing virulence regulator (PCVR) as indicated by the crystal structure, post-translational modifications, and activity of the protein. PCVRs are transcriptional regulators, named for the regulatory domains …
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Small-molecule inhibition of general transcriptional regulators in cancer
… deregulated in cancer, but targeting of transcriptional processes for cancer therapy has thus far been limited to nuclear receptors. Recent studies, however, have suggested that inhibitors of various general transcriptional regulators can be used in cancer therapy because expression of …
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Regulation of Dkk1, an Inhibitor of the Wnt Signaling Pathway, by DAX-1 in Mouse Embryonic Stem Cells
… our hypothesis that DAX-1 acts as a negative transcriptional regulator of Dkk1.</p>
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Characterization of transcripts expressed from the Meis2 locus in the Natal Long-fingered bat (Miniopterus natalensis)
… insertion site 2 (Meis2) gene is an important transcriptional regulator involved in the pattering of the limb during vertebrate development. In the forelimbs (wings) of bats the expression Meis2 was shown to be differentially expressed when compared to mice forelimbs. Meis2 was found to be …
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