Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"transcriptional programs"”.
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HISTONE LYSINE METHYLTRANSFERASE NSD3 GOVERNS TRANSCRIPTIONAL PROGRAMS THAT DRIVE PANCREATIC NEUROENDOCRINE TUMORS (PANNETS)
… that H3K36 methylation by NSD3 functions as a transcriptional activator accelerating tumorigenesis in PanNETs. Additionally, we established a novel genetically engineered mouse model (GEMM) for PanNETs focused on the top inactivating mutations observed in human disease. Lastly, we have …
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Hdac3 is a Critical Regulator of Neural Crest Progenitor Cell Biology
… of multiple progenitor cell pools. Specific transcriptional programs regulate the specification, expansion, migration and eventual differentiation of these progenitor cell populations, and tight control of these programs is essential for normal development to occur. Class I histone …
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Intrinsic Specificity of Binding and Regulatory Function of Class II bHLH Transcription Factors
… provide a mechanism to select tissue-specific programs of gene expression from the shared genome. ASCL1, ASCL2, and MYOD are class II basic Helix-Loop-Helix (bHLH) transcription factors which play crucial roles in lineage specification in the developing embryo. In vivo, these factors bind to …
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ADAP1 Promotes Latent HIV-1 Reactivation by Tuning the KRAS-ERK-AP-1 Signaling-Transcriptional Axis
Immune stimulation fuels cell signaling-transcriptional programs that induce biological responses to eliminate virus-infected cells. Yet, retroviruses that integrate into host cell chromatin, such as HIV-1, co-opt these programs to switch between latent and reactivated states. However, many …
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Exploring the global gene expression programs and regulation in the response of quiescent human fibroblasts to distinct proliferative stimuli
… it is not known to what extent such complex transcriptional events are specific to a given cell type and signal, and to what extent these changes are innate programmed responses that are activated in a range of related cell types in response to a variety of stimuli. We have profiled the …
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Deconvolution of Leukemic Evolution Through Initiation, Progression and Relapse
… assay, we uncovered the importance of novel transcriptional programs, including induced stem cell transcriptional programs, in leukemogenic transformation. Recent evidence has shown that in the majority of B-ALL patients, relapse arises from a minor ancestral clone present in the diagnosis …
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Methods to interrogate cells and their interactions with single-cell resolution
… resolution, critical for determining what transcriptional programs arise and in which cells with what other programs.
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A novel high-throughput in-cell Western assay for the quantitative measurement of signaling dynamics in DNA damage signaling networks : cell decision processes in response to DNA double strand breaks
… arrest, initiation of DNA repair, activation of transcriptional programs, and either apoptosis, necrosis or cell senescence. The mechanisms by which cells make these decisions, and how cell fate depends upon variables such as DNA damage type and dose, and other environmental factors, is unknown. …
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PHF6 modulates the chromatin landscape in B-cell leukemia
… via alteration of the chromatin landscape at the transcriptional start sites of B- and T-cell specific factors. Additionally, Phf6KO cells show significant down-regulation of genes involved in the development and function of normal B-cells, up-regulation of genes involved in T-cell signaling, and …
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Stochastic Activation of Enhancers in the Innate Immune Response by the Histone Demethylase JMJD2D
… processes involving DNA. In particular, transcriptional activation depends on the interplay of dozens of chromatin modifiers to establish an epigenetic landscape permissive of gene transcription. Among the most dynamic histone modifications are the acetylation and methylation at histone 3 …
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EPIGENETIC REGULATION IN AN IPSC-NEURON MODEL OF FAMILIAL ALZHEIMER’S DISEASE
… modifications may lead to the expression of transcriptional programs that may play a role in disease genesis or the worsening of disease pathology. One such histone modification, acetylation of histone H3 lysine residue 27 (H3K27ac), is primarily localized to genomic enhancer regions and …
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Discovery and characterization of a small molecule that modulates c-Myc mediated transcription via max homodimer stabilization
… in regulating normal cellular processes, but its transcriptional activity is deregulated in a majority of human cancers. Myc transcriptional activity is dependent on dimerization with its obligate partner Max, another bHLHLZ transcription factor. Max also forms homodimers as well as heterodimers …
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Strain-resolved transcriptomics: exploring functional heterogeneity of the gut microbiota in health and disease
… metatranscriptomics framework to investigate how transcriptional activity varies across bacterial lineages and relates to IBD pathogenesis. Using paired metagenomics and metatranscriptomics data from 1,067 fecal samples (103 IBD and 335 non-IBD patients), we first constructed phylogenetic trees …
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DNA methylation in early mammalian development
… phenotypes. This is the result of different transcriptional programs, which are partly controlled by epigenetic modifications, including DNA methylation. In this thesis, I analyze genome-scale DNA methylation profiles across pre-implantation development to identify the targets and …
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PU.1-ACTIVATED GENOMIC REGIONS DEFINE LOW-RISK MDS SUBSETS CHARACTERIZED BY IMMUNE DYSREGULATION AND DISEASE PROGRESSION
… active genomic regulatory regions and their transcriptional impact through H3K27ac ChIP-seq and RNA-seq analysis on CD34+ bone marrow progenitors cells isolated from a prospective cohort of 357 patients. Our analysis revealed distinct patterns of genomic region activation and transcriptional …
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Genomic Evolution of Chemoresistance In Triple-Negative Breast Cancer Delineated By Single Cell Sequencing
… subclones with genomic mutations and transcriptional programs that confer resistance to chemotherapy (adaptive resistance) or by the spontaneous induction of new mutations and expression changes that confer a resistant phenotype (acquired resistance). To investigate this question we …
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Chromatin Accessibility Dynamics Underlying Development and Disease
… with RNA-seq assays to identify concurrent transcriptional changes. By mapping the changes to these genome-wide signals we defined the contribution of local chromatin structure to the transcriptional programs underlying these processes, and improved our understanding of their relation to …
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Normal cell signals in human cancer transcriptomes
… cells arise from normal cells, and may retain transcriptional patterns present in the cell of origin. Recent advances in single-cell transcriptomics have allowed us to profile both normal and cancer cells at a single cell resolution, enabling direct comparisons between the two. Such comparisons …
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Roles of Neurogenin and Geminin in Vertebrate Neurogensis
… their target genes. Here, we identified direct transcriptional targets of the bHLH transcription factor Neurogenin. We found that Neurogenin regulates neurogenesis by activating transcription factors, cell signaling components, and genes regulating cytoskeleton rearrangement and cell migration. …
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Generative modeling of the tumor microenvironment : deconvolution, completion, and integration
… latent cell composition and within-cell-type transcriptional variation, enabling joint inference of cell-type proportions, tissue organization, and spatial transcriptional programs. To address incompleteness in biological data, we develop Multi-Channel Diffusion (MCD) and its extension …
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