Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"transcriptional profiling"”.
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Transcriptional Profiling of Early Cardiac Development
… heart. The second study focused on defining the transcriptional network of a key cardiac regulator, Nkx2.5. I identified transcripts misexpressed during the early development of Nkx2.5 null embryos, including the Nkx2.5 transcriptional targets ETSrelated transcription factor 71 and vascular cell …
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Transcriptional profiling of Drosophila larval ventral nervous system hemilineages
… While A neurons display greater overall transcriptional diversity than B neurons, sibling hemilineages share very similar expression profiles. Comparing the gene expression between immature and mature larval neurons revealed that mature neurons express many genes not expressed in immature …
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Transcriptional profiling and flux measurements of polyhydroxybutyrate production in Synechocystis
(cont.) to determine the CO₂ uptake rates and PHB production rates of strains engineered for enhanced CO₂ fixation and PHB production respectively.
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Comprehensive single-cell transcriptional profiling of the regenerative planarian Schmidtea mediterranea
Animals can contain hundreds of cell types, each of which has a distinct morphology and function. The transcriptome of a cell dictates this unique cell biology. Recent approaches for high throughput single-cell RNA sequencing have made it possible to generate transcriptomes easily and affordably …
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Hypothalamic Transcriptional Profiling and Quantitative Proteomics of Mice under 24-Hour Fasting
Energy balance includes energy intake and energy expenditure. Either excessive food intake or insufficient physical activity will increase the body mass and cause obesity, a worldwide health problem. In the US, more than two-thirds of people are obesity or overweight. Conversely, it is well …
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Transcriptional profiling of rat primary hepatocytes cultured in a 3D microfabricated liver reactor
Thesis (M.Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2003.
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Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling
Fractionated whole brain irradiation (fWBI), as used for the treatment of intracranial neoplasia, results in progressive cognitive impairment, and cerebrovascular and white matter injury. Although the clinical progression and morphology of late-delayed radiation-induced brain injury (RIBI) are well …
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Development, characterization and transcriptional profiling of a mouse model of fatal infectious diarrhea and colitis
Citrobacter rodentium is a naturally occurring murine bacterial pathogen which is used to model human diarrheagenic E. coli (EPEC and EHEC) infections in mice. C. rodentium causes colonic hyperplasia and a variable degree of colitis and mortality in the majority of inbred and outbred lines of mice. …
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Transcriptional profiling of potential regulatory factors modulating defense mechanisms in soybean during Phytophthora sojae infection
… pathosystem. The approach was to use global transcriptional profiling based on microarray technology to identify genes that were differentially expressed in four cultivars of soybeans with varying levels of quantitative resistance at different time points during infection by P. sojae. Our …
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A dynamic transcriptome technique for transcriptional profiling and gene regulatory network involving the helicase antigen (HAGE)
… an immuno-compromised murine model. Expression profiling analysis of data gained from using the Genechip oligonucleotide microarray platform found significant changes to genes linked not only with proliferation but other cell processes altered during tumorigenesis. Confirmation using real-time …
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High Resolution Transcriptional Profiling and Characterization of Cellular Inclusions in Arabidopsis thaliana Roots Grown in Low Sulfur Conditions
<p>Environmental stress affects plant development and productivity. Sulfur deficiency is a key nutrient deficiency that adversely affects crop yield. The model plant Arabidopsis thaliana has played an informative role in deciphering the mechanisms involved in sulfur assimilation, as well as, the …
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NOVEL INSIGHTS ON ALLAN-HERNDON-DUDLEY SYNDROME: TRANSCRIPTIONAL PROFILING AND FUNCTIONAL CHARACTERIZATION OF THREE GENETIC VARIANTS IN SLC16A2 GENE
Allan-Herndon-Dudley Syndrome (AHDS) is a rare genetic X-linked pediatric disorder, affecting essentially males, with intellectual and motor development impairment. It is caused by mutations in the SLC16A2 gene, which encodes for MCT8, a transporter responsible for thyroid hormone (TH) transport …
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Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development
Induction of tumor differentiation through manipulation of regulatory genes is a relatively unexplored area of cancer therapy, however, it might suggest and additional approach for tumour-specific treatment. Therefore, in view of this idea, the present study hypothesized that neuroblastomas (NBs) …
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High-Throughput Single-Cell Functional and Molecular Profiling of Immune Cells in Cancer Immunotherapy
… interactions, and microfluidic qPCR for transcriptional profiling. Analysis of thousands of single-cell interactions for over 5 hours revealed that the integrated behavior of polyfunctional T cells that kill and secrete IFN-γ was similar to those without IFN-γ secretion, suggesting …
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Molecular characterization of T cells across disease states in the central nervous system
… functional approaches, including ultra low-input transcriptional profiling. First we use a series of unbiased approaches to identify functional differences between auto-reactive T cells derived from MS or healthy donors.
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DISSECTION OF HOST-VIRUS INTERACTIONS IN THE HUMAN CENTRAL NERVOUS SYSTEM
… approach, we performed high temporal resolution transcriptional profiling of human cortical neurons upon infection with herpesviruses. This allowed us to dissect neuronal responses from 30 minutes to 48 hours post infection (hpi) to HSV-1 and VZV infections, identifying a delayed antiviral …
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The Role of DNA Methylation in Addiction and Depression
… cocaine-induced DNA methylation at gene targets. Transcriptional profiling experiments in which I virally overexpressed Dnmt3a or pharmacologically blocked DNA methylation identified an important role of DNA methylation in regulating the mRNA expression of a number of immediate early genes—several …
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Correlates of risk of TB disease in infants with differential response to BCG vaccination
… different between cases and controls. However, transcriptional profiling of PBMC revealed two clusters of infants and interestingly, the gene expression profiles from cases and controls in the two clusters were in opposite directions. Based on this, we hypothesised that analysing the two …
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Self-renewal pattern-associated genes and their role in adult stem cell functions
… and isolation of rare ASCs. Previously, reported transcriptional profiling studies for defining molecular features of ASCs were compromised by the use of impure ASC preparations. Thesis for this research was that the study of asymmetric self-renewal, a defining property of ASCs, might provide key …
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