Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"transcriptional network"”.
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THE NRF-1/GABP/BRCA1 Transcriptional Network in Mammary Epithelial Differentiation
… we determined that BRCA1 is at the end of a transcriptional network comprised of NRF-1 and GABP, a transcription factor comprised of two distinct subunits GABPalpha and GABPbeta. Decreased BRCA1 transcription in SK-BR-3 cells was found to be caused by aberrant activation of the GABPbeta …
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In Vivo Genome-Wide Analyses of the Drosophila p53 Transcriptional Network
… postmitotic p53 programs are distinct from networks described in developing cells. I found that the canonical p53 apoptotic program is unresponsive in Drosophila heads, establishing this system as an ideal in vivo model to study alternate functions of p53. To determine how p53 differential …
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Inferring Transcriptional and Post-Transcriptional Network Structure by Exploiting Natural Sequence Variation
… variation at the level of gene regulatory networks rather than individual genes. This thesis consists of four parts, each of which outlines a different strategy for integrating genome-wide expression data and genotype data in order to identify transcriptional and post-transcriptional …
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A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
… ccRCC. Thus, the identification of cellular networks on which ccRCC cells are highly dependent would facilitate the development of better diagnostic and/or therapeutic approaches for ccRCC. Super enhancers have been reported to drive the expression of critical transcription regulators in …
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Practical Approaches to Biological Network Discovery
… biology, which is to identify the structure of a transcriptional network from high-throughput experimental data. Understanding of the connectivity of a transcriptional network is an important piece of the puzzle, which relates the genotype of an organism to its phenotypes. An overwhelming number …
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The genetic interactions of PKHD1 and ATMIN in autosomal recessive polycystic kidney disease (ARPKD)
… collecting duct (mIMCD3) cells identified new transcriptional targets of Atmin, which did not include Pkhd1 but included genes associated with cystic kidneys in animal models (Camk2g and G6pc). NGS in Atmin and Pkhd1 KDs identified a common transcriptional network between the two genes. Gene …
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Genetic and Molecular Analysis of Islet-and Liver-Enriched Transcription Factors in Metabolism and Development
… are functionally related and form an integrated transcriptional network that plays an essential role in development and in different metabolic pathways.</p>
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SPATIOTEMPORAL CONTROL OF THE SALT STRESS INDUCED TRANSCRIPTIONAL RESPONSE IN ARABIDOPSIS
… spatiotemporally under salt stress and how transcriptional regulation occurs. Firstly, I did an analysis on a previously generated spatiotemporal transcriptional map of salt stress in Arabidopsis roots, covering 4 core cell types and 6 time points for salt treatment. Based on this …
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Signal Transduction and Transcriptional Regulation Pathways Essential for Azole Resistance in Candida albicans
… together, our results demonstrate that the UPC2 transcriptional network is universally essential for azole resistance in C. albicans and represents an attractive target for enhancing azole antifungal activity. Fungal survival in the presence of the azoles is permitted by specific signal …
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Recording Transcription Factor Binding During Development
… experiment. I applied the method to map the transcriptional network of 28 multiplexed transcription factors during the yeast developmental process of pseudohyphal growth. The method was next re-engineered to use a different transposon, piggyBac, making the technique applicable to mammalian …
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Communication between layers in biological transcriptional networks
… and regulate one another in the underlying network of the cell. Much of the current work in modeling yeast transcriptional networks focuses on the regulatory effect of a class of proteins known as transcription factors (TF). However, other sets of factors also influence transcription, …
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ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
… essential part of our adaptive immune system. A network of transcription factors together with external signals facilitate the gradual developmental progression from progenitor cells towards the B-cell fate. Several key factors participating in this network have been identified. Among these are …
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Phenomenological models in biological physics : cell growth and pluripotency maintenance
… embryonic stem cell's pluripotency by a complex transcriptional network.
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Roles of Neurogenin and Geminin in Vertebrate Neurogensis
… their target genes. Here, we identified direct transcriptional targets of the bHLH transcription factor Neurogenin. We found that Neurogenin regulates neurogenesis by activating transcription factors, cell signaling components, and genes regulating cytoskeleton rearrangement and cell migration. …
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The Arabidopsis thaliana Heat Shock Transcription Factor A1b Transcriptional Regulatory Network
… which include the initiation of complex transcriptional regulatory circuits. The heat shock transcription factors (HSFs) have been shown to be central regulators of plant responses to abiotic and biotic stress conditions. However, the extremely high multiplicity in plant HSF families …
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Transcriptional Profiling of Early Cardiac Development
… heart. The second study focused on defining the transcriptional network of a key cardiac regulator, Nkx2.5. I identified transcripts misexpressed during the early development of Nkx2.5 null embryos, including the Nkx2.5 transcriptional targets ETSrelated transcription factor 71 and vascular cell …
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Prospective Isolation And Characterization Of Mononucleated And Binucleated Cardiomyocytes
… associated cell sorting (FACS) and profiled the transcriptional differences between MoNuc and BiNuc cardiomyocytes at three different timepoints spanning cardiomyocyte maturation. Transcriptome analysis revealed that during the neonatal period, binucleation is associated with the termination of a …
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Genome-wide expression and location profiling in Saccharomyces cerevisiae : experimental and graphical analysis
… functions for these regulators. Understanding a transcriptional network such as these will be useful in constructing a cellular regulatory network map. The use of microarray technology has created new challenges in data analysis for biologists. Visual displays can greatly facilitate the analysis …
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Relating topology and dynamics in cell signaling networks
… the complex, interlocked feedback loops of transcriptionally regulated signaling pathways, and the multiple mechanisms of connection that link distinct pathways together into a full cell decision process. In this thesis, we address challenges at each level. We develop new computational …
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The Role of the TBX5-driven Regulatory Network in the Manifestation and Sustainability of Atrial Fibrillation
… development during embryogenesis. The multi-tier transcriptional network driven by TBX5 and modulated by PITX2 links 7 AF loci. This regulates many gene expressions, which play a crucial role in AF susceptibility. The exact mechanism underlying AF due to the genetic impairment and mutations is not …
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