Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"transcriptional deregulation"”.
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Identification of DNA Copy Number-Dependent Transcriptional Deregulation inHepatocellular Carcinoma (HCC)
… genomic copy number variation and concomitant transcriptional deregulation, is posited to provide a promising strategy to identify driver targets. Here, the integrative analysis of the DNA copy numbers and gene expression profiles of hepatocellular carcinoma (HCC) was performed. By comparing …
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Mechanisms of human papillomavirus and host gene transcriptional deregulation in cervical carcinogenesis
… modification (PTM) hallmarks of transcriptionally active chromatin and reduced levels of repressive hallmarks. There was greater abundance of the active/elongating form of the RNA polymerase-II enzyme (RNAPII-Ser2P), together with CDK9, the component of positive transcription …
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Molecular analysis of the role of E2F proteins in the pRB pathway
… of these mutations may be mediated at the transcriptional level by E2F. E2F is also regulated by cell cycle-dependent interactions with the pRB-related proteins p107 and p130. Unlike pRB, mutations in p107 or p130 are not associated with cancer. The different properties of the pRB family …
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Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
… Acetylation of histone is associated with transcriptional activation while deacetylation is linked to transcriptional repression. Moreover, histone deacetylase inhibitors induce growth arrest, differentiation and apoptosis of cancer cells and therefore appear to be promising anti-tumor …
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UNRAVELLING MECHANISMSOF SCHWANN CELLS IN VESTIBULAR SCHWANNOMA AND THEIR IMPACT ON HEARING LOSS.
… RNA-seq analysis revealed EMF-dependent transcriptional deregulation affecting pathways associated with migration, oncogenic signalling, and hearing loss-related genes. Because of the limited availability of human VN and VS tissues, a physiologically relevant alternative model was …
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Deciphering pre-leukaemic dysregulation caused by mutant C/EBPα at the level of the single cell
… to explore pre-leukaemic dysregulation of transcriptional networks because it is a significant player in normal myelopoiesis, it interacts with other transcription factors (TFs) in lineage specification, and the CEBPA gene has been identified as an early mutation in acute myeloid leukaemia …
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Investigation of transcriptional regulation by C. elegans SET-2/SETD1 H3K4 methyltransferase through single-nucleus profiling
Diverse epigenetic regulation modulates the transcriptional output of a cell. Among these, trimethylation of lysine 4 on histone H3 (H3K4me3), catalyzed by the SETD1 family of histone methyltransferases, is a well-established hallmark of active promoters in eukaryotes. Although loss of SETD1 …
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GENOMIC AND EPIGENETIC APPROACHES IN THE CLINICAL AND PROGNOSTIC STRATIFICATION OF CHRONIC LYMPHOCYTIC LEUKEMIA
… profile (GEP) analysis revealed specific transcriptional patterns and altered molecular pathways associated with 17p aberrations. SNP-array technology and gene expression profiling data were also applied to investigate the 13q14 deletion occurring in a panel of 100 CLLs representative of …