Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 134 for “"transcriptional control"”.
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Post-transcriptional control of gene expression
… we explore several aspects of gene expression control by analyzing data from biological experiments. Most of the work following uses a common mathematical model framework based on Markov chain models to test hypotheses, predict system dynamics or elucidate network topology. Our work lies in the …
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MYC-DEPENDENT TRANSCRIPTIONAL CONTROL IN HUMAN LYMPHOMA
… showed that MYC loss elicited rapid changes in transcriptional activity at several hundred loci in each lymphoma cell line, with a conserved core of 187 MYC-dependent genes showing immediate and persistent down-regulation (from 1 to 8 hours after treatment) followed by consistent reductions in …
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Interphase phosphorylation of H1.4 in transcriptional control
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-12-01
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TRANSCRIPTIONAL CONTROL OF Ca2+ SIGNALING IN T CELLS
… a key regulator of T cell activation through its transcriptional control of genes in multiple process including cytokine production, proliferation and differentiation(Rao, Luo, & Hogan, 1997). Recently it was shown that Stromal Interaction Molecule 1 (STIM1) inhibits plasma membrane Ca2+/ATPase 4 …
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G-Quadruplexes As Molecular Targets For Transcriptional Control
… G4s to date, and their stabilization cultivates transcriptional silencing. Downregulation of MYC reduces cell growth and alters cell energetics; it is promising for a variety of cancer types, including lymphomas and leukemias. VEGF downregulation modulates angiogenesis, therapeutically benefiting …
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Transcriptional control of somatosensory neuron diversification in Drosophila
… targeting. Together these results identify a transcriptional program that coordinately specifies proprioceptive dendrite morphology and sensory axon targeting to modality-specific domains of the CNS. Using a candidate based approached I have identified three molecular regulators of …
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Mechanisms of Transcriptional Control by the Mediator Complex Subunit Cdk8
Transcription is a tightly regulated process wherein RNA polymerases (RNAPs) use DNA as a template to synthesize RNA. In eukaryotes, RNAPII transcribes all protein-coding and many types of non-protein-coding genes. The multi-subunit Mediator complex functions in RNAPII transcription regulation by …
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The transcriptional control of virulence gene expression in Helicobacter pylori
… in detail in the present thesis regarding their transcriptional regulation. As an essential factor for the early phase of infection, including the colonisation of the gastric mucosa, the flagella are analysed; the chaperones including the putative adhesion factors GroEL and DnaK are investigated …
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Transcriptional Control during Quorum Sensing by LuxR and LuxR Homologues
… and I206) that appear to play a role in positive control of transcription initiation. Additional mutagenesis of residues 180-189 has been undertaken via a three-primer or four-primer PCR-based method in this study. Variants of LuxR were screened for their ability to activate luciferase production …
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Communal Cell Death and P53 Mediated Transcriptional Control in Drosophila Melanogaster
The file named "LinkNichole.pdf" is the primary dissertation file. Supplemental QuickTime video files are also available ("movieS1-LinkNichole.mov", "movieS2-LinkNichole.mov", "movieS3-LinkNichole.mov").
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Sox2-Dependent Transcriptional Control of Airway Differentiation In The Mouse Lung
… of different cell types need to be precisely controlled. The conducting airways contain four lung cell types: club cells, ciliated cells, basal cells, and neuroendocrine cells.SOX2 is a well-known conducting airway marker. SOX2 is a transcription factor that is known to be important in …
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Transcriptional and Post-transcriptional Control of Nhlh2 with Differing Energy Status
… study demonstrated that Nhlh2 could be regulated transcriptionally by both NFκB and Stat3 transcription factors and post-transcripitionally by the 3'UTR SNP that converts adenosine to guanine.
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Transcriptional control of the mitotic regulator string, in Drosophila / by Briony Patterson.
This thesis demonstrates that string (a homologue of the mitotic initiator cdc 25 from Schizosaccharomyces pombe) is a downstream target of the patterning genes, making a direct connection between patterning information and morphogenesis, which suggests that mitotic timing forms an independent and …
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Characterization and Transcriptional Control of the Rabbit Cytochrome P450pbii Genes (Evolution, Isozymes)
The phenobarbital (PB)-inducible cytochrome P-450(P-450) family is tentatively divided into the PBI (including rat P-450s b and e, and rabbit P-450 (form 2)), and PBII (including rabbit P-450s PBc1, PBc2, PBc3 (form 3b), PBc4 and (form 1)) subfamilies that are 55-60% homologous in their protein …
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A synthetic biology platform for malaria parasites based on orthogonal transcriptional control
… In light of this, we have created systems that control gene expression in the malaria parasite Plasmodium falciparum using bacterial repressor proteins. These are the first tools to reliably control malaria parasite transcription and offer the most robust method of conditional gene expression in …
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Multiplexed transcriptional control strategies for biosynthesis from mixed substrates in Escherichia coli
… for biosynthesis. This thesis aims to develop transcriptional control strategies that sense and respond to changing feedstock conditions for biosynthesis and demonstrate the ability to produce a product of interest from mixed substrate feeds. We constructed a galacturonate biosensor with the …
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Footprint Analysis of the Transcriptional Control of Glycogen Phosphorylase 2 in Dictyostelium Discoideum
… of this organism, implying a dependable control mechanism responsible for its developmentally regulated expression. I present in this thesis the identification of several putative cis-acting elements of gp-2 as revealed through footprint analysis. Due to the extreme AT-bias characteristic …
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Development of an inducible transcriptional control system in plasmodium falciparum with applications to targeted genome editing
… In particular, the ability to inducibly control gene expression and edit the genome in a site-specific manner present significant challenges. In addition, the building of genetic constructs poses challenges due to the required vector size and the high A+T richness of the P. falciparum …
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