Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"transcriptional bursting"”.
-
Transcriptional bursting in eukaryotic gene regulation : molecular basis and functional consequences
… mechanistic details and functional responses of transcriptional bursting in budding yeast. At the molecular level, we show that gene-specific activators can control both burst size and burst frequency by differentially utilizing kinetically distinct promoter elements. We also recognize the …
-
Highly Constrained Kinetic Models for Quantitative Single-Cell Gene Expression Analysis
… RNA polymerase II in eukaryotes. Variability in transcriptional outcomes arises from both regulatory mechanisms and stochastic events, making it essential to understand transcription dynamics to better grasp heterogeneity within gene regulatory networks. This dissertation investigates …
-
Nuclear speckle dynamics and function of speckle association in gene expression
… increased mobility of nuclear speckles after transcriptional inhibition, including long-range directed motion of one speckle towards another speckle, terminated by speckle fusion, over distances up to 4 µm and with velocities between 0.2-1.5 µm/min. Frequently, 3 or even 4 speckles follow very …
-
Characterizing cell-cycle as a global regulator of stochastic transcription and noisy gene expression in S. cerevisiae
… production and degradation to infer underlying transcriptional dynamics. Rather than transcriptional bursting, we find that noise is driven by large differences in transcriptional activity between the G1 and S/G2/M stage of the cell cycle. Furthermore, we quantitatively characterize these …
-
Stochastic Modeling of Gene Expression and Post-transcriptional Regulation
Stochasticity is a ubiquitous feature of cellular processes such as gene expression that can give rise to phenotypic differences for genetically identical cells. Understanding how the underlying biochemical reactions give rise to variations in mRNA/protein levels is thus of fundamental importance …
-
Employing High Probability Gene Choice Elements to Understand Singular Odorant Receptor Expression
… signal in the nucleus, indicative of active transcriptional bursting. Surprisingly, although cytoplasmic RNA signal from both transgenic loci were simultaneously detected in the same OSN, more often, active transcriptional bursts in the nucleus only showed signal from one of the two …
-
Mechanistic modeling and systems analysis across biological scales, from single cells and regulatory networks to microbial communities
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms