Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"transcriptional analysis"”.
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Transcriptional Analysis of Reciprocal Tumor-Microenvironment Interactions in Glioblastoma
<p>In the last twenty years both computational biology and cancer biology have made great strides and in the last 5 years the merger of the two has helped to revolutionize our knowledge of personalized targeted therapy and the diversity of cancer. In cancer, cell-to-cell interactions between tumor …
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Phenotypic and transcriptional analysis of secondary metabolites production in Pseudomonas corrugata CFBP5454
I prodotti naturali sono oggetto di grande interesse come alternativa sostenibile per la gestione delle malattie delle piante. In questo studio è stato valutato, mediante saggi fenotipici, analisi del genoma e studi di trascrizione, il potenziale ed effettivo arsenale di metaboliti secondari …
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Aromatic hydrocarbon metabolism by Rhodococcus sp. I24 : computational, biochemical and transcriptional analysis
… technology. Genes were selected for microarray analysis based on functional annotation assignments made by the Consensus Annotation by Phylogeny Anchored Sequence Alignment (CAPASA) program, a high throughput system for automated functional annotation assignment of DNA sequence similarity search …
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Total Genomic Transcriptional Analysis of the Fatty Acid Degradation Regulon of Escherichia Coli
The second ORF, b2323 is the fabB gene which produces beta-ketoacyl-ACP synthase I. This is one of two long chain specific condensing enzymes in E. coli and is required for unsaturated fatty acid biosynthesis. The other enzyme necessary for producing unsaturated fatty acids is …
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Global transcriptional analysis of an Escherichia coli recombinant protein process during hypoxia and hyperoxia
… production were observed through expression analysis of induced, uninduced, and Empty-Vector cultures. As expected, recombinant α₁AT production led to increased expression of heat-shock genes, including proteases and chaperones that are known to be involved in α₁AT degradation. Based on …
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Transcriptional analysis of the healing response of wounded nerves treated with collagen and silicone tubes
This study examines the transcriptional differences between nerve wounds treated with silicone tubes and those treated with collagen nerve regeneration templates. The primary motivation for the study is to test the hypothesis that the discrepancy between the low-quality regenerate that forms in a …
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Physiological, Metabolic, and Transcriptional Analysis of Submergence Tolerance in Rice and Nitrogen Use Efficiency in Wheat
… our understanding of how plants coordinate transcriptional, hormonal, and metabolic responses to submergence. However, the contribution of SUB1A to recovery from sublethal submergence is still unknown. This study revealed SUB1A's additional role in the recovery phase: promotion of a rapid …
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The toxigenic element of Clostridium difficile strain 10463 and its transcriptional analysis in strains which differ in toxigenicity
… in length in three nontoxigenic strains. Transcriptional analyses were undertaken using probes to each of the five open reading frames in the toxigenic element. Transcripts were detected for four of the open reading frames which are contiguous and transcribed in the same direction. In …
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Transcriptional analysis of the role of CD8+ T lymphocytes in acute neural herpes simplex virus infection / David C. Tscharke.
… IFN-[gamma]. A non-directed method of mRNA analysis is applied to HSV infected ganglia with the specific aim of identifying transcripts that may be associated with CD8+ T cell activity in the nervous system.
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The Impact of Nitrite on Aerobic Growth of Paracoccus denitrificans PD1222
… (fhb; Pd1689) and its associated NsrR family, transcriptional regulator (Pd1690), were transcribed above a ≥2 fold expression filter (p ≤ 0.05) at 95% significance in qRT-PCR and a type II microarray transcriptional analysis at 12.5 mM nitrite in batch culture. Additionally, >25 fold expression …
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Biochemical and Functional Investigations into the Contribution of SOX17 Mutations to the Pathogenesis of Pulmonary Arterial Hypertension
… exhibited decreased proliferation rates and transcriptional analysis suggested this to be a result of decreased cyclin A (CCNA1) and cyclin B (CCNB1) expression and increased expression of p15 (CDKN2B), a cyclin-dependent kinase inhibitor. Additionally, siSOX17-transfected PAECs showed …
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DIABETES MELLITUS AND THE DYSREGULATION OF ANGIOGENESIS IN TUBERCULOSIS
… Mycobacterium tuberculosis, alongside transcriptional analysis using single-cell RNA sequencing. Infection conditions were optimized based on reactive oxygen species production and cell viability. Following stimulation, a multiplex Luminex assay revealed early induction of angiogenic …
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Investigating the Role of Hippo/Warts Signaling in Sarcomatoid Renal Cell Carcinoma
… as is seen in some human sRCCs. Bioinformatic analysis reveals an enrichment of serum response factor (Srf) targets amongst genes upregulated following Lats1/2 deletion. Ablating Srf in the Lats mutant background causes Lats;Srf mutant cells to undergo epithelial to mesenchymal transition but …
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Transcriptomics-Guided Biodiscovery of Peroxidases from Macroalgae
… catalytic motifs but high sequence diversity. Transcriptional analysis in Saccharina latissima under stress conditions indicated upregulation, particularly under oxidative stress, suggesting a role in stress response. In addition, a cytochrome c peroxidase from Bryopsis plumosa (BpCcP) was …
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T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation
… and defective Th17 lineage commitment. Transcriptional analysis of BCAP deficient CD4 T cells revealed that BCAP is critical for the expression of genes associated with pathogenic Th17 lineage cells. Mice specifically lacking BCAP in T cells have normal development of steady state Th17 …
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Mechanical Confinement and Heat as Drivers of Aneuploidy in Cancer
… nocodazole, a microtubule inhibitor, and transcriptional analysis identifies confinement-induced dysregulation of mitotic programs. These results introduce the concept of a mitotic memory, in which transient mechanical stress on mitotic cells leaves lasting genetic changes. In Chapter 3, I …
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Exploiting crosstalk between growth and immunity in plants : the role of the <i>Phytophthora infestans</i> effector AVR2 in potato late blight
… primary defence responses in the plant.<br/><br/>Transcriptional analysis of brassinosteroid-treated S. tuberosum is used to identify a set of marker genes for active BR signalling. Strikingly, AVR2 is shown to upregulate <br/>this pathway, and specifically upregulates the transcription factor …
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Applying animal modelling to understand rare novel neurodevelopmental disorders associated with intellectual disability
… and cognitive tests with morphometric brain analysis and genome-wide transcriptional analysis. I then used this approach to study KPTN-related syndrome, a novel developmental disorder that to date has not been characterised in mice, successfully recapitulating the main phenotypes described in …
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Identification of the role of the sal locus in streptococcus pyogenes virulence during host-pathogen interactions
… the regulation of salKR gene expression. Transcriptional analysis of the sal locus revealed that expression of the salKR genes are governed by two promoters, the salA promoter and the salKR promoter. SalR regulates its own promoter by binding directly to repression sites identified both …
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