Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"transcriptional activation domain"”.
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Characterization of a Putative Activation Domain in the Hulk Gene Family
… proteins encoded by these genes share conserved domain structures including a proline-rich region (PRR) in the carboxyl-terminus. Based on sequence analysis and the presence of a proline-rich domain, it has been suggested that the HULKs are putative transcription factors in which HUA2 is known to …
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Analysis of the interaction between the co-chaperone p23 and the aryl hydrocarbon receptor
… hydrocarbon receptor (AhR) carboxyl terminal transcriptional activation domain was cloned, purified in denatured conditions from bacteria, refolded via limited dialysis, and analyzed for proper refolding via co-immunoprecipitation with the known binding partner SRC-1. This AhR NΔ515 …
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Hsp70-Mediated Regulation of Hsf1 Transcriptional Activity In Saccharomyces Cerevisiae
… Ssa1. I found that the Ssa1 substrate binding domain recognizes Hsf1 at two distinct sites, one previously defined as the CE2 within the carboxyl-terminal transcriptional activation domain, and one within the amino-terminal activation domain. Disruption of the identified <em>in silico</em> …
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Highly efficient Cas9 mediated transcriptional programming and delivery via Adeno-Associated Virus
… protein and the direct fusion of a synthetic transcriptional activation domain (AD). However, the modest levels of gene activation achieved by first generation Cas9 activators limited their potential applications. We describe the development of a versatile, improved transcriptional regulator …
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The Design and Development of Artificial Zinc Finger Transcription Factors and Zinc Finger Nucleases to the hTERT Locus
… factors would advance our understanding of the transcriptional regulation of hTERT, and also potentially produce new strategies for addressing telomerase-associated disease. In this work, we describe the engineering of artificial zinc finger transcription factors (ZFTFs) and zinc finger …
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A functional analysis of the epigenetic regulator CTCF
… including insulation, imprinting, X chromosome inactivation, and both transcriptional activation and repression. Recent data has also suggested a prominent role for CTCF in mediating interactions between chromosomes and in the global organization of the nucleus. In this work, we initiated a …