Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 3310 for “"transcriptional"”.
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Transcriptional and Post-Transcriptional Regulation of Retroelements
… mechanisms in place to restrain retroelements. Transcriptional silencing of retroelements is mainly achieved by heterochromatinization and DNA methylation. Our lab has demonstrated that p53 can also transcriptionally repress retroelements, however, the mechanism by which p53 mediates repression …
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Transcriptional and post-transcriptional regulation in tissue regeneration and disease
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Albumin Transcriptional Regulation
… involved in maintaining the liver specific transcriptional profile of the rat and mouse serum albumin genes. Using DNA transfection and recombinant viral infection, the minimal rat promoter and mouse enhancer elements were identified, functionally dissected and shown independently to be …
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Transcriptional and Post-transcriptional Control of Nhlh2 with Differing Energy Status
… study demonstrated that Nhlh2 could be regulated transcriptionally by both NFκB and Stat3 transcription factors and post-transcripitionally by the 3'UTR SNP that converts adenosine to guanine.
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Transcriptional and Post-Transcriptional Regulation of Nodule-Specific Gene Expression in Soybean
… not been compared. In addition, the role of post-transcriptional gene regulation during nodule development has not been thoroughly explored. Bridging these knowledge gaps is crucial to develop genetic/biotechnological strategies to optimize nutrient acquisition and sustainable production of crops. …
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Inferring Transcriptional and Post-Transcriptional Network Structure by Exploiting Natural Sequence Variation
… data and genotype data in order to identify transcriptional and post-transcriptional regulatory mechanisms. The data for these analyses comes from segregating populations of Saccharomyces cerevisiae (baker’s yeast) as well as Caenorhabditis elegans (roundworm). The first study focused on …
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Regulating Campylobacter jejuni flagellar gene expression: transcriptional and post-transcriptional mechanisms of control
… on the flagellar sigma factor, sigma28, and post-transcriptionally regulated expression of predicted sigma54-dependent C. jejuni flagellar gene targets in an E. coli based GFP reporter system. However, microarray and phenotypic analysis showed no clear differences in gene expression between …
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Global transcriptional, post-transcriptional, and translational regulation during soybean seed and seedling development
… the NAC and YABBY transcription factors. Post-transcriptional regulation is another layer of gene regulation. In order to dissect miRNA guided gene regulation in soybean developing seeds, a transcriptome-wide experimental method called degradome sequencing was carried out to directly detect …
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Transcriptional Regulation Of Adipocyte Function
… of adipocytes. While adipocyte development and transcriptional processes are well studied in vitro, regulation of in vivo genes (such as leptin), the identity of the adipocyte progenitor cells and the development of the adipose organ have not been defined invivo. In this thesis, firstly KLF4 was …
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Transcriptional regulation of mosquito oogenesis
… Distinct differences exist between the transcriptional regulation of <i>Ae. triseriatus</i> and <i>Ae. aegypti</i> oogenesis. TOR and many other proteins with previously unknown function are transcriptionally regulated during apoptosis and autophagy in mosquito ovaries during …
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Post-transcriptional regulation of IgE
Immunglobuline werden von den B Lymphozyten des Immunsystems in zwei Formen exprimiert: als sekretorische Form oder als membranständige Form. Die sekretorische Form der Immunglobuline bildet den Effektorarm des humoralen Immunsystems. Als integrale Membranproteine auf B Lymphozyten sind sie …
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Transcriptional divergence during cichlid embryogenesis
… fertilization to the larval stage, reveals that transcriptional variation emerges early in development despite the highly similar developmental trajectories of the two species. These differences likely arise not only from variations in maternal contributions at the 2-cell stage but also from …
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Computational Analysis of Transcriptional Regulation
… organisation of eukaryotic genomes and the post-transcriptional control of RNA fates. Eukaryotic nuclear DNA is tightly packaged as chromatin that is further folded into higher order structures. The 3D folding of eukaryotic genome lends itself to the formation of interactions between otherwise …
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Biomolecular Condensates in Transcriptional Regulation
Transcriptional regulation of gene expression is fundamental in determining cell behavior, identity, and organism development. When dysregulated it can cause disease. Core to transcriptional regulation is the control of RNA polymerase II (RNAPII) activity. The combined activity of DNA regulatory …
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Genome organization in transcriptional regulation
Transcriptional regulation of gene expression plays critical roles in the control of cell identity, development, and disease. Genome organization contributes to transcriptional regulation in multiple ways. At a fundamental level, the genome is organized into distinct active and repressive chromatin …
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Analysis of transcriptional regulatory circuitry
… with the goal of improving understanding of transcriptional regulatory circuitry in yeast. These microarray technologies, expression analysis and location analysis (ChIP on CHIP), bring unique challenges for data analysis. I have adapted methods described previously and have developing new …
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Transcriptional regulation in Corynebacterium glutamicum
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Transcriptional regulation and genome structure
… will focus on the role of genome structure in transcriptional regulation. Two key questions in this area that I have attempted to address during my PhD are "how are enhancer-promoter interactions constrained so that enhancers do not operate nonspecifically?" and "are there proteins that …
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THE TRANSCRIPTIONAL PROGRAM OF GOLGI BIOGENESIS
… in response to high secretory demand. However, transcriptional contribution to Golgi biogenesis remains poorly understood because of the lack of a robust method to induce large-scale production of new Golgi units. In this study, we developed an enzyme-based approach to eliminate the Golgi …
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