Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"transcription regulation"”.
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Transcription regulation and candidate diagnostic markers of esophageal cancer
… study was to enhance our insights of putative transcriptional circuitry of EC genes, thereby potentially positively impacting our knowledge of therapeutic targets, providing indications as to more appropriate lines of treatment, and additionally allowing for the determination of putative …
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Transcription regulation of the class II alcohol dehydrogenase 7 (ADH7)
… this dissertation is focused on studying ADH7 regulation and the effects of variants on this regulation using cell systems that replicate endogenous ADH7 expression. We identified elements regulating ADH7 transcription and observed differences in the effects of variants on gene expression. …
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New mechanisms in transcription regulation and chromosome organization in Caulobacter crescentus
Bacteria use a variety of mechanisms to control transcription in response to environmental cues or growth conditions. Activation or repression of transcription is often carried out by proteins, called transcription factors, that interact with DNA or RNA polymerase (RNAP) or both, and can change the …
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Mechanism Of Transcription Regulation And Stability Of The Quorum Sensing Protein Trar
TraR is a transcription activator of the quorum sensing system in the plant pathogen Agrobacterium tumefaciens. This protein is composed of two domains: amino-terminal domain (NTD) which is responsible for binding the autoinducer OOHL and for dimerization and the carboxyl-terminal domain (CTD) …
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Transcription regulation in Plasmodium falciparum : functional characterisation of general transcription factor IIB
… stage-specific gene expression. In eukaryotes, regulation of RNA Polymerase II transcription initiation is one of the main mechanism of gene expression control. Past research has revealed the presence of crucial elements of RNA Polymerase II (RNAPII) transcription machinery in P. falciparum, …
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Dissecting The Roles of Human Smc Complexes In Transcription Regulation and Chromatin Organization
… of distal regulatory elements to control gene transcription, and therefore they have to forge highly complex chromatin loops to spatially bridge these regulatory elements and genes in the three-dimensional (3D) genome. However, the hierarchy of chromatin contacts and their underlying mechanisms …
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DISTINCT GENOME WIDE FUNCTIONS OF CHROMATIN REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION
… REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION MAJOR PROFESSOR: Dr. Blaine Bartholomew Chromatin remodelers are conserved from yeast to humans and are the gatekeepers of chromatin. They regulate transcription by occluding or exposing DNA regulatory elements globally. …
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Single cell RNA-seq analysis uncovers transcription regulation mechanisms in mouse germline cells
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Signaling Pathway Inhibitor Library Screening Reveals B-Catenin/TCF4 as a Novel Telomerase Regulator in Cancer cell lines
… the screen and was later found to inhibit TA via transcription regulation of hTERT (human TERT). Activation of the Wnt pathway either by Wnt ligand (Wnt-3a) or LiCl (activates Wnt signaling by inhibiting GSK-3?) treatment as well as overexpression of a constitutively active form of ?-catenin (?-N …
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A bioinformatic study of the 5' upstream region of the human gene
Understanding transcription regulation is a key issue in biology. There is much non-coding sequence upstream of the human gene, a small proportion of which is regulatory. The aim of this project is to gain a better understanding of organisation, structure and function of this region via large-scale …
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Spatiotemporal control of gene expression in Caenorhabditis elegans
Cell-type specific regulation of transcription drives the production of the myriad of different cells generated during development. Profiling genome-wide gene expression landscapes in different tissues has improved our understanding of the physiological and pathological processes taking place …
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On the Modeling of Signaling Networks with Petri Nets
… The Boolean interpretation and modeling of transcription regulation networks also lends itself easily to Petri net modeling. However, Petri net modeling of signal transduction networks has been largely lacking, with the exception of simple ad hoc applications to specific signaling pathways. …
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STUDY OF EPIGENETIC REGULATORS AND SIGNATURES OF AGING
… aging, but it remains unclear if perturbation of transcription machineries may affect longevity. NELF-mediated pausing of RNA polymerase II (RNAPII) constitutes an important step in transcription regulation. I found that halving NELF-A level in heterozygous mutants or via neuronal-specific …
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Molecular mechanisms of phenotypic plasticity: Explorations of DNA methylation and transcriptional regulation using the honey bee
… it is essential to understand mechanisms of transcriptional regulation related to alternative phenotypes. This thesis focuses on two important aspects of transcriptional regulation: DNA methylation and transcription regulation by a nuclear receptor, Ultraspiracle (USP). Chapter 2 presents …
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Exploring the Functional Interaction Between CaMK-II and p53
… CaMK-II has been reported to be involved with transcription regulation, cell motility, neuronal development, cell cycle regulation, and more recently early development of vertebrates (Easley et al., 2008; Rothschild et al., 2009; Francescatto et al., 2010). Through previous work in the lab …
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Stochastic Modeling of Gene Expression and Post-transcriptional Regulation
… processes are intrinsically stochastic, cellular regulation must be designed to control the`noise' in order to adapt and respond to changing environments. Another focus of this dissertation is to develop and analyze stochastic models of post-transcription regulation. The analytical solutions of …
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RNA Polymerase II control in the changing transcriptional landscape
… as well as producing many other RNA species. Regulation of gene expression is essential for the viability of any organism, and it is primarily achieved at the transcriptional level. Transcriptional control is essential as cells adapt to changing conditions, ranging from undergoing …
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CRISPR-based Transcriptional Activators for Dissecting Human Gene-Regulatory Mechanisms
… human CBP and GCN5 and tested their efficacy as transcriptional activators. For the optimization of the dCas9-toolbox, we showed that affinity-purification-mass spectrometry could be applied to identify the antagonistic gene for these dCas9-based tools in the cellular context, which enables us to …
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Identifying Diagnostic Biomarkers: Gene Expression Profiling Leptin in Dental Pulp Tissue
… NextSeq Illumina and was analyzed using the ERGO transcription tool DESeq2 (P<0.05) statistical method to determine differences in transcription and subsequent translation between groups. The count data was imported into R-package for analysis and sequence mapping to the appropriate gene. The …
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